Improvements relating to pharmaceutical compositions
A composition and mixture technology, which is applied in the direction of drug combination, bulk delivery, nanocapsules, etc., can solve the problems of not being able to prepare nano-dispersions, not teaching and providing nano-dispersions, etc.
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Embodiment 1
[0193] 0.10 g loratadine and 0.70 g hypromellose phthalate (HPMCP) were dissolved in 80 ml ethanol / acetone mixture (50% by volume); 0.10 g pluronic F127 and 0.10 g Mannitol was dissolved in 20 ml of distilled water. The aqueous solution was then added to the ethanol / acetone mixture and stirred using a magnetic bar to form a homogeneous solution. The solution was spray dried using a Buchi Mini B-290 spray dryer with an inlet temperature of 150°C and a liquid feed rate of 2.5 ml / min. A free-flowing white powder was obtained.
[0194] The dried powder samples were redispersed in phosphate buffer solution (pH=7.2) and nanoparticle size was measured using a Malvern Nano-S. A particle size measurement of 385±21 nm (at 5 mg / ml concentration) was obtained (after viscosity correction).
Embodiment 2
[0196] Dissolve 0.10 g loratadine and 0.80 g hypromellose phthalate (HPMCP) in 80 ml ethanol / acetone mixture (50% by volume); dissolve 0.10 g pluronic F127 in 10 ml distilled water . The aqueous solution was then added to the ethanol / acetone mixture and stirred using a magnetic bar to form a homogeneous solution. The mixture was spray dried using a Buchi Mini B-290 spray dryer with an inlet temperature of 150°C and a liquid feed rate of 2.5 ml / min. A free-flowing white powder was obtained.
[0197] The dried powder samples were redispersed in phosphate buffer solution (pH=7.2) and nanoparticle size was measured using a Malvern Nano-S. (uncorrected viscosity) gave a particle size measurement of 429±8 nm (at 5 mg / ml concentration).
Embodiment 3
[0198] Example 3 (Dissolution Test of Example 1):
[0199] 100 mg (equivalent to 10 mg of loratadine) of the spray-dried powder from Example 1 were dispersed in 900 ml of a dissolution medium (distilled water, pH=2.2 HCl solution or pH=7.2 phosphate buffer solution, respectively), Overhead paddle stirring at 50 rpm, (dissolution medium) temperature 37°C. Aliquots of each solution were withdrawn at 5 minutes, 10 minutes, 20 minutes, etc. using a pipette (1 ml Eppendorf pipette). The dispersion was then diluted with ethanol for detection of UV properties (1 ml of ethanol was added to 1 ml of the dispersion). The dissolution of Example 1 in different media is summarized in Table 1.
[0200] Table 1
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