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A kind of preparation method of nanometer drug-loaded fiber membrane with temperature-sensitive drug release performance

A nano-drug-loading and temperature-sensitive technology, which is applied in the field of preparation of nano-drug-loaded fiber membranes, can solve the problems of low drug effectiveness, frequent medication, and toxic and side effects, and achieve convenient drug administration, easy portability, and simple preparation methods. Effect

Inactive Publication Date: 2017-06-30
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In clinical application, traditional medicines and preparations mostly have shortcomings such as low drug effectiveness, toxic and side effects, and frequent medication to maintain drug efficacy.

Method used

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  • A kind of preparation method of nanometer drug-loaded fiber membrane with temperature-sensitive drug release performance
  • A kind of preparation method of nanometer drug-loaded fiber membrane with temperature-sensitive drug release performance
  • A kind of preparation method of nanometer drug-loaded fiber membrane with temperature-sensitive drug release performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of spinning stock solution: Weigh 0.167gPNIPAAm and 0.333gEC respectively with an electronic analytical balance, dissolve the mixture of the two in 2 milliliters of absolute ethanol, then add 0.125gKET to the solution obtained, and bring the final gained solution to room temperature Under magnetic stirring for 24-48h, until completely dissolved (the mass ratio of PNIPAAm to EC in the solution is 1:2).

[0026] (2) The electrospinning solution obtained above is spun on an electrospinning device, using a No. 9 needle, wherein the voltage is 13 kV, the advancing speed of the syringe is 0.5 ml / hour, and the distance between the receiving plate and the spinneret is 15 cm. , the ambient temperature is (25±1)°C, and the ambient humidity is 57±3%. Receive it with aluminum foil, and after the electrospinning of the spinning liquid in the syringe is completed, remove the fiber membrane and dry it under vacuum at room temperature for 24 hours.

Embodiment 2

[0028] (1) Preparation of spinning stock solution: take by weighing 0.125gPNIPAAm and 0.375gEC respectively with an electronic analytical balance, dissolve the mixture of the two in 2 milliliters of absolute ethanol, then add 0.125gKET to the solution obtained, and put the final gained solution at room temperature Under magnetic stirring for 24-48h, until completely dissolved (the mass ratio of PNIPAAm to EC in the solution is 1:3).

[0029] (2) The electrospinning solution obtained above is spun on an electrospinning device, using a No. 9 needle, wherein the voltage is 13 kV, the advancing speed of the syringe is 0.5 ml / hour, and the distance between the receiving plate and the spinneret is 15 cm. , the ambient temperature is (25±1)°C, and the ambient humidity is 57±3%. Receive it with aluminum foil, and after the electrospinning of the spinning liquid in the syringe is completed, remove the fiber membrane and dry it under vacuum at room temperature for 24 hours.

Embodiment 3

[0031] (1) Preparation of spinning stock solution: Weigh 0.100gPNIPAAm and 0.400gEC respectively with an electronic analytical balance, dissolve the mixture of the two in 2 milliliters of absolute ethanol, then add 0.125gKET to the solution obtained, and place the final gained solution at room temperature Under magnetic stirring for 24-48h, until completely dissolved (the mass ratio of PNIPAAm to EC in the solution is 1:4).

[0032] (2) The electrospinning solution obtained above is spun on an electrospinning device, using a No. 9 needle, wherein the voltage is 13 kV, the advancing speed of the syringe is 0.5 ml / hour, and the distance between the receiving plate and the spinneret is 15 cm. , the ambient temperature is (25±1)°C, and the ambient humidity is 57±3%. Receive it with aluminum foil, and after the electrospinning of the spinning liquid in the syringe is completed, remove the fiber membrane and dry it under vacuum at room temperature for 24 hours.

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Abstract

A related preparation method for a nanometer drug-loaded fiber membrane with temperature-sensitive drug release performance comprises: (1) preparing a spinning solution containing a pain-easing medicine ketoprofen; and (2) preparing the nanometer fiber membrane from the above obtained spinning solution through an electrostatic spinning process, and performing vacuum drying to obtain a temperature-sensitive drug-loaded nanometer analgesic. The nanometer analgesic is capable of rapidly enduringly easing pain, is easy to carry and convenient for administration. The preparation method is simple, free of pollution, low in cost and free of special requirements on equipment, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of preparation of nanometer drug-loaded fiber membranes, in particular to a preparation method of nanometer drug-loaded fiber membranes with temperature-sensitive drug release performance. Background technique [0002] Nanofibrous membranes have the characteristics of large specific surface area and high porosity, and can be applied in the fields of filtration and separation, biosensing and tissue engineering. Electrospinning, as a simple, fast and general technique for preparing nanofibers, has attracted extensive attention from scholars at home and abroad in recent years. With the continuous development of electrospinning technology, the morphological structure of electrospun nanofibers has become increasingly diverse. Single nanofibers, highly oriented nanofibers, and nanofibers with special hierarchical structures or morphological characteristics have been reported. Moreover, the preparation of nanofibers by elec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/38A61K45/00A61K31/192D04H1/728D04H1/4334A61P29/00
Inventor 朱利民胡娟李赫宇杨卉卉
Owner DONGHUA UNIV
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