Preparation method of composite nanometer particulate anodyne

A technology of composite nanoparticles and analgesics, which is applied in the field of preparation of drug-loaded nanoparticles, can solve the problems of easy occurrence of gastrointestinal adverse reactions, restrict clinical application, etc. effective effect

Inactive Publication Date: 2013-01-16
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Gastrointestinal adverse reactions are prone to occur after taking it, which seriously restricts its clinical application

Method used

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  • Preparation method of composite nanometer particulate anodyne
  • Preparation method of composite nanometer particulate anodyne
  • Preparation method of composite nanometer particulate anodyne

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Suspend 6g of ketoprofen in 50mL of ethanol, and gradually add 6g of ethyl cellulose during heating and rapid stirring to form a suspension (the mass ratio of ketoprofen to ethyl cellulose is 1:1) .

[0026] Pour the above solution into the solution reservoir (5mL syringe), use a flattened No. 9 injection needle as the capillary for jetting thin stream, connect the positive electrode of the high-voltage power supply, first use the aluminum foil receiving plate with the glass slide as the negative electrode, accept Electrospray particles for 10 minutes for polarizing microscope observation, and then use an aluminum foil receiving plate to connect the negative electrode to receive electrospray particles.

[0027] EFI process conditions: flow rate is 1.5mL h -1 , the distance between the receiving plate and the electrospray is 10cm, the voltage is 15kV, the ambient temperature is 20°C, and the ambient humidity is 65%. After the solution in the syringe is electrosprayed, r...

Embodiment 2

[0030] Suspend 3g of ketoprofen in 50mL of ethanol, during heating and rapid stirring, gradually add 6g of ethyl cellulose to form a suspension (the mass ratio of ketoprofen to ethyl cellulose is 1:2) .

[0031] Pour the above solution into the solution reservoir (5mL syringe), use a flattened No. 9 injection needle as the capillary for jetting thin stream, connect the positive electrode of the high-voltage power supply, first use the aluminum foil receiving plate with the glass slide as the negative electrode, accept Electrospray particles for 10 minutes for polarizing microscope observation, and then use an aluminum foil receiving plate to connect the negative electrode to receive electrospray particles.

[0032] EFI process conditions: flow rate is 2.0mL h -1 , the distance between the receiving plate and the electrospray is 20cm, the voltage is 20kV, the ambient temperature is 19°C, and the ambient humidity is 70%. After the solution in the syringe is electrosprayed, remo...

Embodiment 3

[0035] 1.5g ketoprofen is suspended in 50mL ethanol, in heating and rapid stirring process, gradually add ethyl cellulose 6g, be made into suspending solution (the mass ratio of ketoprofen and ethyl cellulose is 1: 4 ).

[0036] Pour the above solution into the solution reservoir (5mL syringe), use a flattened No. 9 injection needle as the capillary for jetting thin stream, connect the positive electrode of the high-voltage power supply, first use the aluminum foil receiving plate with the glass slide as the negative electrode, accept Electrospray particles for 10 minutes for polarizing microscope observation, and then use an aluminum foil receiving plate to connect the negative electrode to receive electrospray particles.

[0037] EFI process conditions: flow rate is 1.8mL h -1 , the distance between the receiving plate and the electrospray is 15cm, the voltage is 16kV, the ambient temperature is 21°C, and the ambient humidity is 60%. After the electrospraying of the solutio...

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Abstract

The invention relates to a preparation method of a composite nanometer particulate anodyne, comprising the following steps of: (1) dissolving ketoprofen into ethanol with the mass volume ratio of ketoprofen to ethanol being 0.012-0.12g / 1ml, adding ethyl cellulose with the mass ratio of ethyl cellulose to ketoprofen being 1: 1-10, uniformly stirring to obtain a solution; (2) pouring the above solution into a solution reservoir, carrying out electronic injection, carrying out vacuum drying on a product at normal temperature to obtain the ketoprofen-ethyl cellulose composite nanometer particles.The composite nanometer particles prepared in the invention has functions of releasing medicaments and prolonging drug effects, and can be targeted and located in intestinal tracts; the preparation method provided by the invention has advantages of simple technology and low cost, and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of preparation of drug-loaded nanoparticles, in particular to a preparation method of a composite nanoparticle analgesic. Background technique [0002] With the development of material science and pharmacy, the use of new technology to prepare drug delivery system has attracted more and more attention. Drug-loaded nanoparticles is a new type of intermediate drug dosage form that uses nanoparticles as carriers under this background. Drug-loaded nanoparticles can be processed into targeted drug delivery systems to reduce systemic drug doses and thereby alleviate the side effects of certain drugs. [0003] Ketoprofen is a white crystalline powder, almost insoluble in water, and belongs to aryl alkanoic acid compounds. Has analgesic, anti-inflammatory and antipyretic effects. It is a powerful non-steroidal anti-inflammatory drug, but it is eliminated quickly in the body, insoluble in water, and has certain gastrointest...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16
Inventor 朱利民黄丽娅
Owner DONGHUA UNIV
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