Preparation method of mould cell catalyst for catalyzing synthetic reaction of cytarabine ocfosfate
A technology for catalyzing cytarabine ester and synthesis reaction, which is applied in the field of preparation of mold cell catalysts, can solve the problems of low product purity and low substrate utilization rate, achieve low nutritional requirements, simple and easy preparation, and mild reaction conditions Effect
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[0024] The regioselectivity of the catalyst obtained by the method of the present invention is determined by the regioselective acylation reaction of cytarabine and vinyl acetate, and the reaction condition is to add 0.05g of dry bacteria to the cytarabine esterification reaction system of 1mL Silk was used as a catalyst, the dosage of cytarabine was 5 mg, the reaction system was 75% (v / v) pyridine-n-hexane, the reaction temperature was 30°C, the shaking speed was 180 rpm, and the reaction was carried out under normal pressure for 24 hours. The reaction regioselectivity is characterized by: the yield of 3'-cytarabine ethyl ester / the total yield of cytarabine ester.
[0025] Example 2
Embodiment 2
[0027] Example 3
Embodiment 3
[0029] Example 4
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