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Immunoglobulin Fc (fragment crystalline) targeted single-domain heavy-chain antibody
A single-domain heavy chain antibody, immunoglobulin technology, applied in immunoglobulin, recombinant DNA technology, introduction of foreign genetic material using vectors, etc., can solve the problems of cumbersome preparation process and high production cost
Active Publication Date: 2012-04-04
HIERAND BIOTECH CO LTD
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Compared with single-domain heavy chain antibodies, these antibodies have disa
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The invention provides an immunoglobulin Fc (fragment crystalline) targeted single-domain heavy-chain antibody with has amino acid sequence shown in SEQ ID NO.: 1 and contains four framework regions and three complementarity-determining regions, wherein the framework regions are respectively selected from SEQ ID NO.: 2, SEQ ID NO.: 4, SEQ ID NO.: 6 and SEQ ID NO.: 8, and the complementarity-determining regions are respectively selected from SEQ ID NO.: 3, SEQ ID NO.: 5 and SEQ ID NO.: 7. The invention also relates to nucleic acid for coding the single-domain heavy-chain antibody and polypeptide and a method for preparing the single-domain heavy-chain antibody and polypeptide. The single-domain heavy-chain antibody and polypeptide can be used for preparing regents or materials for testing or purifying antibodies.
Description
technical field [0001] The present invention relates to single domain heavy chain antibody technology (also known as nanobody technology) and genetic engineering antibody technology, in particular to the single domain heavy chain antibody against the Fc segment (fragment crystalline, Fc) of immunoglobulin G (immunoglobulin G, IgG). chain antibody or polypeptide. technical background [0002] Heavy-chain antibody (Heavy-chain antibody) is an antibody that naturally lacks light chains and consists only of heavy chains, and exists in camels, sharks and other animals. Single domain heavy chain antibody (also known as nanobody, VHH antibody, variable domain of heavy chain of heavy-chain antibody) refers to a genetically engineered antibody composed only of the variable region of heavy chain antibody. Compared with ordinary antibodies, single domain heavy chain antibodies have the advantages of small molecular weight, high stability, and good water solubility, and have been widel...
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Login to View More IPC IPC(8): C07K16/42C12N15/13C12N15/63C12N1/21C12N1/19C12N1/15C12N5/10
Inventor 陶勇许杨付金衡涂追
Owner HIERAND BIOTECH CO LTD
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