Method for extracting salicin

An extraction method and technology for salicin, which are applied in the field of extracting salicin from it, can solve the problems of many impurities in substances, complicated technical operations, poor quality, etc., and achieve simple process methods, high product purity, and improved product quality. Effect

Inactive Publication Date: 2012-05-16
张守力
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] An object of the present invention is to provide a kind of salicylic acid that is easy to operate, high in product recovery rate, good in quality and can meet the requirements of industrialized production in order to solve the problems that the above-mentioned prior art extracts have many impurities, poor quality and complicated technical operation. Glycoside extraction method

Method used

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  • Method for extracting salicin

Examples

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Effect test

Embodiment 1

[0022] Extraction: Add 15 times the amount of water to the raw material, that is, dry willow bark. After soaking at room temperature for 1 hour, the raw material is placed under the action of ultrasonic waves with a power of 80-100W for 3 times, each time for 28 minutes, and then heated and filtered . Heat to 90°C, keep warm for 3 hours, filter, and take the filtrate. twice in a row. The combined filtrates were concentrated under reduced pressure into an extract.

[0023] Purification: The extract is passed through a macroporous resin column that has been treated with 95% alcohol in advance, and the resin column is first eluted with 5 times the volume of water, and then 50% ethanol is used to elute the resin column, the ethanol eluate is collected, and concentrated under reduced pressure , and then recrystallized with 50% ethanol, decolorized, and vacuum dried to obtain about 98% pure salicin.

Embodiment 2

[0025] It is also possible to add 0.03 parts of enzyme to the raw material of water for soaking and enzymolysis, and then extract according to the method of step 1. The enzyme is a compound enzyme, and the compound enzyme is cellulase and distiller's yeast, amylase, protease, lipase , lysozyme, any one or more of the mixture; cellulase and distiller's yeast, amylase, protease, lipase, lysozyme calculated by mass, the ratio is 1:1:0.25:0.5:0.5:0.5; enzymatic hydrolysis time It was 6 hours, and the enzymolysis temperature was 40°C; the enzymolysis time was 1.5 hours, and the enzymolysis temperature was 45°C, and the rest were the same as in Example 1.

Embodiment 3

[0027] (1.) Extraction: Add 20 times of water to the raw material, that is, the dry willow bark, soak at room temperature for 3 hours, heat to 100°C, keep warm for 0.5 hours, filter, take the filtrate, 4 times in a row, combine the filtrate, reduce compressed and concentrated into extract;

[0028] (2.) Purification: the extract is passed through a macroporous resin column treated with 80% ethanol in advance, the resin column is eluted with 30% ethanol, the ethanol eluate is collected, concentrated under reduced pressure, and then recrystallized with 30% ethanol , decolorized, and vacuum-dried to obtain 98.2% pure salicin.

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Abstract

The invention relates to a method for extracting active components traditional Chinese medicine, in particular a method for extracting salicin. The invention solves the problems existing in the prior art that the extract substances have many impurities and bad qualities, and the technical operation is complicated, and so on, and provides the method for extracting salicin. The method comprises extraction and purification, wherein the extraction process comprises ultrasonic wave effect and an enzymolysis process. The method disclosed by the invention has advantages of convenient operation, high product recovery rate and good quality. The method can also achieve the industrialized production requirements, and is suitable for popularization and application.

Description

technical field [0001] The invention relates to a method for extracting effective components of traditional Chinese medicine, in particular to a method for extracting salicin therefrom. Background technique [0002] Willow contains salicin (molecular structure diagram of salicin) ), especially the highest content of salicin in willow bark. Salicin has antipyretic and analgesic effects, and is used for the treatment of diseases such as fever and arthritis. At present, the main ingredient of widely used antipyretic drugs is salicylic acid, but it has been clinically proven to have relatively large side effects, so it should be used with caution in children. Salicin can slowly transform in the human body to release salicylic acid, with few side effects, and is a traditional Chinese herbal medicine. [0003] Salicin is easily soluble in water, but the method of water extraction often results in poor product quality due to the retention of many impurities. When using organic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08
Inventor 张守力
Owner 张守力
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