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Transplanting material of fat granule tissues compounded with SVFs (Stromal Vascular Fractions) and PRFs (Platelet-Rich Fibrins) as well as preparation method and application thereof

A technology of fat particles and grafting materials, applied in medical science, prostheses, etc., can solve problems affecting soft tissue shaping or defect repair, adipose tissue is prone to liquefaction, and increases the cost of plastic surgery, so as to achieve no immune rejection and no need for in vitro Cultivate, obtain convenient effects

Active Publication Date: 2011-10-05
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

However, when the simple fat grafting material prepared by this method is used for soft tissue shaping and soft tissue defect repair, the transplanted fat tissue is prone to liquefaction, necrosis, fibrocystic degeneration, etc., resulting in 40% to 90% loss of the transplanted fat The absorption rate affects the soft tissue shaping or defect repair effect, and often requires multiple injections to meet the treatment requirements, which also brings inconvenience to patients and increases the cost of plastic surgery

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  • Transplanting material of fat granule tissues compounded with SVFs (Stromal Vascular Fractions) and PRFs (Platelet-Rich Fibrins) as well as preparation method and application thereof
  • Transplanting material of fat granule tissues compounded with SVFs (Stromal Vascular Fractions) and PRFs (Platelet-Rich Fibrins) as well as preparation method and application thereof
  • Transplanting material of fat granule tissues compounded with SVFs (Stromal Vascular Fractions) and PRFs (Platelet-Rich Fibrins) as well as preparation method and application thereof

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Embodiment Construction

[0027] The present invention will be described in more detail below in conjunction with the drawings and embodiments.

[0028] The preparation method of adipose granule tissue composite matrix vascular components and platelet-rich fibrin graft material includes the following steps:

[0029] The first step is to extract fat particles: using liposuction, suck 1ml of fat tissue from the patient’s abdomen or thigh, put it into a sterile Erlenmeyer flask, wash with saline, transfer it into a sterile centrifuge tube, centrifuge at 1000r / min for 2 minutes, Place in the refrigerator at 4℃ for later use;

[0030] The second step is to extract the platelet-rich fibrin membrane particles: Use a sterile syringe to draw 5ml of blood from the brachial vein of the same patient, add it to a sterile centrifuge tube, immediately centrifuge at 3000r / min for 10 minutes, and place it in a refrigerator at 4°C for 30 minutes. After waiting for the blood to coagulate, the blood coagulum is taken out, the b...

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Abstract

The invention belongs to the technical fields of tissue engineering and biological materials, in particular to a transplanting material of fat granule tissues compounded with SVFs (Stromal Vascular Fractions) and PRF (Platelet-Rich Fibrins) as well as a preparation method and application thereof. The transplanting material comprises fat granules, SVFs and PRF membrane granules. The preparation method comprises the following steps of: extracting fat granules from a patient by adopting liposuction, additionally extracting SVFs obtained by fat granule digestion from the same patient and extracting PRF membrane granules obtained by blood centrifuging from the same patient; mixing the SVFs with the PRF membrane granules; incubating at the temperature 37 DEG C for 10 minutes; and mixing the fatgranules, the SVFs and the PRF membrane granules to obtain the transplanting material of fat granule tissues compounded with the SVFs and the PRFs. The material can be applied to soft tissue molding and soft tissue defect repairing; by adopting the material, the absorption of transplanted fat tissues is effectively reduced, and the fat transplanting effect is improved.

Description

Technical field [0001] The invention belongs to the field of tissue engineering and biomaterials, and relates to soft tissue shaping and soft tissue defect repair technologies, in particular to a graft material of fat granule tissue composite SVF and PRF, and a preparation method and application thereof. Background technique [0002] At present, soft tissue shaping and soft tissue defect repair usually use autologous fat particle transplantation. The preparation method of autologous adipose tissue material is to use syringe suction to prepare injectable fat particles, without adding any other ingredients, and directly used for injection fat particle transplantation. However, the simple fat graft material prepared by this method is used for soft tissue shaping and soft tissue defect repair. The transplanted fat tissue is prone to liquefaction, necrosis, and fibrocystic degeneration, resulting in 40% to 90% of the fat grafted The absorption rate affects the soft tissue shaping or ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/38A61L27/36A61L27/54
Inventor 刘斌谭新颖贺建军葛旭刘彦普徐小方
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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