Optical sectioning of samples and detection of particles in samples

An optical detection and sample technology, applied in optics, optical components, measuring devices, etc., can solve the problems of unreachable goals, poor statistical certainty, limited sample volume, etc.

Active Publication Date: 2011-12-28
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Especially when the method described by Olesen et al. in International Patent Application Publication No. WO 2008 / 010761 is used to measure the distribution of different leukocytes, the method may fall short of the target
Accurate statistics are important in this case, but due to limited sample volume, statistical certainty may be poor if the number of one or more leukocyte species is low

Method used

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  • Optical sectioning of samples and detection of particles in samples
  • Optical sectioning of samples and detection of particles in samples
  • Optical sectioning of samples and detection of particles in samples

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Embodiment Construction

[0123] The figures are schematic and may have been simplified for clarity. Herein, the same reference numerals are used to designate the same or corresponding parts.

[0124] The scope of applicability of the present invention will further appear from the detailed description provided below. However, it should be recognized that the following detailed description and specific examples, including the preferred embodiments of the present invention pointed out at the same time, are provided for illustration only and do not limit the scope of the present invention, because according to such detailed description, in Various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art.

[0125] The invention is defined by the features of the independent claims. Preferred embodiments are defined in the dependent claims. The citation relationship between the claims is not intended to limit the scope of protection thereof. ...

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Abstract

The invention relates to an apparatus, a method and a system for obtaining a plurality of images of a sample arranged in relation to a sample device. The apparatus comprises at least a first optical detection assembly having an optical axis and at least one translation unit arranged to move the sample device and the first optical detection assembly relative to each other. The movement of the sample device and the first optical detection assembly relative to each other is along a scanning path, which defines an angle theta relative to the optical axis, wherein theta is larger than zero.

Description

technical field [0001] The present invention relates to methods, devices and systems for optical sectioning of samples. The sample may be a confined heterogeneous liquid sample containing particles, the optical sectioning of which can be used to determine one or more parameters characterizing said particles. The invention also relates to determining the volume of a confined sample to determine the concentration of particles in that volume. The aforementioned particles may be of biological origin, such as embryos, bacteria, parasites, fungi or cells. Cells may be blood cells such as red and white blood cells, somatic cells, yeast cells, oocytes, blast cells, cygotes, and platelets. The aforementioned particles can also be of non-biological origin, such as metal fragments, water droplets in oil, or air bubbles in liquids, pigments in paints and pollutants in water. It is often necessary to determine the concentration of particles in a sample, for example when diagnosing a pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/36H04N13/239
CPCG01N15/1434H04N13/0055G01N17/00G01N2015/1445G06T7/0012H04N13/0296H04N13/0239G06T2207/30024G01N15/1475G01N2015/1006G02B21/367G01N2015/1452G06T2207/10016H04N13/239H04N13/189H04N13/296G02B21/002G02B21/36G01N15/04G06V20/693G06T2207/10061G06T2207/30101
Inventor T·欧勒森M·C·威维克N·A·拉森R·H·桑德伯格
Owner KONINKLJIJKE PHILIPS NV
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