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Cell therapy for brain tissue damage

A technique for brain tissue damage and cells, applied in tissue culture, animal cells, vertebrate cells, etc., can solve the problem of limited neural remodeling ability

Inactive Publication Date: 2012-05-09
STEMCYTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the neural remodeling capacity of these cells is limited

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  • Cell therapy for brain tissue damage
  • Cell therapy for brain tissue damage
  • Cell therapy for brain tissue damage

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[0014] It has been pointed out that ES cells can be used to regenerate neurons or glial cells in the brain, thereby treating brain tissue damage. However, ethical and supply considerations limit the use of ES cells. Non-ES pluripotent cells, such as bone marrow mesenchymal stem cells (MSCs) and human umbilical cord blood (hUCB), show promising alternatives. However, not all of these alternatives are acceptable due to the marked decrease in cell number and proliferation / differentiation capacity with age.

[0015] Human umbilical cord blood, due to its pristine properties and easy availability, appears to be a promising candidate for pleiotropic stem cell collection and could provide an interesting alternative candidate for cell therapy applied to brain regeneration. In particular, populations selected by CD34, a surface molecule expressed on precursor cells from hematopoietic, endothelial and neural lineages, were enriched in hUCB and contained high amounts of early precursor ...

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Abstract

Disclosed are methods for conditioning stems cells and using the conditioned stems cells for treating brain tissue damage.

Description

[0001] Related applications [0002] This application claims priority to US Provisional Application No. 61 / 180,243 (filed May 21, 2009), the contents of which are hereby incorporated by reference in their entirety. Background technique [0003] Brain tissue damage, resulting from trauma or disorders such as neurodegeneration and cerebrovascular disease, is a major cause of long-term paralysis. Due to the pluripotency of embryonic stem (ES) cells, they hold great promise for the treatment of brain injury. However, ethical and supply considerations limit their use. The use of non-ES pluripotent cells has been proposed. However, the neural remodeling capacity of these cells is limited. Therefore, there is a need for a method of enhancing its neural remodeling ability. Contents of the invention [0004] The present invention is based at least in part on the unexpected discovery that hypoxia preconditioning (HP) can be used to enhance the neural remodeling and differentiation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/14A61K35/12C12N5/07A61P25/00
CPCC12N5/0647A61K2035/124C12N2500/02A61P25/00
Inventor 林欣荣李鸿徐伟成李谢秀梅
Owner STEMCYTE