Anti-inflammatory Li nationality medicinal material extract, and its preparation method

Abstract

The invention provides an anti-inflammatory compound extract comprising Li nationality medicinal materials including aerial parts of Ficus pumila L. and Elaeagnus gonyanthes Benth., its preparation method, and a Li nationality medicinal composition containing the active extract. The extract and composition can be used for treating headache, dizziness, rhinorrhea and nasal obstruction due to acute and chronic sinusitis; have no toxic and side effects; and can be prepared into any oral preparation for treating acute and chronic sinusitis.

Description

technical field

[0001] The invention belongs to the field of ethnic medicines, and specifically relates to a Li medicine extract with therapeutic activity for acute and chronic sinusitis, a preparation method thereof, and a Li medicine composition containing the active extract. Background technique

[0002] Ficus pumila L. is a plant of the genus Ficus pumila L. in the family Moraceae, and its aerial part is used as medicine. It is sour in taste and cool in nature; it has the functions of dispelling wind and dampness, promoting blood circulation and dredging collaterals, detoxifying and reducing swelling. Indications for rheumatic arthralgia, sciatica, diarrhea, stranguria, edema, malaria, amenorrhea, postpartum blood stasis abdominal pain, sore throat, orchitis, lacquer sores, painful sores, swollen toxins, traumatic injuries and other diseases.

[0003] Elaeagnus gonyanthes Benth. is a plant of the genus Elaeagnus gonyanthes Benth. in the family Elaeagnus gonyanthes Benth...

Examples

Embodiment 1

[0086] Example 1 The preparation example of the Li medicine mixed extract of the above-ground parts of Fructus Fructus L. and S. chinensis

[0087] After mixing and pulverizing the aerial part of Sapura chinensis and the above-ground part of Scutellaria japonicus at a ratio of 1:1, extract with solvent for 3 times, the amount of solvent added each time is 10-20 times of the amount of medicinal materials, and the extraction time for each time is 3 hours. The extracts are combined and filtered, and the filtrate is concentrated under reduced pressure to obtain a crude extract; the crude extract is subjected to column chromatography with an adsorption resin, and 10-30 times the amount of 0-90% alcohol is used as an eluent for gradient elution, Collect 0-60% eluate, concentrate under reduced pressure and freeze-dry to obtain the Li medicine extract of the present invention.

Embodiment 2

[0088] Embodiment 2 The specific embodiment of preparation of Li medicine composition tablet of the present invention.

[0089] Add 0.5-1 part of starch to 1 part of Li medicine extract obtained in Example 1, mix evenly, granulate, dry, granulate, add magnesium stearate, and compress into tablets to obtain tablets.

Embodiment 3

[0090] Embodiment 3 The preparation of Li medicine composition dispersible tablet of the present invention

[0091] With 1 part of Li medicine extract obtained in Example 1, add 0.5-1 part of starch as a diluent, add 0.5-1 part of microcrystalline cellulose as a disintegrant, and granulate the above mixture (over 20- 12 mesh), drying, adding an appropriate amount of magnesium stearate as a glidant, after mixing evenly, the powder is directly compressed into a tablet to obtain a dispersible tablet.

technical field

[0001] The invention belongs to the field of ethnic medicines, and specifically relates to a Li medicine extract with therapeutic activity for acute and chronic sinusitis, a preparation method thereof, and a Li medicine composition containing the active extract. Background technique

[0002] Ficus pumila L. is a plant of the genus Ficus pumila L. in the family Moraceae, and its aerial part is used as medicine. It is sour in taste and cool in nature; it has the functions of dispelling wind and dampness, promoting blood circulation and dredging collaterals, detoxifying and reducing swelling. Indications for rheumatic arthralgia, sciatica, diarrhea, stranguria, edema, malaria, amenorrhea, postpartum blood stasis abdominal pain, sore throat, orchitis, lacquer sores, painful sores, swollen toxins, traumatic injuries and other diseases.

[0003] Elaeagnus gonyanthes Benth. is a plant of the genus Elaeagnus gonyanthes Benth. in the family Elaeagnus gonyanthes Benth...

Examples

Embodiment 1

[0086] Example 1 The preparation example of the Li medicine mixed extract of the above-ground parts of Fructus Fructus L. and S. chinensis

[0087] After mixing and pulverizing the aerial part of Sapura chinensis and the above-ground part of Scutellaria japonicus at a ratio of 1:1, extract with solvent for 3 times, the amount of solvent added each time is 10-20 times of the amount of medicinal materials, and the extraction time for each time is 3 hours. The extracts are combined and filtered, and the filtrate is concentrated under reduced pressure to obtain a crude extract; the crude extract is subjected to column chromatography with an adsorption resin, and 10-30 times the amount of 0-90% alcohol is used as an eluent for gradient elution, Collect 0-60% eluate, concentrate under reduced pressure and freeze-dry to obtain the Li medicine extract of the present invention.

Embodiment 2

[0088] Embodiment 2 The specific embodiment of preparation of Li medicine composition tablet of the present invention.

[0089] Add 0.5-1 part of starch to 1 part of Li medicine extract obtained in Example 1, mix evenly, granulate, dry, granulate, add magnesium stearate, and compress into tablets to obtain tablets.

Embodiment 3

[0090] Embodiment 3 The preparation of Li medicine composition dispersible tablet of the present invention

[0091] With 1 part of Li medicine extract obtained in Example 1, add 0.5-1 part of starch as a diluent, add 0.5-1 part of microcrystalline cellulose as a disintegrant, and granulate the above mixture (over 20- 12 mesh), drying, adding an appropriate amount of magnesium stearate as a glidant, after mixing evenly, the powder is directly compressed into a tablet to obtain a dispersible tablet.

Images