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Application of esculetin

A esculetin and molecular formula technology, applied in the field of esculetin, can solve problems such as no treatment methods, achieve the effect of reducing the size of cerebral infarction and improving neurobehavioral ability

Inactive Publication Date: 2012-07-04
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although researchers have actively intervened against these injury mechanisms of cerebrovascular diseases, there is no effective treatment except early application of tissue plasminogen activator thrombolysis

Method used

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  • Application of esculetin
  • Application of esculetin
  • Application of esculetin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0032] 1. Mouse model of middle cerebral artery ischemia:

[0033] 1. Mice

[0034] ICR male, 23-25g

[0035] 2. Thread bolt

[0036] 6-0 Nylon wire, the end is coated with silicone to make it a plug with a diameter of approximately 0.22mm

[0037] 3. Operation process

[0038] Inject 350mg / kg chloral hydrate intraperitoneally for anesthesia, insert the thread plug from the right external carotid artery to the internal carotid artery to the beginning of the middle cerebral artery, block its blood flow for 75 minutes, then pull out the thread plug to achieve reperfusion .

[0039] 2. Neurobehavioral score

[0040] After 24 hours of ischemia-reperfusion, neurobehavioral scores were performed in mice:

[0041] 0 points: no symptoms of neurological deficit;

[0042] 1 point: The contralateral forelimb is adducted when the tail...

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Abstract

The invention discloses an application of esculetin (6,7-dihydroxy coumarin), wherein the molecular formula of the esculetin is C9H6O4, and the chemical structural formula of the esculetin is described in the specification. The esculetin is used for protecting the brain of a rat from ischemia reperfusion damage. In the ischemia reperfusion damage model of the median of the rat brain, the injection of the esculetin for a laboratory rat can obviously reduce the cerebral infarction area and the neurobehavioral capability of the rat is improved.

Description

[0001] technical field [0002] The present invention relates to a kind of aescin, specifically, relates to the application of a kind of aescin. [0003] Background technique [0004] Cerebral stroke is a group of acute cerebrovascular diseases caused by acute hemorrhage or ischemia of brain tissue, resulting in paralysis, speech impairment, limb numbness, dizziness, nausea, vomiting, unsteady walking, coma, and even death. It is characterized by high disability rate, high mortality rate and high recurrence rate. In the ranking of causes of death among Chinese residents published by the Ministry of Health in 2008, cerebrovascular disease has become the first cause of death. Stroke not only causes damage to human health and threatens life, but also brings heavy medical, economic and social burdens to patients, their families and society. According to statistics, fatal cerebral apoplexy accounts for 27%, and most stroke patients survive with residual paralysis, aphasia and ...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61P9/10
Inventor 徐兴顺刘春风裴爱杰陈静于海龙王琛
Owner SUZHOU UNIV
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