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Anthraquinone derivative, preparation method and application thereof

A derivative, anthraquinone technology, applied in the field of anthraquinone derivatives, can solve the problems that have not been seen, obtained anti-porcine reproductive and respiratory syndrome virus, and have no antiviral drugs, so as to inhibit pig reproduction and respiratory Syndrome virus, strong antiviral activity, effect without resource constraints

Active Publication Date: 2012-07-04
OCEAN UNIV OF CHINA
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Problems solved by technology

Due to the particularity of the marine environment and the unique functions of microorganisms in the ecosystem, marine fungi can produce metabolites that terrestrial fungi cannot produce. However, so far, no anti-porcine reproductive and respiratory syndrome virus has been obtained from fungi. (PRRSV) active compound, there is no related antiviral drug on the market

Method used

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  • Anthraquinone derivative, preparation method and application thereof
  • Anthraquinone derivative, preparation method and application thereof
  • Anthraquinone derivative, preparation method and application thereof

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Embodiment Construction

[0009] When preparing the compound of the present invention, the following steps are taken:

[0010] (1) The marine fungus Alternaria sp. (ZJ-2008003) is cultured in the bacterial culture medium. The bacterial culture medium used contains 2.0% glucose (weight percentage, the same below), 20.0% potato, 1.5 agar %, coarse sea salt 3.0%, and the rest is water. When used, it is made into a test tube slope, and the above fungal strains are cultured at 28°C for 5 days.

[0011] Said bacterial culture medium contains glucose 0.1%-5.0% (weight percentage, the same below), potato 5.0%-40.0%, agar 0.1%-3.0%, coarse sea salt 0.05%-5.0%, the rest is water, the culture temperature The temperature is 15-35°C, and the culture time is 3-10 days.

[0012] (2) The fungal strain obtained from the above culture is fermented and cultured, and the fermentation medium used contains 2.0% glucose, 20.0% potato, 3.0% coarse sea salt, and the rest is water. The fungal strain was cultured at 28°C for 30 days....

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Abstract

The invention relates to an anthraquinone derivative, a preparation method and application thereof. During preparation, entomopathogenic fungi in soft coral Alternaria sp. (ZJ-2008003) is first placed in a strain culturing medium for strain culturing and then placed in a fermentation culturing medium for fermentation culturing, obtained fermentation liquor is filtered, thalli are removed to obtain filtrate, and the filtrate is extracted through ethyl acetate; after extract liquor is concentrated, silicagel column chromatography, sephadex LH-20 gel column chromatography and half-preparation of high performance liquid chromatography preparation are conducted, obtained eluent is concentrated, and clear crystals are obtained, namely, the compound of tetrahydroaltersolanols C-E; pink powder is obtained, namely, the compound of tetrahydroaltersolanol F. The anthraquinone derivative originating from marine fungi has strong antiviral effect, can effectively restrain porcine reproductive and respiratory syndrome virus (PRRSV), can be used as antiviral drug, and has broad application prospects due to the fact that raw materials can be produced in a large scale.

Description

Technical field [0001] The invention relates to an anthraquinone derivative extracted and separated from the fermentation broth of marine endophytic fungi, a preparation method thereof and an application as an antiviral drug. Background technique [0002] Since penicillin was prepared from fungi in 1929, fungal metabolites have become a rich source of drugs, and most clinically used antibiotics are derived from fungi and bacteria. The metabolites of fungi have other medicinal values, such as anti-tumor, treatment of cardiovascular diseases, enzyme inhibitors, etc. Due to the particularity of the marine environment and the unique functions of microorganisms in the ecosystem, marine fungi can produce metabolites that terrestrial fungi cannot produce. However, so far, no anti-porcine reproductive and respiratory syndrome virus has been obtained from fungi. (PRRSV) active compounds, there is no related antiviral drugs on the market. Summary of the invention [0003] The purpose of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/747C07C69/21C12P7/26C12P7/62A61K31/122A61K31/222A61P31/12C12R1/645
Inventor 王长云邵长伦郑彩娟
Owner OCEAN UNIV OF CHINA
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