Amoxicillin potassium clavulanate powder injection and preparation method thereof

A technology of amoxicillin-clavulanate potassium and amoxicillin sodium-clavulanate-potassium is applied in the field of amoxicillin-clavulanate potassium powder injection and preparation thereof, and can solve the problem of unstable potassium-clavulanate monomer, amoxicillin The problems of cillin sodium inducing moisture and complicated preparation process can achieve the effects of stable storage, improved curative effect and good water solubility.

Inactive Publication Date: 2012-04-11
上海恒丰强生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] An object of the present invention is to provide amoxicillin-clavulanate potassium powder injection, to overcome the complex preparation process of the existing amoxicillin-clavulanate potassium compound preparation dosage form, the moisture absorption of amoxicillin sodium and the lack of amoxicillin-clavulanate potassium monomer. Defects such as stability

Method used

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  • Amoxicillin potassium clavulanate powder injection and preparation method thereof
  • Amoxicillin potassium clavulanate powder injection and preparation method thereof
  • Amoxicillin potassium clavulanate powder injection and preparation method thereof

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Embodiment 1

[0018] The amoxicillin-clavulanate potassium powder injection is mainly made of amoxicillin-clavulanate potassium as a main ingredient, and an appropriate amount of co-solvent and soluble filler glucose are prepared by weight percentage, and the co-solvent is sodium carbonate.

[0019] Formula and process:

[0020]

[0021] Production Process

[0022] (1) The raw materials of the above components are fully pulverized, and sieved with a 300 mesh sieve;

[0023] (2) Mix potassium clavulanate and glucose evenly, then add amoxicillin sodium, fully stir the above-mentioned raw materials after sieving, and mix for 30 minutes until uniform;

[0024] (3) Sampling and testing to check the percentage of raw material content, whether the fineness of the powder is up to standard, whether the water content is qualified, etc.;

[0025] (4) Measure and weigh, pack into bags, and fill each bag with 5 grams, 10 grams or 100 grams of the above-mentioned powder to obtain amoxicillin-clavula...

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Abstract

The invention discloses an amoxicillin potassium clavulanate powder injection which is prepared from the following raw materials in percentage by weight: 10% of amoxicillin, 2.5% of potassium clavulanate, 4% of cosolvent and the balance of soluble filler. The invention also discloses a preparation method of the amoxicillin potassium clavulanate powder injection. The test proves that the amoxicillin potassium clavulanate powder injection disclosed by the invention has the characteristics of stability in storage, convenience in transportation, good water solubility and the like and greatly improves the curative effect of the amoxicillin and potassium clavulanate, thereby being a novel broad-spectrum and efficient special powder injection for animals.

Description

technical field [0001] The invention relates to amoxicillin-clavulanate potassium powder injection and a preparation method thereof. Background technique [0002] Amoxicillin is a semi-synthetic broad-spectrum penicillin drug, slightly soluble in water and almost insoluble in ethanol. Strong bactericidal effect, suitable for infections caused by sensitive bacteria (strains that do not produce β-lactamase). However, due to the emergence of more and more pathogenic strains producing β-lactamase, the pathogenic bacteria can easily cause the β-lactam ring in the amoxicillin molecule to be hydrolyzed and lose its activity, resulting in drug resistance. [0003] Clavulanate potassium (Clavulanate Potassium) is an oxypenicillane compound containing a β-lactam ring. It is easily soluble in water, unstable and easy to decompose when exposed to heat, light, and humidity. It has only weak antibacterial activity, but it can It is firmly combined with most β-lactamases to form irrevers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/43A61P31/04A61K31/424
Inventor 宋莉
Owner 上海恒丰强生物技术有限公司
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