Leech freeze-dried powder injection solution for injection and preparation method thereof
A technology for freeze-dried powder injection and water for injection, which is applied in freeze-dried delivery, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of short stabilization time, restricted use, etc. Avoid easily degradable effects
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[0018] Example 1
[0019] A freeze-dried powder injection of leech for injection, which preparation includes the following steps:
[0020] (1) Preparation of leech polypeptide powder:
[0021] Take 2.0 kg of dried leeches and grind them into powder. Place the powder in a container with a lid. Use 20 times the volume of 40% acetone to soak and extract 4 times at 0-4°C. Combine the extracts and recover the acetone. Press and concentrate to a relative density of 1.05. Add ethanol to the concentrated solution until the final concentration of ethanol is 60%, stir well, let stand overnight at 0-4°C, filter, discard the precipitate, concentrate the mother liquor at 40°C under reduced pressure to a relative density of 1.05, add ethanol again to make The final concentration of ethanol is 85%, stir well, stand overnight at 0-4°C, and filter. The precipitate is collected and dried in vacuum until the precipitate does not contain ethanol and water to obtain 100.5 grams of leech polypeptide po...
Example Embodiment
[0026] Example 2
[0027] A freeze-dried powder injection of leech for injection, which preparation includes the following steps:
[0028] (1) Preparation of leech polypeptide powder:
[0029] Take 2.3 kilograms of dried medicinal materials of Japanese medicinal hirudo and grind them into powder. Place the powder in a container with a lid. Use 30 times the volume of 50% ethanol to soak and extract 4 times at 20°C. Combine the extracts and concentrate at 40°C under reduced pressure The relative density is 1.08. Add ethanol to the concentrated solution until the final concentration of ethanol is 60%, stir well, let stand overnight at 20°C, filter, discard the precipitate, concentrate the mother liquor at 40°C under reduced pressure to a relative density of 1.08, add ethanol again to make the ethanol The final concentration is 85%, stir well, stand overnight at 20°C, and filter. The precipitate is collected and dried in vacuum until the precipitate does not contain ethanol and water,...
Example Embodiment
[0034] Example 3
[0035] A freeze-dried powder injection of leech for injection, which preparation includes the following steps:
[0036] (1) Preparation of leech polypeptide powder:
[0037] Take 2.2 kg of dried medicinal materials of willow leaf leeches, grind into powder, place the powder in a covered container, use 40 times the volume of 30% acetone, leak and extract at 20°C, combine the extracts, and concentrate under reduced pressure at 40°C to a relative density For 1.10, add ethanol to the final concentration of ethanol to 60%, stir well, let stand overnight at 20°C, filter, discard the precipitate, concentrate the mother liquor at 40°C under reduced pressure to a relative density of 1.10, add ethanol again to make the ethanol final The concentration is 85%, stir well, stand overnight at 20°C, and filter. The precipitate is collected and dried in vacuum until the precipitate does not contain ethanol and water to obtain 105.5 g of leech polypeptide powder.
[0038] (2) Prepa...
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