Nano-analgesic agent and preparation method thereof

An analgesic and nanotechnology, applied in the field of nano analgesics and its preparation, can solve the problems of easy occurrence of gastrointestinal adverse reactions, restricting clinical application, etc., and achieve the effects of low cost, convenient administration and prolonging drug effect.

Inactive Publication Date: 2013-04-17
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gastrointestinal adverse reactions are prone to occur after taking it, which seriously restricts its clinical application

Method used

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  • Nano-analgesic agent and preparation method thereof
  • Nano-analgesic agent and preparation method thereof
  • Nano-analgesic agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Preparation of spinning stock solution: suspend 8.75g of ketoprofen in 100mL of methanol, and gradually add 35g of polyvinylpyrrolidone PVP K30 at 40°C and during rapid stirring (50rpm) to form a spinning stock solution;

[0033] (2) Preparation of ketoprofen / polyvinylpyrrolidone nanofiber membrane: Pour the above prepared spinning stock solution into the solution reservoir (5mL syringe), use the flattened No. 9 injection needle as the capillary for jetting fine flow, connect the high pressure For the positive electrode of the power supply, first use the aluminum foil fiber receiving plate with the glass slide as the negative electrode, accept the spun fiber for 10 minutes, use it for polarizing microscope observation, and then use the aluminum foil receiving plate to connect the negative electrode and accept the fiber; Electrospinning process Conditions: flow rate is 2mL h -1 , the distance between the receiving plate and the spinneret is 15cm, the voltage is 12kV,...

Embodiment 2

[0037] (1) Preparation of spinning stock solution: suspend 3 g of ketoprofen in 100 mL of ethanol, and gradually add 12 g of ethyl cellulose during heating to 48° C. and stirring to form a spinning stock solution;

[0038] (2) Preparation of Ketoprofen / Ethylcellulose Nanofiber Membrane: Pour the above prepared spinning stock solution into the solution reservoir (5mL syringe), use the flattened No. 9 injection needle as the capillary for jetting fine flow, connect The positive electrode of the high-voltage power supply is first connected to the negative electrode with an aluminum foil fiber receiving plate with a glass slide, and the spun fiber is accepted for 10 minutes for polarizing microscope observation, and then the aluminum foil receiving plate is used to connect the negative electrode to receive the fiber; Electrospinning Process conditions: flow rate is 1.5mL h -1 , the distance between the receiving plate and the spinneret is 10cm, the voltage is 15kV, the ambient tem...

Embodiment 3

[0041] (1) Preparation of spinning stock solution: 8.75g ketoprofen is suspended in 100mL methanol, and in the process of heating to 55° C. and stirring rapidly (50rpm), gradually add polyvinylpyrrolidone PVP K30 35g to form ketoprofen / Polyvinylpyrrolidone spinning solution;

[0042] Suspend 3 g of ketoprofen in 100 mL of ethanol, and gradually add 12 g of ethyl cellulose during heating at 45° C. and rapid stirring (50 rpm) to prepare a ketoprofen / ethyl cellulose spinning stock solution;

[0043] (2) Preparation of ketoprofen / polyvinylpyrrolidone / ethylcellulose nanofiber membrane: the first layer of electrospinning: pour the ketoprofen / polyvinylpyrrolidone spinning stock solution obtained above into No. 1 solution reservoir (5mL syringe ), the flattened No. 9 injection needle was used as the capillary for jetting fine flow, connected to the positive electrode of the high-voltage power supply, and the aluminum foil receiving plate was used to connect the negative electrode to ...

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Abstract

The invention relates to a nano-analgesic agent and a preparation method thereof. The nano-analgesic agent is a nano-fiber membrane composed of an organic substance and an inorganic substance, wherein the organic substance is a water-soluble or water-insoluble high polymer, and the inorganic substance is an analgesic substance. The preparation method of the nano-analgesic agent comprises the following steps: (1) preparing spinning solution containing the analgesic substance ketoprofen; and (2) carrying out electrostatic spinning on the spinning solution to obtain a fiber membrane, and then drying the fiber membrane to obtain the nano-analgesic agent. The nano-analgesic agent has the advantages of fast and long-lasting analgesic effect and is portable and convenient for administration in intestinal tract by a targeted positioning mode; and the preparation method is simple, and low in cost and has no special requirements on equipment, and the nano-analgesic agent can be produced in large scale.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and preparation thereof, in particular to a nano analgesic and a preparation method thereof. Background technique [0002] With the development of modern science and technology, especially materials science and pharmacy, the application of textile technology in pharmacy is developing in depth. Drug fiber is a new type of intermediate drug dosage form with fiber as a carrier under this background. Drug-loaded fibers can be processed into targeted drug delivery systems to reduce systemic drug doses and thereby alleviate the side effects of certain drugs. [0003] Ketoprofen is a white crystalline powder, almost insoluble in water, belonging to aryl alkanoic acid compounds, which has analgesic, anti-inflammatory and antipyretic effects; it is a powerful non-steroidal anti-inflammatory drug, but it is eliminated quickly in the body, It is insoluble in water and has certain gastrointestinal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/32A61K9/70A61K9/48A61K31/192A61P29/00
Inventor 朱利民黄丽娅余灯广
Owner DONGHUA UNIV
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