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Antibiotic compound containing piperacillin

A technology of piperacillin and antibiotics, applied in the field of antibiotic compound, can solve the problems of many particles, unstable solution, easy generation of particles in solution, etc.

Active Publication Date: 2011-10-12
ガンゾウ ヘメイ ファーマスーティカル カンパニー リミテッド
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] One problem with the preparation of Pisulide is that the solution is not very stable at room temperature, and unstable solutions tend to produce particles, especially after rethawing of the Pesulide solution that has been frozen or prepared as a lyophilized powder for reconstitution. solution, and the longer it is left, the more particles will be generated

Method used

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  • Antibiotic compound containing piperacillin
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  • Antibiotic compound containing piperacillin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0251] Recipe: piperacillin sodium 4g, sulbactam sodium 0.5g, gentamicin 80mg / 2mL injection.

[0252] Preparation method: Dissolve piperacillin sodium and sulbactam sodium in 100mL of water for injection, add gentamicin injection, immediately produce a large amount of white precipitate, ultrasonic for 15 minutes, the precipitate does not disappear.

Embodiment 2

[0254] 40 mg of piperacillin sodium and 5 mg of sulbactam sodium were dissolved in 2 mL of buffer solutions of various pH values ​​and strengths, and 20 μL of gentamicin 80 mg / 2 mL injection was added dropwise. Sonicate for 5 minutes to observe whether there is precipitation. The result is that no precipitation is formed when the pH value of the buffer is above 6, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table below.

[0255]

[0256] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK clear solution

Embodiment 3A

[0258] 40 mg of piperacillin sodium, 5 mg of sulbactam sodium and 0.01 mg of sodium EDTA were dissolved in 2 mL of various buffer solutions with different pH values ​​and strengths, and 20 μL of gentamicin 80 mg / 2 mL injection was added dropwise. Sonicate for 5 minutes to observe whether there is precipitation. The result is that no precipitation is formed when the pH value of the buffer is above 6, and a clear solution can be obtained. The type of buffer has little effect on the result. The results are shown in the table below.

[0259]

[0260] * The solution becomes slightly cloudy ** the solution becomes cloudy *** The solution is cloudy OK clear solution

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Abstract

The invention relates to an antibiotic compound containing piperacillin, sulbactam or clavulanic acid, and an ionic chelating agent capable of inhibiting particle generation. The compound can be further added with a buffer component as a steady system. The compound is characterized by being prepared into a steady solution preparation and prepared into a medicine for resisting microbial infection together with aminogylcoside antibiotics in the same container.

Description

Field of invention: [0001] The present invention relates to the antibiotic composition that is made up of piperacillin, sulbactam or clavulanic acid, ion chelating agent and / or buffer component, and the characteristic of this composition is that it can be made into stable solution preparation, and can be combined with aminoglycoside antibiotics Reconstituted into a stable solution in the same container as a drug for controlling microbial infections. technical background: [0002] Piperacillin inhibits the synthesis of bacterial cell walls by inhibiting the activity of D-alanyl-D-alanine transpeptidase (Peptidoglycan transpeptidase) in bacteria. Because mucopeptides are some sugar-containing polypeptides with a network structure, they are composed of N-acetylglucosamine (Glc-NAc) and N-acetylmuramic acid (Mur-NAc) alternately composed of linear glycan chain short peptides, these The high polymer needs to undergo a transpeptide cross-linking reaction under the catalysis of mu...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/43A61K31/424A61K9/08A61K9/14A61K9/19A61K47/12A61K47/18A61K47/04A61P31/04A61P31/00
Inventor 张和胜
Owner ガンゾウ ヘメイ ファーマスーティカル カンパニー リミテッド
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