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Chinese herbs paste for treating gastrointestinal dysfunction and preparation method thereof

A technology for gastrointestinal dysfunction and traditional Chinese medicine stickers, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of liver first-pass effect affecting drug efficacy, and achieve complete preservation of biological activity and drug delivery. Accurate dosage and improved clinical efficacy

Active Publication Date: 2012-10-03
NANJING ZHONGKE PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine is usually used orally to treat this disease, but the first-pass effect of the liver and the degree of absorption in the digestive tract often affect the efficacy of the drug

Method used

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  • Chinese herbs paste for treating gastrointestinal dysfunction and preparation method thereof
  • Chinese herbs paste for treating gastrointestinal dysfunction and preparation method thereof
  • Chinese herbs paste for treating gastrointestinal dysfunction and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] a) Atractylodes macrocephala medicinal material is pulverized into coarse powder;

[0058] b) The coarse powder of Atractylodes macrocephala is put into an extraction tank and subjected to supercritical extraction with carbon dioxide. Set the extraction pressure to 28MPa, the extraction temperature to 38°C, and extract for 80 minutes; collect the Atractylodes macrocephala extract from the separator.

[0059] c) Take the extract of Atractylodes Rhizoma Atractylodes Rhizoma Rhizoma Rhizoma Rhizoma Rhizome and add 5 times the weight of the extract of Atractylodes Rhizoma Rhizome, namely polyvinyl alcohol, glycerin, zinc oxide and peppermint oil (weight ratio is 2:2:3:0.5), and mix well to form a paste. 10 grams of paste is equivalent to 5.0 grams of crude drug.

[0060] d) coating the paste on the non-woven fabric, and covering the surface of the paste with a layer of protective film to obtain a traditional Chinese medicine external patch.

Embodiment 2

[0062] a) Atractylodes macrocephala medicinal material is pulverized into coarse powder;

[0063] b) The coarse powder of Atractylodes macrocephala is put into an extraction tank and subjected to supercritical extraction with carbon dioxide. Set the extraction pressure to 25MPa, the extraction temperature to 35°C, and extract for 90 minutes; collect the Atractylodes macrocephala extract from the separator.

[0064] c) Take the extract of Atractylodes Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome and add a matrix twice the weight of the extract, namely gelatin, carboxymethyl cellulose, glycerin, kaolin and dimethyl sulfoxide (weight ratio is 1:1:2:1:1), Mix evenly, prepare into medicinal paste, every 10 grams of paste is equivalent to 10.0g of crude drug;

[0065] d) Apply the paste on the polyethylene film, cover the surface of the paste with a protective film, cut into pieces, perform quality inspection, and pack the finished product. Obtain the ex...

Embodiment 3

[0067] a) Atractylodes macrocephala medicinal material is pulverized into coarse powder;

[0068] b) The coarse powder of Atractylodes macrocephala is put into an extraction tank and subjected to supercritical extraction with carbon dioxide. Set the extraction pressure to 20MPa, the extraction temperature to 37°C, and extract for 60 minutes; collect the Atractylodes macrocephala extract from the separator.

[0069] c) Take the extract of Atractylodes Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome and add a matrix 10 times the weight of the extract, namely sodium polyacrylate, glycerin, micronized silica gel and peppermint oil, in a weight ratio of 3:2.5:8:2. For the prepared medicinal ointment, every 10 grams of ointment is equivalent to 1.0 g of crude drug.

[0070] d) Apply the paste on the polyethylene film, cover the surface of the paste with a protective film, cut into pieces, perform quality inspection, and pack the finished product. Obtain the external use pa...

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Abstract

The invention discloses a Chinese herbs paste for treating gastrointestinal dysfunction and a preparation method thereof. The paste is prepared through the following steps of: crushing white atractylodes rhizome medicinal materials into coarse powder; supercritically extracting by adopting CO2, and then adding an obtained extractive to a matrix to prepare a medicine. The Chinese herbs paste disclosed by the invention has stable property and an obvious improvement action on the gastrointestinal dysfunction; in addition, the medicine has a pharmacological effect obviously superior to that of the traditional applied composite of a white atractylodes rhizome essential oil component and a white atractylodes rhizome water extraction component, a composite of the white atractylodes rhizome essential oil component and a white atractylodes rhizome ethanol extraction component and a single component extractive, and the advantages of high medical transdermal absorption rate, good air permeability, continuous medicine release, long effect, convenience for use and no skin allergy or clothes contamination phenomena.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a traditional Chinese medicine patch for treating gastrointestinal dysfunction and a preparation method thereof. Background technique [0002] Gastrointestinal dysfunction is a common clinical functional intestinal disease, accounting for about 30% of gastrointestinal diseases, especially in young and middle-aged people. The prevalence of gastrointestinal dysfunction in adults is 10% to 22%, and it is slightly more common in women. Its main clinical manifestations are abdominal pain, diarrhea, constipation and other digestive system symptoms. The etiology is gastrointestinal dysfunction. With the quickening of people's pace of life, the prevalence of the disease is on the rise. Because modern medicine is still unclear about its pathology and pathogenesis, there is still a lack of ideal therapeutic drugs in clinic. Traditional Chinese medicine believes that this disea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/284A61K9/70A61P1/00A61K125/00
Inventor 钱一帆杨星昊吴建波陈素玲
Owner NANJING ZHONGKE PHARMA