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Xingnaojing self-emulsifying soft capsule and preparation method thereof

A technology of self-emulsifying soft capsules and Xinnaojing, which is applied in the field of medicine to achieve the effect of simple preparation method, rapid distribution and definite curative effect

Active Publication Date: 2015-07-22
WUXI JIYU SHANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

SMEDDS is a thermodynamically stable system with stable properties. At present, there is no report on the development of oral preparations of Xingnaojing by self-microemulsification technology.

Method used

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  • Xingnaojing self-emulsifying soft capsule and preparation method thereof
  • Xingnaojing self-emulsifying soft capsule and preparation method thereof
  • Xingnaojing self-emulsifying soft capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0060] Embodiment 1. Preparation of Xingnaojing Self-emulsifying Soft Capsules:

[0061] Gardenia 300 parts, turmeric 300 parts, musk 75 parts, borneol 10 parts, ethyl oleate 180 parts, Tween 80300 parts, polyethylene glycol 400120 parts;

[0062] (1) Take the musk, turmeric, and gardenia three medicinal materials in the prescription amount, grind them, and use supercritical extraction method to control the extraction pressure to 20-45MP, the extraction temperature is 40°C-60°C, and the analysis pressure is 10-30MP. Temperature 10°C-20°C, extract volatile oil, set aside;

[0063] (2) adding ethyl oleate to the volatile oil mentioned in step (1) and mixing to obtain an oil phase;

[0064] (3) Take the borneol in the prescription amount, add Tween 80, polyethylene glycol 400, grind and mix, mix with a magnetic stirrer, make it dissolve completely, and obtain an emulsified phase;

[0065] (4) Mix the oil phase with the emulsified phase, and mix evenly by stirring, oscillating, ...

Embodiment 2

[0067] Embodiment 2. Preparation of Xingnaojing Self-emulsifying Soft Capsules:

[0068] Prescription: 300 parts of gardenia, 300 parts of turmeric, 75 parts of musk, 10 parts of borneol, 300 parts of ethyl oleate, 250 parts of polyoxyethylene castor oil, 400-100 parts of polyethylene glycol,

[0069] (1) Take the musk, turmeric, and gardenia three medicinal materials in the prescription amount, grind them, and use supercritical extraction method to control the extraction pressure to 20-45MP, the extraction temperature is 40°C-60°C, and the analysis pressure is 10-30MP. Temperature 10°C-20°C, extract volatile oil, set aside;

[0070] (2) adding the volatile oil mentioned in step (1) to glyceryl oleate and mixing to obtain an oil phase;

[0071] (3) Take the borneol in the prescription amount, add soybean lecithin and isopropanol, grind and mix, mix evenly with a magnetic stirrer, and dissolve it completely in medium to obtain an emulsified phase;

[0072] (4) Mix the oil pha...

Embodiment 3

[0074] Example 3: Preparation of Xingnaojing self-emulsifying soft capsules.

[0075] Prescription: 300 parts of gardenia, 300 parts of turmeric, 75 parts of musk, 10 parts of borneol, 300 parts of glyceryl oleate; 300 parts of hydrogenated castor oil, 150 parts of isopropanol,

[0076] Preparation method is the same as embodiment 1

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Abstract

The invention discloses a Xingnaojing self-emulsifying capsule and a preparation method thereof. According to the preparation method, extracts of medicinal materials of the Xingnaojing prescription are matched with an oil phase, an emulsifier and a co-emulsifier to prepare a self-microemulsifying concentrated solution, and the self-microemulsifying concentrated solution is prepared into soft capsules by a conventional method. The preparation method of the Xingnaojing self-emulsifying soft capsule is simple, can improve oral absorption, and has exact and safe curative effect, good stability and controllable quality.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a Xingnaojing self-emulsifying soft capsule and a preparation method thereof. Background technique [0002] The prescription of Xinnaojing is made from the traditional famous prescription of the motherland——"Angong Niuhuang Pill", which is the representative of Liangkai prescription. Among them, musk is resuscitated and refreshed, which is the monarch drug; Gardenia clears away heat, purifies fire and detoxifies, and clears the fire of the pericardium, and is used as the minister drug; turmeric and borneol are fragrant and filthy, open and close to strengthen the effect of musk for rejuvenating and refreshing Adjuvant medicine, make medicine. Xingnaojing injection made according to this prescription is used for the treatment of: 1. Acute cerebral hemorrhage, cerebral infarction pulmonary encephalopathy, epilepsy, central infection, hypertensive encephalopathy, vira...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/48A61P7/04A61P9/10A61P11/00A61P25/00A61P25/08A61P25/28A61P31/00A61P9/12A61P31/12A61P29/00A61K31/045A61K35/55
Inventor 刘薇薇甘国峰孙克
Owner WUXI JIYU SHANHE PHARM CO LTD
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