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Medicinal composition containing montelukast and statins medicament

A technology of montelukast sodium and its composition, which is applied in the field of medicine, can solve problems that have not been reported, and achieve good therapeutic effects, strong effects, and reduced incidence

Active Publication Date: 2013-04-24
JIANGSU LONGCHANG CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And montelukast sodium and statins are used as a compound to treat respiratory diseases, and there is no report in the prior art

Method used

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  • Medicinal composition containing montelukast and statins medicament
  • Medicinal composition containing montelukast and statins medicament
  • Medicinal composition containing montelukast and statins medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 tablet

[0031]

[0032] Preparation process: Mix pravastatin, montelukast sodium and auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0033] The preparation of embodiment 2 tablet

[0034]

[0035] Preparation process: Mix rosuvastatin, montelukast sodium and auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 3

[0036] The preparation of embodiment 3 tablet

[0037]

[0038] Preparation process: Mix rosuvastatin, zafirlukast sodium and auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

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Abstract

The invention belongs to the technical field of medicaments, provides a medicinal composition containing montelukast and a statins medicament, and discloses application of the medicinal composition to the preparation of a medicament for treating asthma diseases. Specifically, the medicinal composition contains two medicinal active ingredients, i.e., montelukast and a 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor, wherein the mass ratio of the montelukast to the HMG-CoA reductase inhibitor is 1:(0.01-10). Moreover, a compound preparation can be prepared into an oral administration preparation or a parenteral administration preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition of montelukast and statins. Background technique [0002] Bronchial asthma (abbreviated as asthma), its incidence is increasing year by year, seriously threatening public health. Asthma is a kind of chronic airway inflammation, which is a chronic inflammation of the airway involving a variety of inflammatory cells. It is characterized by reversible airway obstruction and increased airway reactivity. Airway obstruction is caused by increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; and increased airway reactivity is also due to airway inflammation. result of damage to the bronchial epithelium. It has been recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma sy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/47A61K31/505A61P11/06
Inventor 刘树芹
Owner JIANGSU LONGCHANG CHEM
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