Unlock instant, AI-driven research and patent intelligence for your innovation.

Correction method for UV-visible absorption spectrum of fiber in-situ medicine leaching degree/releasing degree tester

A technology of absorption spectrum and correction method, which is applied in the field of correction of ultraviolet-visible absorption spectrum, and can solve problems such as the inability to obtain ultraviolet-visible absorption spectrum and affecting the accuracy and reliability of analysis

Active Publication Date: 2012-11-21
上海富科思分析仪器有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this traditional technique can only obtain an uncorrected UV-visible absorption spectrum and the absorbance of several isolated feature points, and cannot obtain a corrected UV-visible spectrum that can truly represent the absorbance of the analyte at each wavelength. Absorption Spectrum
Moreover, due to errors in the process of reading feature point data and reference point data from the spectrogram, errors also exist in the corresponding correction process, and this error is further amplified in each step of correction calculation, so In the prior art, there are large errors in the process of correcting the ultraviolet-visible absorption spectrum by the dual-wavelength method, and this error is used in the analysis of substances that require accurate determination, such as drug analysis, especially the dissolution / release rate analysis of the drug dissolution process. , will greatly affect the accuracy and reliability of the corresponding analysis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Correction method for UV-visible absorption spectrum of fiber in-situ medicine leaching degree/releasing degree tester
  • Correction method for UV-visible absorption spectrum of fiber in-situ medicine leaching degree/releasing degree tester
  • Correction method for UV-visible absorption spectrum of fiber in-situ medicine leaching degree/releasing degree tester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] The method for correcting the ultraviolet-visible absorption spectrum of the optical fiber in-situ drug dissolution / release tester of the present invention comprises the following steps:

[0097] Step 1: The light source inputs light with a wavelength λ in the range of 200-1100 nm to the Y-shaped optical fiber;

[0098] Step 2: The Y-shaped optical fiber transmits the light with a wavelength λ range of 200 to 1100 nm into the blank solution in the dissolution apparatus through the probe at its end, then uses the probe to collect the optical signal, and passes the obtained optical signal through the Y Type optical fiber to transmit it to the detection module;

[0099] Step 3: The Y-shaped optical fiber inputs light with a wavelength λ range of 200 to 1100 nm into the solution to be tested in the dissolution apparatus through the probe at its end, and then uses the probe to collect the optical signal, and passes the obtained optical signal of the solution to be tested thr...

Embodiment 2

[0114] For Example 1, the acquisition process of the light intensity spectrum data of the blank solution and the solution to be tested was improved. The method for correcting the ultraviolet-visible absorption spectrum of the optical fiber in-situ drug dissolution / release tester of the present invention comprises the following steps:

[0115] Step 1: The light source inputs light with a wavelength λ in the range of 200-1100 nm to the Y-shaped optical fiber;

[0116] Step 2: The Y-shaped optical fiber transmits the light with a wavelength λ range of 200 to 1100 nm into the blank solution in the dissolution apparatus through the probe at its end, then uses the probe to collect the optical signal, and passes the obtained optical signal through the Y Type optical fiber to transmit it to the detection module;

[0117] Step 3: The Y-shaped optical fiber inputs light with a wavelength λ range of 200 to 1100 nm into the solution to be tested in the dissolution apparatus through the p...

Embodiment 3

[0139] On the basis of Embodiment 2, in this embodiment, an m×n photodiode array is used as the photodiode array module, where m=1˜8, n≧128. Each pixel point on the first axis of the photodiode array is marked as 0, 1...m in sequence. Each pixel point on the second axis of the photodiode array is marked as 0, 1, 2...n in sequence. The second axis of the photodiode array is parallel to the grating light splitting module. The photodiode array converts the light signals received by each diode into corresponding electrical signals, so as to obtain electrical signals of corresponding pixel points.

[0140] The method for correcting the ultraviolet-visible absorption spectrum of the optical fiber in-situ drug dissolution / release tester of the present invention comprises steps 1 to 9, wherein steps 1 to 3 are the same as in embodiment 1 and embodiment 2, specifically as follows:

[0141] Step 1: The light source inputs light with a wavelength λ in the range of 200-1100 nm to the Y-...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A correction method for a UV-visible absorption spectrum is disclosed in the invention. According to the method, the absorbency at any wavelength in the spectrum can be corrected, so as to obtain a complete and corrected UV-visible absorption spectrum with a minimum error during the correction process, thereby that the method is especially suitable for the field of substance analysis with a requirement of accurate measurement, in particular to the analysis of medicine leaching degree / releasing degree in the medicine leaching process. The correction method disclosed in the invention is suitable for a fiber in-situ medicine leaching degree / releasing degree tester, the interferences on the substances to be tested from other substances in the solution to be tested can be eliminated to obtaina real-time concentration curve of the substances to be tested, in particular to obtain a concentration-time curve of leaching degree / releasing degree of medicine solid dosage forms(such as tablets,capsules and the like).

Description

technical field [0001] The invention relates to a method for correcting an ultraviolet-visible absorption spectrum, in particular to a method for correcting the ultraviolet-visible absorption spectrum acquired by an optical fiber in-situ drug dissolution / release rate tester. Background technique [0002] The dual-wavelength method is a quantitative spectral analysis method based on the principle of ultraviolet-visible absorption spectroscopy. [0003] During the dissolution process of the solid drug preparation, the drug excipients are also dissolved along with the active ingredients of the drug. Therefore, the absorption spectrum obtained directly through spectrum acquisition during the measurement process includes the drug to be tested, the excipients and other substances. The absorption spectrum of the mixture. In process measurement, it is necessary to eliminate the interference of excipients or other substances, and the dual-wavelength method is a method for eliminatin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/33
Inventor 熊海江刘欢李翔胡旭张奇洲孔彬
Owner 上海富科思分析仪器有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com