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Medicament for treating gout and preparation method thereof

A technology of medicine and gout, which is applied in the field of gout medicine and its preparation, can solve the problems of serious side effects and toxic side effects, and achieve the effects of drug quality control, low toxicity, and lower serum uric acid

Inactive Publication Date: 2011-08-03
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the conventional treatment for gout and hyperuricemia is still dominated by Western medicine, usually using colchicine, non-steroidal anti-inflammatory drugs, benzbromarone, probenecid, allopurinol and other chemical drugs, these drugs The purpose of relieving or treating gout and hyperuricemia is achieved through different action links. Although the curative effect is not bad, more and more clinical observations have found that they all have certain toxic and side effects, especially for middle-aged and elderly people and those with poor liver and kidney function. Side effects were more severe in able-bodied patients

Method used

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  • Medicament for treating gout and preparation method thereof
  • Medicament for treating gout and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prescription Tutai tablets 100g Hedyotis diffusa 250g Plantain 150g Iron broom 200g Mulberry parasite 120g Liangmianzhen 200g Dextrin 50g Sucrose powder appropriate amount.

[0040] The above Liuwei and Liangmianzhen are extracted twice with 60% alcohol under reflux, the first time is 2 hours, the second time is 1.5 hours, the extracts are combined, filtered, ethanol is recovered, and the concentration is continued to an extract with a relative density of 1.25-1.30 ;Five flavors such as Liangmianzhen medicine dregs and Tutai tablets, add 20 times the amount of water to soak for 1 hour, decoct 3 times for 1.5 hours each time, combine the decoction, filter, and concentrate to a relative density of 1.09-1.12 (70°C) Add ethanol to make the alcohol content 50%, let it stand for 12 hours, filter, reclaim the ethanol from the filtrate, continue to concentrate to the clear paste with a relative density of 1.25~1.30 (50°C), add the above-mentioned Liangmianzhen extract, Sucrose ...

Embodiment 2

[0042] Prescription Tutai tablets 250g Hedyotis diffusa 200g Plantain 400g Iron broom 300g Mulberry parasite 180g Liangmianzhen 150g Dextrin 50g Sucrose powder appropriate amount.

[0043] Preparation method is the same as in Example 1.

Embodiment 3

[0045] Prescription Tutai tablets 380g Hedyotis diffusa 350g Plantain 800g Iron broom 100g Mulberry parasite 280g Liangmianzhen 100g Dextrin 50g Sucrose powder appropriate amount.

[0046] Preparation method is the same as in Example 1.

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Abstract

The invention discloses a medicament for treating gout and a preparation method thereof. The medicament is characterized by being prepared from the following raw materials in parts by weight: 100-400 parts of rhizoma heterosmilacis japonicae, 100-400 parts of oldenlandia, 100-600 parts of plantain herb, 100-300 parts of lespedeza juncea, 100-300 parts of mistletoe, 100-200 parts of radix zanthoxyli, 50-90 parts of dextrin and a proper amount of sucrose powder. The medicament for treating gout, which is disclosed by the invention, can obviously reduce the serum uric acid of a mouse with hyperuricemia and inhibit the paw edema of a rat, and has analgesic action and good anti-gout efficacy. A toxicity test proves that the medicament disclosed by the invention has very small toxicity and can be taken safely. The preparation process of a product is relatively simple, and the quality of the medicament can be controlled easily.

Description

technical field [0001] The invention belongs to a medicine for treating gout and a preparation method thereof. Background technique [0002] Due to economic development, changes in diet structure and prolongation of human life expectancy, the incidence of gout has increased day by day, and it has become a common disease among middle-aged and elderly people in the world today. Moreover, the existence of gout can also lead to the exacerbation of coronary heart disease, diabetes, hypertension, etc., which has constituted a potential threat to human health. Modern medicine still has no radical cure method to primary disease at present. [0003] Gout is a group of clinical syndromes characterized by long-term purine metabolism disorder, decreased uric acid excretion, and tissue damage caused by increased blood uric acid. Hyperuricemia is the most important biochemical feature of gout. At present, the conventional treatment for gout and hyperuricemia is still dominated by Wester...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61P19/06
Inventor 赖茂祥陈小刚
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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