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Nano-analgesic agent and preparation method thereof

An analgesic and nanotechnology, applied in the field of nano-analgesics and their preparation, can solve the problems of restricting clinical application, prone to gastrointestinal adverse reactions, etc., and achieve the effects of low cost, convenient administration, and prolonged drug effect

Inactive Publication Date: 2011-09-14
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gastrointestinal adverse reactions are prone to occur after taking it, which seriously restricts its clinical application

Method used

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  • Nano-analgesic agent and preparation method thereof
  • Nano-analgesic agent and preparation method thereof
  • Nano-analgesic agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Preparation of spinning dope: Suspend 8.75 g of ketoprofen in 100 mL of methanol, and gradually add 35 g of polyvinylpyrrolidone PVP K30 at 40°C and rapid stirring (50 rpm) to prepare the spinning dope;

[0033] (2) Preparation of ketoprofen / polyvinylpyrrolidone nanofiber membrane: pour the prepared spinning stock solution into the solution reservoir (5mL syringe), use a flattened No. 9 injection needle as the capillary for the jet stream, and connect the high pressure For the positive electrode of the power supply, the aluminum foil fiber receiving plate with a glass slide is used as the negative electrode, and the fiber is spun for 10 minutes for observation by a polarizing microscope, and then the aluminum foil receiving plate is used to connect the negative electrode and receive the fiber; Electrospinning process Condition: Flow rate is 2mL·h -1 , The distance between the receiving plate and the spinneret is 15cm, the voltage is 12kV, the ambient temperature is (20±...

Embodiment 2

[0037] (1) Preparation of spinning dope: Suspend 3 g of ketoprofen in 100 mL of ethanol, and gradually add 12 g of ethyl cellulose during the process of heating to 48° C. and stirring to prepare the spinning dope;

[0038] (2) Preparation of ketoprofen / ethyl cellulose nanofiber membrane: pour the above-mentioned prepared spinning stock solution into the solution reservoir (5mL syringe), use a flattened 9-gauge injection needle as the capillary for the jet stream, and connect The positive electrode of the high-voltage power supply first uses the aluminum foil fiber receiving plate with a glass slide as the negative electrode, and receives the spinning fiber for 10 minutes for observation by the polarizing microscope, and then uses the aluminum foil receiving plate to connect the negative electrode and accept the fiber; Process conditions: flow rate is 1.5mL·h -1 , The distance between the receiving plate and the spinneret is 10cm, the voltage is 15kV, the ambient temperature is (20...

Embodiment 3

[0041] (1) Preparation of spinning stock solution: Suspend 8.75 g of ketoprofen in 100 mL of methanol, and gradually add 35 g of polyvinylpyrrolidone PVP K30 to prepare ketoprofen during heating to 55°C and rapid stirring (50 rpm). Polyvinylpyrrolidone spinning dope;

[0042] Suspend 3 g of ketoprofen in 100 mL of ethanol, and gradually add 12 g of ethyl cellulose during heating at 45°C and rapid stirring (50 rpm) to prepare the ketoprofen / ethyl cellulose spinning stock solution;

[0043] (2) Preparation of ketoprofen / polyvinylpyrrolidone / ethylcellulose nanofiber membrane: the first layer of electrospinning: pour the ketoprofen / polyvinylpyrrolidone spinning stock solution obtained above into solution reservoir No. 1 (5mL syringe In ), a flattened No. 9 injection needle is used as a capillary for jetting a trickle, connected to the positive electrode of a high-voltage power supply, and an aluminum foil receiving plate is used to connect the negative electrode and receive fibers; the...

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Abstract

The invention relates to a nano-analgesic agent and a preparation method thereof. The nano-analgesic agent is a nano-fiber membrane composed of an organic substance and an inorganic substance, wherein the organic substance is a water-soluble or water-insoluble high polymer, and the inorganic substance is an analgesic substance. The preparation method of the nano-analgesic agent comprises the following steps: (1) preparing spinning solution containing the analgesic substance ketoprofen; and (2) carrying out electrostatic spinning on the spinning solution to obtain a fiber membrane, and then drying the fiber membrane to obtain the nano-analgesic agent. The nano-analgesic agent has the advantages of fast and long-lasting analgesic effect and is portable and convenient for administration in intestinal tract by a targeted positioning mode; and the preparation method is simple, and low in cost and has no special requirements on equipment, and the nano-analgesic agent can be produced in large scale.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations and their preparation, and particularly relates to a nano analgesic and a preparation method thereof. Background technique [0002] With the development of modern technology, especially materials science and pharmacy, the application of textile technology in pharmacy is continuously developing in the direction of depth. Pharmaceutical fiber is a new type of intermediate drug formulation with fiber as a carrier that appears under this background. The drug-loaded fiber can be processed into a targeted drug delivery system to reduce the systemic drug dosage, thereby reducing the side effects of certain drugs. [0003] Ketoprofen is a white crystalline powder that is almost insoluble in water. It belongs to arylalkanoic acid compounds. It has analgesic, anti-inflammatory and antipyretic effects; it is a powerful non-steroidal anti-inflammatory drug, but it is quickly eliminated in the body. It is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K9/48A61K31/192A61K47/38A61K47/32A61P29/00
Inventor 朱利民黄丽娅余灯广
Owner DONGHUA UNIV
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