Method and device for injury potential compensation after spinal cord injury

A technology of injury potential and spinal cord injury, applied in the direction of electrotherapy, electrodes, internal electrodes, etc., can solve the problems of unknown mechanism of axon regeneration, no basis for electrical stimulation parameters, and restrictions on the application of spinal cord injury, and achieve a relatively stable effect

Active Publication Date: 2012-06-27
INST OF ELECTRICAL ENG CHINESE ACAD OF SCI
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Problems solved by technology

Oscillating electric field stimulation has been used to treat spinal cord injury for more than 20 years. Although the first phase of clinical trials and a large number of animal experiments have shown that oscillating electric field stimulation can promote axon regeneration after spinal cord injury, the mechanism by which oscillating electric field stimulation promotes axo

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  • Method and device for injury potential compensation after spinal cord injury
  • Method and device for injury potential compensation after spinal cord injury
  • Method and device for injury potential compensation after spinal cord injury

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0023] Injury potential refers to the DC potential difference between the injured part and the normal part after spinal cord injury. It is due to the change of the spinal cord microenvironment after the injury, the normal cell membrane and resting potential are destroyed, and the damaged Na + , Ca 2+ It is formed when a large number of cations flow into the cell and anions flow out. As a result, intracellular Ca 2+ Excess, and then trigger a series of biological processes, resulting in secondary damage to the spinal cord. Therefore, after the injury, the microenvironment in the organism is kept stable, and the Ca 2+ Iso-cation influx is an effective means to reduce the degree of injury and improve the prognosis. Preventing the influx of cations can be achieved by stimulating the external electric field and changing the direction of ion flow...

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Abstract

The invention discloses a method and a device for injury potential compensation after spinal cord injury. The method comprises the following steps of: detecting an injury potential after spinal cord injury, observing the value of injury potential in real time, and controlling a stimulation voltage according to the observed value of injury potentials to allow the injury potential close to zero. The method achieves injury potential compensation to ensure that the spinal cord microenvironment is relatively stable. The device for implementing the compensation method comprises four stimulating electrodes, a stimulation voltage generating circuit (2), an injury potential measuring electrode, an injury potential amplifying circuit (4) and voltage display equipment (5). The stimulation voltage generating circuit (2) generates an adjustable stimulation voltage, the stimulation voltage is applied onto the spinal cord of a patient through the stimulating electrodes to stimulate the spinal cord, the injury potential measuring electrode is used for measuring an injury potential, the injury potential amplifying circuit (4) magnifies the injury potential and filters off high-frequency interference in the injury potential, the voltage display equipment (5) displays the value of magnified injury potential, and the stimulation voltage is regulated according to the value of magnified injury potential.

Description

technical field [0001] The invention relates to a treatment method and device for spinal cord injury, in particular to a damage potential compensation method and an electrical stimulator thereof. Background technique [0002] The reconstruction of motor and sensory function after spinal cord injury is one of the major challenges in neuroscience research, and many therapies are currently devoted to promoting the repair of injury. Since the mid-1980s, foreign scholars have successively reported that the application of electric field stimulation can promote the growth of nerve axons to the cathode, reduce the formation of glial scars after injury, and create a good environment for nerve regeneration after central nervous system injury. In order to achieve bidirectional growth of damaged nerves, oscillating electric field stimulation can be used, that is, the polarity of the electric field is exchanged at regular intervals. The current oscillating electric field stimulators mos...

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Application Information

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IPC IPC(8): A61N1/20A61N1/05
Inventor 张广浩霍小林
Owner INST OF ELECTRICAL ENG CHINESE ACAD OF SCI
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