Compound elder composition for treating bone injury and preparation method and pharmaceutical application thereof

A technology of elderberry and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, bone diseases, etc., can solve problems such as difficult quality control, poor drug stability, and insignificant curative effect, and achieve rapid growth of callus, Easy to operate, enhance the effect of promoting blood circulation, removing blood stasis and dredging meridians

Active Publication Date: 2013-01-02
匡海学 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It not only brings great pain to the patient physically and mentally, but also creates a lot of pressure and burden on the family and society.
Now there are many medicines for treating bone injury diseases. Western medicines are often simple in composition and act on a certain aspect of anti-inflammation, analgesia or promotion of bone healing in bone injuries. Most of the traditional Chinese medicine preparations used in clinical practice have many flavors, insignificant curative effect, rough preparations, difficult quality control, poor drug stability, etc., so that they cannot be used in clinical practice for a long time. in a state of relative lack
Elderberry and Achyranthes bidentata both come from traditional Chinese medicine, and are mostly used in the treatment of bone injuries in clinical practice. The compatibility of the two can play a synergistic effect, and comprehensively improve various indications of bone injuries in multiple ways and links. The composition of the two active ingredients It has not been reported for the treatment of bone injuries

Method used

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  • Compound elder composition for treating bone injury and preparation method and pharmaceutical application thereof
  • Compound elder composition for treating bone injury and preparation method and pharmaceutical application thereof
  • Compound elder composition for treating bone injury and preparation method and pharmaceutical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Pharmacological Experimental Research

[0012] 1. Therapeutic effect of active ingredient compositions with different compatibility ratios on rat fracture models

[0013] Sample: composition 1 (active ingredient extract of elderberry and active ingredient extract of Achyranthes bidentata 2:1 (weight ratio)),

[0014] Composition 2 (active ingredient extract of elderberry and active ingredient extract of Achyranthes bidentata 3:1 (weight ratio)),

[0015] Composition 3 (active ingredient extract of elderberry and active ingredient extract of Achyranthes bidentata 4:1 (weight ratio)),

[0016] Composition 4 (active ingredient extract of elderberry and active ingredient extract of Achyranthes bidentata 5:1 (weight ratio)).

[0017] Control drug: Dieda Wan

[0018] Experimental animal: Wistar rat

[0019] Experimental method: Rats were anesthetized by intraperitoneal injection of urethane, the left lower limb was depilated with sodium sulfide, th...

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PUM

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Abstract

The invention relates to a compound elder composition and a preparation method and pharmaceutical application thereof. The composition can be used for treating diseases such as bone injury and the like. The preparation method of the Chinese medicinal composition comprises the following steps of: performing heating reflux extraction on the root and the skin of elder by using 95 percent ethanol to obtain ethanol extract, suspending in water, adsorbing by using AB-8 macroporous resin, eluting by using the water, 10 percent ethanol and the 95 percent ethanol respectively, concentrating 10 percentethanol eluent and drying to obtain active ingredient extract of the elder; decocting twotooth achyranthes root in the water to obtain extract, suspending in the water, adsorbing by using D101 macroporous resin, eluting by using the water, 50 percent ethanol and the 95 percent ethanol respectively, concentrating 50 percent ethanol eluent and drying to obtain active ingredient extract of the twotooth achyranthes root; and mixing the active ingredient extract of the elder and the active ingredient extract of the twotooth achyranthes root in a ratio to prepare capsules, tablets, granules, pills,oral liquid, injection or external preparations.

Description

technical field [0001] The invention relates to a composition, in particular to a traditional Chinese medicine composition for treating bone damage. The composition is composed of active ingredient extracts of elderberry and achyranthes bidentata, and can be used for treating bone damage. Background technique [0002] Bone injury is a common clinical disease, mainly including: fracture, osteoporosis, etc. Various forms of bone injury are clinically high incidence. At present, there are many clinical methods for treating bone injuries, most of which are surgery or external fixation, combined with drug therapy. The bone injury takes a long time to heal, the patient suffers a lot, and there are still many unsatisfactory parts in the treatment effect. Taking fractures as an example, the symptoms are: long course of treatment, great pain, large callus at the fracture site, malunion at the fracture site to varying degrees, late functional exercise, slow growth of callus, and some...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/35A61P19/08
Inventor 匡海学杨炳友王秋红韩华朱晓清
Owner 匡海学
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