Preparation method of paraffin for pharmaceutic adjuvants

Abstract

The invention discloses a method for refining and deoiling paraffin for pharmaceutic adjuvants, and belongs to the field of medical materials. The method disclosed by the invention comprises the following steps of: refining hydrogenant paraffin which is used as a raw material by adopting an active substance so that the paraffin is effectively deodorized, de-colored and deodorized and the paraffin is odorless and tasteless; 'sweating' the paraffin by using a deoiling box so that the paraffin is deoiled and the oil content of the paraffin is reduced, wherein the active substance is active carbon, diatomite and / or active floridin; and the deoiling box is a device which enable the paraffin to be sweated according to a principle that heating is performed by using different melting points of the paraffin so that oil is separated to be infiltrated to the surface of the paraffin, and the deoiling effect of the deoiling box is that the oil content is reduced from 0.5 percent to 0.3 percent, so that the oil content is effectively reduced and the paraffin is difficult to oxidize. The invention aims to widen the application field of the paraffin, and widen the application field of the paraffin from food industry and daily chemical industry to pharmaceutic adjuvant industry; and the paraffin is mainly used as an ointment base hard-enhancing component and a sustained-release material in medicaments.

Description

technical field [0001] The invention discloses a method for preparing paraffin wax used as a pharmaceutical excipient, belonging to the field of medical materials. Background technique [0002] Paraffin is separated from petroleum crude oil. After the crude oil evaporates gasoline, kerosene, and diesel oil in the atmospheric tower, the remaining part is called waxy distillate oil, which is divided into dewaxed oil (as lubricating oil) by freezing press and solvent dewaxing The main component) and paraffin, which is crude wax for industrial use, but it inevitably contains various impurities, and its use in medicine is bound to cause great harm to human health. details as follows: [0003] 1. Acidity and alkalinity [0004] In the process of industrial wax production, acid and alkali are often used for refining. If the treatment is not good, the residual acid and alkali will cause corrosive damage to human organs. [0005] 2. Oil quality [0006] When separating paraffin w...

AI Technical Summary

Problems solved by technology

[0005] 2. Oil quality

[0006] When separating paraffin wax and microcrystalline paraffin wax from waxy distillate oil or residual oil, depending on the quality of the separation process, more or less residual oil is in the wax. Most of these oils are branched alkanes from the chemical structure. It has no direct impact on human health, but when used in food, it will have adverse effects on the sense of smell, taste and taste

[0007] 3. Biological and debris pollution

[0011] 5. Heavy metals

[0012] Due to the different origins of crude oil, heavy metals contained in some geological structures may also enter the crude oil. During the refining process, catalysts and other additives will also bring some heavy metals, and most of them will enter the residual oil. However, due to poor control of the separation process Or equipment and process reasons, even if a small amount is brought into the wax, such as lead, mercury, cadmium and arsenic residues, it will cause serious harm to the human body