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Mupirocin ointment and preparation method thereof

A technology of mupirocin and ointment, which is applied in the field of drug synthesis, can solve the problems of unsatisfactory drug effect and poor stability, and achieve the effect of high stability and good drug effect

Active Publication Date: 2013-04-17
BEIJING UNION PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the mupirocin molecule contains epoxy groups, it is unstable in case of acid and alkali, so the existing mupirocin ointment has the problems of poor stability and unsatisfactory drug effect

Method used

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  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] formula:

[0029]

[0030] Preparation method: Dissolve 1 g of citric acid in 391 g of polyethylene glycol 400, then add 98 g of polyethylene glycol 4000, heat to melt in a water bath at 60 ° C, then add 10 g of mupirocin, Stir in a water bath at ℃ to dissolve mupirocin, mix evenly, and cool to room temperature to obtain mupirocin ointment.

Embodiment 2

[0032] formula:

[0033]

[0034] Preparation method: Dissolve 0.2 g of tartaric acid in 317 g of polyethylene glycol 400, then add 179.8 g of polyethylene glycol 4000, heat to melt in a water bath at 55° C., then add 3 g of mupirocin, and Stir in a water bath at 55°C to dissolve mupirocin, mix evenly, and cool to room temperature to obtain mupirocin ointment.

Embodiment 3

[0036] formula:

[0037]

[0038] Preparation method: Dissolve 2g of lactic acid in 420g of polyethylene glycol 400, then add 53g of polyethylene glycol 4000, heat in a water bath at 60°C until melted, then add 25g of mupirocin, and heat at 60°C Stir in a water bath to dissolve mupirocin, mix evenly, and cool to room temperature to obtain mupirocin ointment.

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Abstract

The invention relates to a mupirocin ointment which comprises the following components in percent by weight: 0.5-5 percent of mupirocin, 60-89 percent of polyethylene glycol 400, 10-36 percent of polyethylene glycol 4000 and 0.04-0.4 percent of organic acid. The invention also discloses a preparation method of the mupirocin ointment. Because the mupirocin ointment provided by the invention contains the organic acid as a stabilizing agent, compared with the traditional mupirocin ointment, the mupirocin ointment has higher stability and low content of related substances and better treatment effect during clinical application.

Description

technical field [0001] The invention belongs to the technical field of drug synthesis, and in particular relates to a mupirocin ointment and a preparation method thereof. Background technique [0002] Mupirocin (Mupirocin), also known as pseudomonosporic acid A, is an ideal skin surface antibacterial preparation, which was introduced to the market by GlaxoSmithKline in 1985 under the trade name of "Bactroban". . The U.S. FDA approved the drug to be marketed in the U.S. in 1987, and my country approved the production and sale of the drug by Sino-American Smith Kline Pharmaceuticals in 1993. Mupirocin is mainly used for the prevention and treatment of skin bacterial infections caused by Gram-positive cocci, such as impetigo, furunculosis, folliculitis and other primary skin infections, as well as eczema combined infection, ulcer combined infection, trauma combined Infections and other secondary skin infections. The main mechanism of mupirocin's antibacterial effect is to in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/351A61K47/34A61P17/00A61P31/04
Inventor 潘显道吕亚光吕昭云李强赵立敏
Owner BEIJING UNION PHARMA FACTORY
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