Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal composition of sulbenicillin sodium for injection and preparation method thereof

A technology of sulbenicillin sodium and its composition, which is applied in the field of sulbenicillin sodium nanoparticle injection and its preparation, can solve problems such as complex preparation process, and achieve the effects of good resolubility, good stability, and excellent stability

Active Publication Date: 2011-07-13
FUAN PHARM (GRP) CO LTD +1
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its preparation process is too complicated, and a large amount of toxic, flammable and explosive organic solvents are used, which poses a great safety hazard

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition of sulbenicillin sodium for injection and preparation method thereof
  • Medicinal composition of sulbenicillin sodium for injection and preparation method thereof
  • Medicinal composition of sulbenicillin sodium for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The preparation of embodiment 1 sulbenicillin sodium nanoparticle injection

[0065] Prescription 100 bottles

[0066] Sulbenicillin Sodium 100g

[0067] Methyl cyanoacrylate 500g

[0068] Dextran 5g

[0069] Mannitol 500g

[0070] Preparation Process:

[0071] (1) Add 100 g of sulfbenicillin sodium and 5 g of dextran into 2 L of water for injection, stir to dissolve, and adjust the pH value to 1.0 to 2.0 with hydrochloric acid.

[0072] (2) Add 500 g of methyl cyanoacrylate to the above solution under stirring, stir at room temperature for 4 hours, add 500 g of mannitol, continue stirring until completely dissolved, and adjust the pH value to 5.0-7.0 with sodium hydroxide.

[0073] (3) The above solution is filtered with a 0.22um microporous membrane to obtain a solution of sulbenicillin sodium nanoparticles.

[0074] (4) Divide the above solution into sterilized vials, pre-freeze at -45°C to -55°C for 3 hours, freeze-dry with a freeze dryer, seal with a sterile ...

Embodiment 2

[0075] The preparation of embodiment 2 sulbenicillin sodium nanoparticle injection

[0076] Prescription 100 bottles

[0077] Sulbenicillin Sodium 100g

[0078] Propyl cyanoacrylate 500g

[0079] Dextran 5g

[0080] Glucose 500g

[0081] Preparation Process:

[0082] (1) Add 100 g of sulfbenicillin sodium and 5 g of dextran into 2 L of water for injection, stir to dissolve, and adjust the pH value to 2.0 to 3.0 with formic acid.

[0083] (2) Add 500 g of propyl cyanoacrylate to the above solution under stirring, and then stir at room temperature for 5 hours, then add 500 g of glucose, continue stirring until completely dissolved, and adjust the pH value to 5.0-7.0 with sodium bicarbonate.

[0084] (3) The above solution is filtered with a 0.22um microporous membrane to obtain a solution of sulbenicillin sodium nanoparticles.

[0085] (4) Divide the above solution into sterilized vials, pre-freeze at -45°C to -55°C for 3 hours, freeze-dry with a freeze dryer, seal with a ...

Embodiment 3

[0086] The preparation of embodiment 3 sulbenicillin sodium nanoparticle injection

[0087] Prescription 100 bottles

[0088] Sulbenicillin Sodium 100g

[0089] n-Butyl cyanoacrylate 500g

[0090] Poloxamer 5g

[0091] Mannitol 500g

[0092] Preparation Process:

[0093] (1) Add 100 g of sulfbenicillin sodium and 5 g of dextran into 2 L of water for injection, stir to dissolve, and adjust the pH value to 1.0 to 2.0 with hydrochloric acid.

[0094] (2) Add 500 g of n-butyl cyanoacrylate to the above solution under stirring, and then stir at room temperature for 5 hours, add 500 g of mannitol, continue stirring until completely dissolved, and adjust the pH value to 5.0-7.0 with sodium hydroxide .

[0095] (3) The above solution is filtered with a 0.22um microporous membrane to obtain a solution of sulbenicillin sodium nanoparticles.

[0096] (4) Divide the above solution into sterilized vials, pre-freeze at -45°C to -55°C for 3 hours, freeze-dry with a freeze dryer, seal ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a medicinal composition of sulbenicillin sodium, in particular sulbenicillin sodium nano particle injection. The sulbenicillin sodium nano particle injection consists of sulbenicillin sodium, a carrier material, a stabilizer and an excipient, wherein the effective mean particle size of nano particles is 10 to 200nm. The invention also discloses the preparation method of the injection. The preparation method comprises the following steps of: mixing the sulbenicillin sodium and the stabilizer in water for injection, regulating a pH value, adding the carrier material and the excipient to obtain solution of sulbenicillin sodium nano particles, and freeze-drying to obtain the nano particle injection. The sulbenicillin sodium nano particle injection has the advantages of high resolubility, high stability, high loading rate, high clinical experiment safety and the like, and the process is suitable for industrialized mass production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of sulbenicillin sodium for injection and a preparation method thereof, more specifically, to a sulbenicillin sodium nanoparticle injection and a preparation method thereof. Background technique [0002] Sulbenicillin Sodium, its chemical name is (2S,5R,6R)-3,3-Dimethyl-6-(2-phenyl-2-sulfoacetamido)-7-oxo-4-sulfur Hetero-1-azabicyclo【3.2.0】heptane-2-carboxylic acid disodium salt, molecular formula C 16 h 16 N 2 Na 2 o 7 S 2 , molecular weight 458.42, structural formula: [0003] [0004] Sulbenicillin is a broad-spectrum semi-synthetic penicillin antibiotic that exerts its bactericidal effect by inhibiting the synthesis of bacterial cell walls. This product also has antibacterial activity against hemolytic streptococcus, Streptococcus pneumoniae, and staphylococcus that does not produce penicillinase, and has certain effects on anaerobic bact...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/19A61K31/43A61P31/04
Inventor 黄涛夏荣华陈小勇李述平张稳稳
Owner FUAN PHARM (GRP) CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com