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Oil-in-water type cinnamon oil nano emulsion oral liquid

An emulsion oral liquid, oil-in-water type technology, applied in the field of medicine, can solve the problems of low solubility, reduced curative effect of cinnamon oil, and low bioavailability, and achieve improved solubility, improved bioavailability, and good light transmittance Effect

Inactive Publication Date: 2011-08-31
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently clinically used preparations are mainly powders and pills, which can also be applied externally. However, due to the strong volatility of cinnamon oil, the solubility in water is very small, the bioavailability is low, and it is absorbed and eliminated quickly in the body, thereby reducing the The curative effect of cinnamon oil

Method used

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  • Oil-in-water type cinnamon oil nano emulsion oral liquid
  • Oil-in-water type cinnamon oil nano emulsion oral liquid
  • Oil-in-water type cinnamon oil nano emulsion oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Accurately weigh 3.6g of Tween-80, 0.6g of ethanol, 0.3g of 1,2-propanediol, 0.5g of isopropyl myristate, and 0.01g of cinnamon oil, and mix them thoroughly by manual stirring at room temperature of 25°C. Then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will become viscous. At this time, the system may appear liquid crystal or water-in-oil nanoemulsion. Continue Add dropwise and keep stirring, when the system suddenly becomes thinner, what is produced at this moment is a stable yellow transparent oil-in-water type Atractylodes atractylodes oil nanoemulsion oral liquid, and its total weight is 10g.

Embodiment 2

[0053] Embodiment 2 formula is as follows

[0054] RH-40 3.4g, ethanol 0.6g, glycerin 0.3g, olive oil 0.02g, cinnamon oil 0.35g, distilled water 5.33g.

Embodiment 3

[0055] Embodiment 3 formula is as follows

[0056] RH-40 3.2g, ethanol 0.4g, ethyl acetate 0.1g, cinnamon oil 0.3g, distilled water 6.0g.

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Abstract

The invention discloses oil-in-water type cinnamon oil nano emulsion oral liquid. The nano emulsion drop is 10 to 100nm in grain size and consists of the following raw materials in percentage by weight: 20 to 36 percent of surfactant, 2 to 16 percent of cosurfactant, 0.2 to 5 percent of oil, 0.1 to 8 percent of cinnamon oil and the balance of distilled water. The nano emulsion oral liquid has the advantages of improving the solubility of cinnamon oil, improving the medical stability, improving the bioavailability of cinnamon oil, prolonging the in vivo metabolism time of cinnamon oil, lowering the consumption of auxiliary materials, lowering production cost and enjoying a wide market prospect in medical field.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of cinnamon oil medicine, in particular to a transparent and stable oil-in-water cinnamon oil nanoemulsion oral liquid. Background technique [0002] Cinnamon oil is an aromatic oil obtained by distilling the bark, branches and leaves of lauraceae cinnamon. It is a yellow or yellow-brown clear liquid. There is a special smell of cinnamon, sweet and pungent. When it is exposed to the air or stored for a long time, its color will gradually become darker and its quality will become thicker. Slightly soluble in water, soluble in the same volume of alcohol and glacial acetic acid. The main component of the oil is cinnamaldehyde (Cinnamaldehyde), and contains a small amount of cinnamyl acetate (Cinnamylacetate), phenylpropyl acetate (Phenylpropylacetate). Cinnamon oil has a wide range of pharmacological activities, and has the pharmacological effects of sedation, cooling, low...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K9/107A61P1/08A61P1/14A61P11/04A61P15/00A61P15/10
Inventor 欧阳五庆宋冰李雅
Owner NORTHWEST A & F UNIV
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