Preparation method for schefflera arboricola hayata total saponins
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A technology for extracting total saponins of Aescinus aesculus, which is applied in the field of extracting total saponins of Aesculus aesculus, can solve the problems of small batch, unsuitable for scale-up, low purity, etc., achieve simple steps, save solvent consumption, reduce The effect of environmental stress
Inactive Publication Date: 2012-05-02
苏州北商智业管理咨询有限公司
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Problems solved by technology
[0004] There are few studies on escin in the prior art. Cui Yan et al. "Research on the Separation and Structural Identification of Dioscin in Aescin" mentioned the method of separating different dioscins...
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Embodiment 1
[0013] Take 10Kg of Aescinus rhizome powder, add 100L 90% ethanol to reflux and extract 3 times, each time for 1.5 hours, combine the extracts, filter, recover ethanol under reduced pressure and concentrate, add petroleum ether to degrease, add water to the residue to make up to 10L , concentrated by HNF40-8040 nanofiltration membrane, dried the concentrated solution into a solid, added acetone to recrystallize twice, and dried to obtain 18.2 g of pale yellow escin, with a purity of 85.3% by HPLC.
Embodiment 2
[0015] Take 10Kg of rhizome powder of Aescinus chinensis, add 120L of 60% ethanol to reflux and extract twice, each time for 1.5 hours, combine the extracts, filter, recover ethanol under reduced pressure and concentrate, add petroleum ether to degrease, add water to the residue to make up to 15L , concentrated by HNF70-8040 nanofiltration membrane, the concentrated solution was dried to a solid, added acetone to recrystallize 3 times, and dried to obtain 19.9 g of light yellow total saponins of Aesculus aescini, the purity of which was 84.8% by HPLC.
Embodiment 3
[0017] Take 10Kg of rhizome powder of Aescinus chinensis, add 110L 80% ethanol to reflux and extract 3 times, each time for 1.5 hours, combine the extracts, filter, recover ethanol under reduced pressure and concentrate, add petroleum ether to degrease, add water to the residue to make up to 20L , concentrated by HNF90-8040 nanofiltration membrane, the concentrated solution was dried to a solid, added acetone to recrystallize twice, and dried to obtain 18.8 g of light yellow total saponins of Aesculus aescini, the purity of which was 83.9% by HPLC.
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Abstract
The invention relates to a preparation method for schefflera arboricola hayata total saponins, which is simple and convenient in operation, low in pollution and low in equipment investment. The preparation method comprises the following technical steps of: performing reflux extraction 2-3 times on crude powder of paris polyphylla stems with ethanol of which the concentration is 60 to 90 percent for 1.5 hours at each time, wherein the amount of the ethanol is 10 to 12 times that of the crude powder; combining the extract; filtering the extract; reclaiming the ethanol under reduced pressure and concentrating the ethanol; degreasing the extract by adding sherwood oil into the extract; adding water into the residue until the volume is 1 to 2 times that of the medicinal material; concentrating the solution with a nanofiltration membrane; drying the concentrated solution; recrystallizing the concentrated solution by adding acetone into the concentrated solution; and filtering and washing the crystal to obtain the schefflera arboricola hayata total saponins. The schefflera arboricola hayata total saponins prepared by the method are high in purity and industrial mass production is easy to realize.
Description
technical field [0001] The invention relates to a preparation method of total saponins of aescin, in particular to a method for extracting total saponins of aescin. Background technique [0002] Aescin is also called Aescin, Chonglou, and flea rest. Aescin saponin is derived from the dried rhizome of Aescinus aesculus, a plant of the Liliaceae family. It has the effects of clearing away heat and detoxifying, reducing swelling and relieving pain. Folks are mostly used to treat unknown swollen poison and poisonous snake bites, as well as mumps, tonsillitis, sore throat, mastitis, bruises, etc. [0003] Aescin rhizomes contain diosgenin-3-O-α-D-glucopyranoside (diosgenin-3-O-α-D-glucopyranoside), namely polyphyllin A, diosgenin-3 -O-α-L rhamnopyranosyl (1→4)-β-D-glucopyranoside, pariphyllin [2], pariphyllin A, B, dioscin [ 4], Aescin C, D, E, F[5], G, H, Diosgenin-3-O-α-L-arabinofuranosyl-(1→4)-[α-L -rhamnopyranosyl-(1→2)β-D-glucopyranosyl, diosgenin-hexaacetoxy-3-O-α-L-rha...
Claims
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