57 results about "Laboratory rat" patented technology

The utility model relates to a water feeding structure for experimental animal feeding, which comprises a water inlet pipe, a water outlet pipe and a water outlet pipe, the drainage assembly is installed at the bottom of the water inlet pipe, and the drainage assembly is used for guiding water of the water inlet pipe into the cage. According to the water feeding structure for experimental animal feeding, the drainage assembly is arranged, water of the water inlet pipe can be guided into the drainage groove of the drainage block, opening and closing of the drainage groove are achieved through the locking mechanism, the hidden drinking design can avoid the problem that a water source is exposed in the air for a long time and is polluted and deteriorated, and the service life of the water feeding structure is prolonged. The problem that bacteria breed in the cage due to damp when the water basin is overturned can be avoided, and the water drinking requirements of a plurality of laboratory mice can be met at the same time.

The application provides a laboratory mouse tail skinner and an operating method thereof, which comprises a base, a cutting mechanism comprising a first assembly ring and a plurality of cutting assemblies, any cutting assembly comprising a first mounting seat and a cutting knife, the cutting knife being arranged on the first mounting seat and extending towards the center of the first assembly ring, and a skinning mechanism comprising a second assembly ring and a plurality of skinning assemblies, the second assembly ring being arranged concentrically with the first assembly ring, and the skinning assembly comprising a second mounting seat and a skinning knife, the skinning knife being connected to the second mounting seat and facing along the axial direction of the second assembly ring. The application replaces manual operation of a handheld blade with a mechanical structure, effectively avoiding the safety hazard of a sharp blade scratching the fingers of a laboratory worker. In addition, the application has a simple body structure and is convenient to assemble, can flexibly adjust the positions of the cutting assemblies and the skinning assemblies according to laboratory mouse tails of different specifications, has a wide range of applications, and has high practicality and promotional value.

The invention discloses a laboratory mouse feed and a preparation method thereof. The feed consists of the following raw materials in percentage by weight: 32-38% of corn flour, 22-28% of fermented soybean meal, 8-12% of fish meal, 4-6% of silkworm chrysalis meal, 10-15% of low-gluten wheat flour, 2-3% of purple perilla seed oil, 1.5-2.5% of calcium carbonate, 0.8-1.2% of calcium hydrophosphate, 0.3-0.5% of table salt, 0.8-1.2% of microencapsulated compound vitamins, 0.2-0.4% of an enzyme preparation compound, 3-5% of dietary fibers and the balance of mineral premix. The preparation method has the beneficial effects that the vitamin retention rate of the technical scheme is increased by 30-40% compared with a contrast, and the problem of nutrient loss caused by a traditional high-temperature process is solved; the water uniformity is improved by 68% through gradient cooling, the quality guarantee period is prolonged from 50 days to 85-95 days in combination with a microencapsulation technology, and the storage loss is reduced.

The utility model discloses a rat binding device for experimental acupuncture, which comprises a bottom plate, a first support frame is fixedly mounted at one end of the top of the bottom plate, a second support frame is fixedly mounted at the other end of the top of the bottom plate, a placing component is rotatably mounted between the first support frame and the second support frame, and the outer side of the placing component is in meshed connection with a turnover component. The fixing assembly is installed in the middle of the top face of the containing assembly, the adjusting assemblies are fixedly installed at the two ends of the two sides of the containing assembly, and the binding assemblies are fixedly installed at the tops of the adjusting assemblies and the tops of the containing assembly. An experimenter can easily turn a rat from a supine position to a prone position, and acupuncture points of different parts can be conveniently and quickly exposed; through the adjusting assembly, it is ensured that the laboratory mouse is stably and comfortably fixed, and it is avoided that the accuracy of acupuncture operation and the reliability of experimental data are affected due to infirm fixing.

This utility model relates to a simple experimental mouse fixation and tail vein injection device, including a fixation platform, a transparent isolation cover, and a tail fixation component. The transparent isolation cover is used to cover the experimental mouse on the fixation platform. An isolation cover notch is formed at the edge of the open end of the transparent isolation cover, through which the tail of the experimental mouse protrudes. The tail fixation component is used to fix the protruding tail of the experimental mouse on the fixation platform. This utility model combines experimental mouse fixation, tail fixation, and visual monitoring, achieving a dual improvement in drug administration accuracy and simplified experimental operation. It can be operated by a single person and is suitable for precise drug delivery and real-time image monitoring in small animal experiments, possessing high practical value and promising prospects for widespread application.

The invention relates to the technical field of orthodontic tooth movement in animal experiments, in particular to a mouse orthodontic tooth movement model and a construction method thereof, and the mouse orthodontic tooth movement model comprises a traction assembly and an anchorage nail; the laboratory mouse is provided with a maxillary bone, second molar teeth growing on the maxillary bone and incisors growing on the maxillary bone, first molar teeth of the laboratory mouse are extracted, and an avoiding space is formed in front of the second molar teeth after the first molar teeth are extracted; the anchorage nail is connected to the maxillary bone and is positioned between the second molar and the incisors; the anchorage nail is fixed after being implanted into the maxillary bone, so that the position change of the traction assembly caused by connecting the traction assembly to the incisors can be avoided; the traction assembly is arranged between the second molar and the anchorage nail, the front end of the traction assembly is connected with the anchorage nail, the rear end of the traction assembly can penetrate through the avoiding space and is connected with the second molar, the second molar is used as an experimental moving tooth, and the movement rule of human clinical orthodontic teeth can be better simulated.

The invention relates to a construction method of an experimental autoimmune prostatitis rat model. The construction method comprises the following steps: S1, preparing a prostate specific antigen mixture; s2, selecting male SD rats as laboratory rats, and dividing the laboratory rats into a normal saline control group, a low-dose model group and a high-dose model group; s3, continuously injecting for 7 days, allowing the normal saline control group to accept injection of 0.2 ml of normal saline every day, allowing the low-dose model group to accept injection of 0.1 ml of prostate specific antigen mixture every day, and allowing the high-dose model group to accept injection of 0.2 ml of prostate specific antigen mixture every day; and S4, continuously feeding all groups of experimental mice to the 28th day, inducing the experimental mice in the low-dose model group and the high-dose model group by the prostate specific antigen mixture to cause experimental autoimmune prostatitis, and obtaining the experimental autoimmune prostatitis rat model. The use of animals can be reduced, the cost is reduced, and the modeling efficiency and stability can be improved.

The utility model belongs to the field of biological experiment instruments, and discloses an auxiliary device suitable for electroacupuncture intervention of acupuncture points on the head and the back of an experimental mouse. The auxiliary device comprises an experiment box and a bridle, wherein the experiment box is provided with a moving cavity for the laboratory mouse to move; the band is annular and is sleeved and tightened on the abdomen of the laboratory mouse, so that acupuncture points on the head and the back can be completely exposed in front of researchers, and the electric needles can conveniently pierce the acupuncture points on the head and the back of the laboratory mouse. The electric needle wire penetrates into the binding ring of the binding belt and is connected with the electric needle penetrating into the acupuncture points of the head and the back of the laboratory mouse, so that the electric needle wire is fixedly attached to the back of the laboratory mouse through the binding belt, and the laboratory mouse can be prevented from scratching and biting to affect the experiment. After the experimental mouse with the bridle is put into the experimental box, the experimental box can provide a limited environment in which the experimental mouse can move in a small range for the experimental mouse, so that the stimulation and environmental pressure on the experimental mouse are reduced, the anxiety or depression probability of the experimental mouse can be reduced, and the experimental mouse can be effectively intervened for a long time.

The invention relates to an efficient energy supply type laboratory mouse feed which comprises the following components in percentage by weight: 20-40% of corn, 10-30% of wheat, 1-5% of wheat middling, 4-10% of soybean meal, 2-8% of fish meal, 2-6% of chicken meal, 1-10% of soybean hull, 1-5% of soybean oil, 1-5% of lard, 0.5-2% of stone powder, 0.5-1.5% of calcium hydrophosphate, 2-5% of premix, 1-5% of MCT microcapsule powder and 0.5-2% of glutamine. The stability of MCT is improved through a microencapsulation method, the activity of glutamine is reserved through an embedding method, the synergistic effect of MCT microcapsule powder and glutamine is utilized, meanwhile, lard oil and fat raw materials are added, high-temperature steam is used for curing materials in the production process, the fragrance of the feed is further improved, the palatability of the feed is jointly improved, the food intake of laboratory mice is not affected, and the production cost is reduced. The utilization efficiency of the feed is improved; the experimental mouse feed can reduce body fat and improve blood lipid level, can effectively prolong exhaustion time of mice, and is suitable for cultivation and maintenance of special experimental animals such as intestinal injury models and immunodeficiency models.

The invention discloses a state recognition method of an adaptive gene editing laboratory mouse, and aims to solve the problem of insufficient state recognition specificity of the gene editing laboratory mouse in the prior art. The method comprises the following steps: acquiring genotypes, disease model types and experimental environment parameters of laboratory mice; optimizing detection and optical flow analysis parameters, generating a time sequence behavior track map and segmenting a key area; extracting general and pathological specific composite features and standardizing the general and pathological specific composite features; calling a genotype pathological feature association database to calibrate a weight and a threshold value, and inputting a random forest classifier recognition state of transfer learning optimization; scores are calculated through a weighted scoring model, the state is judged, and credibility is calculated through a multi-dimensional confidence evaluation model. The method is suitable for various gene editing laboratory mice and experimental environments, the accuracy and suitability of state recognition are improved, and powerful support is provided for gene therapy research and development and disease mechanism research.

The application discloses a retinal light damage box experimental device for observing mouse visual dynamic response, which comprises a reflecting box body, a box cover hinged to one side of the top end of the reflecting box body, the box cover being matched with the reflecting box body, a light irradiation assembly fixedly connected to one side of the box cover close to the inside of the reflecting box body, the inner wall of the reflecting box body being used for reflecting the light emitted by the light irradiation assembly, the light irradiation assembly being electrically connected with a control system, a frequency adjusting assembly fixedly connected to the middle of the bottom end of the reflecting box body, the frequency adjusting assembly being covered on a placing table, the frequency adjusting assembly being correspondingly arranged on the inner wall of the reflecting box body, and a placing assembly fixedly connected to the middle of the top end of the placing table, the experimental mouse being placed in the placing assembly, the light irradiation assembly and the frequency adjusting assembly being correspondingly arranged on the placing assembly. The application realizes dynamic observation of the light damage condition of the experimental animal, avoids repeated experiments, shortens the experimental period and improves the experimental efficiency.

The application relates to a method for constructing an experimental autoimmune prostatitis rat model, which comprises the following steps: S1, preparing a prostate specific antigen mixture; S2, selecting male SD rats as experimental rats and dividing the rats into a physiological saline control group, a low-dose model group and a high-dose model group; S3, continuously injecting for 7 days, wherein the physiological saline control group receives 0.2ml of physiological saline injection every day, the low-dose model group receives 0.1ml of the prostate specific antigen mixture injection every day, and the high-dose model group receives 0.2ml of the prostate specific antigen mixture injection every day; and S4, continuing to feed all the experimental rats in the groups until the 28th day, wherein the experimental rats in the low-dose model group and the high-dose model group are induced by the prostate specific antigen mixture to cause experimental autoimmune prostatitis, and an experimental autoimmune prostatitis rat model is obtained. The method can not only reduce the use of animals and the cost, but also improve the modeling efficiency and stability.

The invention provides a visual quantitative gavage device for laboratory mice, and particularly relates to the technical field of biological experiment instruments.The visual quantitative gavage device comprises a fixed bottom plate, a supporting frame is fixedly connected to the center of the top face of the fixed bottom plate, the laboratory mice are restrained in the mode that the belly faces downwards in the laboratory mouse restraining process, and the situation that when an experimenter manually restrains the laboratory mice, the laboratory mice are restrained by the supporting frame is avoided; according to the lavage device, four limbs of an experimental mouse easily scratch the hand of an experimenter, after the experimental mouse is restrained and fixed, the body of the experimental mouse can be automatically turned over by 180 degrees, so that the experimental mouse is finally inclined upwards, and the experimenter can conduct lavage operation conveniently, and compared with the mode that the experimental mouse is manually held by hand and then the abdomen of the experimental mouse is inclined upwards, the lavage operation is more convenient. The automatic rotating mode is more convenient, the laboratory mouse can be stably kept in the overturned posture, the situation that in the prior art, lavage operation is unstable only by holding the laboratory mouse manually is avoided, and the stability and safety of lavage operation of the laboratory mouse are improved.

The utility model discloses a device convenient for exploring laboratory mouse habits, which comprises a laboratory mouse habit exploring device, a plurality of independent control cabins are arranged in an upper box body of the laboratory mouse habit exploring device at equal angles, and ventilation openings are arranged above the outer arc-shaped side walls of the independent control cabins in a matched mode. A plurality of independent control cabins are arranged on the experimental mouse habit exploration device, humidity controllers and controllable illuminating lamps are arranged in top covers of the independent control cabins at equal angles, temperature control tubes are arranged at the bottoms of the independent control cabins, the independent control cabins are communicated with the central multi-through groove, the experimental mouse habit exploration device is provided with the independent control cabins, and each independent control cabin can achieve simulation of different environments. In this way, the adaptive capacity of the mouse to the environment can be better explored, different external environments can generate different environmental stimuli to the mouse, the external environments can well induce the animal to generate immune response aiming at the myelin sheath component of the central nervous system (CNS), research data can be well compared, and the research result is more accurate. And the data accuracy is higher.

An integrated CUMS reaction box comprises a box body, at least two spaces for independently bearing mouse cages are arranged in the box body, laboratory mice are arranged in the mouse cages, a box door is movably connected to the side face of the box body, and each space of the box body is correspondingly provided with a lighting mechanism, a sound production mechanism, a heating mechanism, a support mechanism and a water supply mechanism which are used for the mouse cages. The lighting mechanism, the sound production mechanism, the heating mechanism, the support mechanism and the water supply mechanism are integrated in a single box body, various pressure stimulations can be performed on laboratory mice in a mouse cage of the single box body, on one hand, various independent experiment devices are integrated, and the situation that a large space is occupied during an experiment is avoided; 2, the physical stress reaction of the experimental mouse is prevented from being increased by transferring the experimental mouse, and the operation complexity is reduced; and thirdly, variable parameters in the box body are convenient to adjust, the accuracy of parameter regulation and control is improved, and the consistency of experimental results is improved.

The utility model relates to the technical field of experimental animal model feed, and discloses an experimental mouse selenium deficiency model feed powder mixing machine which comprises a first supporting frame, a first stirring tank is installed at the top of the first supporting frame, the top of the first stirring tank is communicated with a connecting pipe, a filter plate is fixedly connected into the connecting pipe, and a second stirring tank is installed at the top of the first supporting frame. The top of the connecting pipe communicates with a second stirring tank, a second motor is installed in the middle of the top end of the second stirring tank, the output end of the second motor is fixedly connected with a rotating short column, the bottom of the rotating short column penetrates through the top of the second stirring tank, and a plurality of stirring rods are fixedly connected to the outer side of the rotating short column at equal intervals. Materials enter the second stirring tank from the feeding pipe, the second motor is started, the rotating short column drives the stirring rod to rotate, the materials are mixed preliminarily and evenly, the materials flow to the first stirring tank through the connecting pipe, the filter plate in the connecting pipe filters the materials, uniformity is guaranteed, and working efficiency is improved.

The utility model relates to the technical field of laboratory mouse cages, in particular to a clamping type quick-disassembly laboratory mouse cage body structure, and aims to solve the problem that a cage body is inconvenient to disassemble, the clamping type quick-disassembly laboratory mouse cage body structure comprises a bottom shell and a disassembly mechanism, the disassembly mechanism is arranged above the bottom shell, and the disassembly mechanism comprises a top shell arranged above the bottom shell; two T-shaped sliding grooves are formed in the upper surface of the bottom shell, and the inner wall of each T-shaped sliding groove is slidably connected with a T-shaped sliding strip. Through cooperation of a tension spring, a U-shaped plate and an insertion plate, the insertion plate can move up and down, then positioning of the top shell can be relieved after the insertion plate moves upwards, through cooperation of a T-shaped sliding groove and an elastic sliding strip, the top shell moves in the direction of the T-shaped sliding groove, the top shell can be rapidly separated from the bottom shell, the top shell can be detached conveniently, and the practicability is high. The frame body can be positioned through the spring pieces, so that the frame body can slide upwards when being pulled, the mouse separation net can be conveniently detached, and the interior of the mouse separation net can be conveniently cleaned.

The utility model relates to the technical field of experiment auxiliary equipment, in particular to an auxiliary device for an explosion experiment. The first conical barrel is provided with a first end and a second end, the first end and the second end are opened, the diameter of the opening of the first end is smaller than that of the opening of the second end, the second end is detachably connected with one end of the barrel, and a first positioning hole is formed in the first conical barrel and used for exposing a preset part of the head of an experimental mouse; the second conical barrel is arranged on the first conical barrel in a sleeving mode, a second positioning hole is formed in the side wall of the second conical barrel, the second positioning hole corresponds to the first positioning hole in position, and the area of the second positioning hole is smaller than that of the first positioning hole. The experimental mouse head exposure device has the advantages that when the experimental mouse head exposure device is used, the second positioning hole covers the first positioning hole, so that the head part of an experimental mouse is finely exposed, the part needing to be researched is accurately exposed, and subsequent research on explosion impact injury is facilitated.

The present application relates to experimental apparatus technical field, specifically to a kind of experimental mouse multifunctional incubator;Including the box of cylindrical, box includes bottom plate, top plate and barrel, bottom plate top surface middle part is equipped with vertical baffle, baffle is along the diameter direction of box and baffle both sides are respectively with the fixed connection of corresponding side of barrel, baffle is divided into two cavities, baffle top is equipped with moving partition device, moving partition device moves along the length direction of baffle, and moving partition device further divides the cavity of two sides into feeding space, and the size of feeding space is adjusted by moving partition device movement, and barrel is equipped with door plate corresponding each feeding space;The present application is moved by slider and moves the baffle of two sides, not only fully utilize the space inside box, the size of feeding space is adjusted by the rotation of baffle and the movement of slider, it is convenient to observe experimental mouse;And baffle moves and drives experimental mouse to the side of door plate, it is convenient to take out experimental mouse.

The utility model relates to an anti-bite mouse laboratory garment which comprises a laboratory garment body, hook-and-loop fasteners are installed on the front face and the back face of the laboratory garment body, hook-and-loop fastener strips are connected to the right side of the laboratory garment body, a label plate is installed on the front face of the laboratory garment body, and auxiliary mechanisms are arranged inside and outside the laboratory garment body. The auxiliary mechanism comprises an arc-shaped groove. According to the anti-bite mouse laboratory clothes, firstly, a mouse is placed on the hook face of the hook-and-loop fastener of the laboratory clothes body, the neck of the mouse is clamped in the arc-shaped groove, then the hook-and-loop fastener strip is pulled leftwards, the tightness of the laboratory clothes body is adjusted, the laboratory clothes body wraps the mouse, at the moment, the anterior limb and the posterior limb of the mouse penetrate through the anterior limb positioning hole and the posterior limb positioning hole respectively, and then the mouse is placed on the laboratory clothes body. When the mouse is used, the mouse enters the limiting sleeve, then the ribbons on the left side and the right side are fastened, so that the mouse can be better adapted to laboratory mice of different sizes, finally the zipper is unzipped according to needs, the abdomen of the mouse is exposed, and recording is carried out on the label plate on the back of the mouse.

The invention relates to a laboratory mouse tail lineation marking pen which comprises an outer opening ring, the inner side of the outer opening ring is slidably connected with an inner opening ring, a guide plate is fixed to the outer circumferential wall of the inner opening ring, and a guide groove allowing the guide plate to be slidably connected is formed in the inner circumferential wall of the outer opening ring. An opening sponge block is fixed to the inner side of the inner opening ring, and a control assembly is arranged on the outer opening ring. When the experimental mouse tail lineation marking pen is used, an opening sponge block is conveniently controlled to wrap the tail of an experimental mouse through the arranged control assembly, then the control assembly controls an inner opening ring to rotate on the inner side of an outer opening ring, and the inner opening ring drives the opening sponge block to rotate to generate friction with the tail of the experimental mouse; according to the experimental mouse marking device, automatic circle-turning marking is achieved through the control assembly, the whole process is easier and faster to operate, the marking efficiency and convenience are greatly improved, practicability is better, and application and popularization are more convenient.

The invention relates to the technical field of rat experiment assistance, in particular to an experimental rat binding device which comprises a base, a rubber pad is fixedly connected to the base, a limb positioning mechanism is arranged on the rubber pad, and a head positioning mechanism is arranged on the rubber pad. The four-limb positioning mechanism comprises two magnetic plates, magnetic blocks are connected to the magnetic plates in a magnetic attraction mode, mounting blocks are fixedly connected to the top ends of the magnetic blocks, symmetrically-arranged supports are fixedly connected to the mounting blocks, telescopic air bags are fixedly connected to the interiors of the supports, conveying pipes are fixedly connected to the telescopic air bags, and the conveying pipes are fixedly connected to the conveying pipes. The device has the advantages that the adaptability is remarkably improved, the elastic band does not need to be frequently replaced, flexible adaptation to rats of different body types is achieved through magnetic attraction adjustable positioning of the magnetic blocks and the magnetic plates and the telescopic characteristic of the telescopic air bag, the problems that a traditional elastic band is fixed in length and poor in adaptability are thoroughly solved, and the experiment operation efficiency is greatly improved.

The application provides a device and method for auxiliary culture and detection of a liver cancer animal model, which comprises a box, an experimental mouse culture and detection room in the box, a fixing cavity in the culture and detection room, a fixing assembly in the fixing cavity, a pair of parallel and opposite side plates, a reversible clamping plate vertically connected between the pair of side plates and used for fixing an experimental mouse, an inclined plate rack horizontally and obliquely arranged and used for supporting and fixing the side plates, a support plate parallel arranged longitudinally below the clamping plate, a head pinching rod and a trunk pinching rod installed on the support plate and used for pinching and fixing the skin of the experimental mouse, a weighing cavity connected with the fixing assembly through a moving assembly, and a detection cavity comprising diagnostic equipment, wherein the experimental mouse is transferred to the longitudinal direction below the diagnostic equipment through the moving assembly for detection and diagnosis.

The application claims an image recognition-based automatic tracking method and system for wound area of experimental mice, which regularly collects images of the wound area through a multispectral imaging device, and synchronously records parameters such as environmental light and shooting distance during the collection process to ensure data consistency, pre-processes the images using a distributed computing system, inputs the pre-processed images into a deep segmentation model trained based on a large data set to accurately identify and output a binary contour mask of the wound area, calculates wound geometric features based on the mask, dynamically generates a quantitative report including an area change rate and a healing trend coefficient, and stores all time series data in a time series database to construct a complete wound healing trajectory atlas, and supports visualization and trend analysis of the healing process. The application realizes high-throughput and automatic quantitative monitoring of the wound healing process of experimental mice, and significantly improves the objectivity and analysis efficiency of animal experiment data.

The application relates to the technical field of medical experiments, and discloses a semi-immersion type stroke experimental mouse rehabilitation training device, a screen is arranged on a base; a supporting platform is arranged on the base, one end of the supporting platform is rotationally connected with two groups of limb rotating shafts, the two ends of the two groups of limb rotating shafts are arranged to extend from the side surface of the supporting platform and are provided with pedals; a driving mechanism is arranged at the other end of the supporting platform, and the output end of the driving mechanism is connected with the limb rotating shafts; a rotating speed sensor for detecting the rotating speed of the output end of the driving mechanism is further arranged on the base, an experimental mouse is prone on the supporting platform, limbs are fixed on the pedals, the image playing speed of the screen is matched with the rotating speed to realize the coupling of the visual field and movement; the semi-immersion type task-oriented upper limb training can be completed in the mode of the coupling of the visual field and movement, the mouse can generate changes in movement planning and spatial position sense, the method of visual stimulation combined with movement training is used to improve the post-stroke neural plasticity and functional recovery of the mouse, and the in-depth exploration of the semi-immersion type neural rehabilitation mechanism is facilitated.

The invention discloses a laboratory mouse model construction method for post-traumatic stress disorder research, which comprises the following steps: step S01, putting a laboratory mouse into a conditional fear test box, and adapting to the environment of the conditional fear test box; s02, applying conditional stimulation to the laboratory mouse for a first preset time, wherein the conditional stimulation comprises sound signal stimulation or constraint stress; before or when the conditional stimulation is finished, electric shock is applied to the laboratory mouse for a second preset time, and the current of the electric shock is 1.2-1.6 mA; and S03, repeating the step S02 for preset times, and obtaining the laboratory mouse model for post-traumatic stress disorder research by taking the time interval between two adjacent repetitions as third preset time.

The utility model relates to the technical field of dehydrator equipment, and discloses a laboratory mouse selenium-deficient model feed dehydrator which comprises a heat preservation box, the front side and the rear side of the left portion of the inner wall of the heat preservation box are rotationally connected with a plurality of rotating discs, and the adjacent sides of the two rotating discs on the front side and the rear side are rotationally connected with a screening frame. Sliding blocks are rotationally connected to the front side and the rear side of the right portion of the screening frame, the outer walls of the sliding blocks are slidably connected with the inner wall of the heat preservation box, a servo motor is fixedly connected to the left side of the rear portion of the outer wall of the heat preservation box, and the output end of the servo motor penetrates through the heat preservation box and is fixedly connected with the rotating disc at the top end of the rear side. According to the feed screening device, the servo motor, the rotating disc and the screening frame are started to move, feed is screened and filtered, unqualified feed moves leftwards, slides to the inclined guide plate from the left side of the filter screen and then slides to the filter screen at the bottom, the hot air machine dries the feed, and therefore the feed is prevented from being adhered to the inner wall of the device.

A process of making standard feed based on local ingredients for laboratory rats and mice is disclosed, which includes the following stages: a) preparing ingredients in the form of 290 grams of corn flour, 90 grams of fish meal, 50 grams of bran or fine rice bran, 40 grams of roasted soybeans, 15 grams of bone meal or dolomite, 5 grams of vegetable oil, 5 grams of vitamins or premix, and 5 grams of dried vegetables to obtain a total mixture of 500 grams; b) mixing corn flour, fish meal, bran or fine rice bran, roasted soybeans, bone meal or dolomite, vitamins or premix, and dried vegetables until homogeneous; c) taking 30 grams of the mixture from step b), then mixing it with 5 grams of vegetable oil until evenly distributed; d) mixing the results of step c) again into the remaining mixture from step b) and stirring until homogeneous; e) adding 250 mL of distilled water gradually while stirring until a smooth dough is formed; f) steaming the dough for about 10 minutes;g) let the mixture rest for about 3–5 minutes, then mold it into pellets; and h) dry the pellets at a temperature of about 60°C for about 3 hours. This process produces pellet-shaped feed with a balanced nutritional composition, compact and homogeneous texture, low water content, and stability during storage so that it is suitable for use as standard feed for maintaining laboratory rats and mice in research, preclinical testing, and biomedical science development;

This utility model relates to the field of laboratory animal technology in barrier environments, specifically to an automatic water replenishment device for laboratory mice, comprising a mounting plate, a water storage box, a water replenishment pipe, a control pipe, a control column, a mouse cage, a feeding box, and a feeding assembly; the mounting plate is vertically mounted on a wall, the water storage box is mounted on top of the mounting plate, the water replenishment pipe is disposed inside the water storage box with one end located outside the water storage box, and a water purifier is connected to the outer end of the water replenishment pipe, the control pipe is installed in the middle of the water replenishment pipe, the control column is installed inside the control pipe, the mouse cage is mounted on top of the mounting plate with the cages spaced apart, the feeding box is installed inside the mouse cage, and the feeding assembly is installed inside the mounting plate, with the feeding assembly located above the feeding box.

This invention discloses a passive running device for a mouse with its head fixed, comprising a base plate, a support assembly, a head fixation component, and a running mechanism. The support assembly is disposed on the base plate. The head fixation component is used to fix the head of the mouse and is detachably connected to the support assembly. The running mechanism is disposed on the base plate and includes a driver and a running belt assembly. The head fixation component is located above the running belt assembly to restrain the mouse on the running belt assembly. The driver is driven by the running belt assembly to drive the running belt assembly, enabling the mouse on the running belt assembly to passively perform running movements. This invention, by fixing the head of the mouse and utilizing the movement of the running belt assembly to passively induce running movements, can assist in observing the two-photon neuronal electrical signals of the mouse during running using a two-photon microscopy system, and observe the cerebellar neuronal firing patterns during movement, thus contributing to neuroscience research.