Solid preparation of bisoprolol / hydrochlorothiazide medicine composition liposome
A technology of hydrochlorothiazide and bisoprolol, applied in the field of medicine, achieves the effects of high encapsulation efficiency, high bioavailability and excellent dissolution
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Embodiment 1
[0090] Example 1 Bisoprolol / Hydrochlorothiazide Liposomal Tablets
[0091]
[0092] Adopt the following production process to prepare bisoprolol / hydrochlorothiazide liposome tablet:
[0093] (1) Accurately weigh 2.5g bisoprolol fumarate, 6.25g hydrochlorothiazide, 80g hydrogenated soybean lecithin, 20g dilauroylphosphatidylcholine, 50g cholesterol, 60g Tween 60, dissolve in 1200ml volume ratio of 2:1 In the mixed solvent of dichloromethane and isopropanol, stir to dissolve it;
[0094] (2) Place the above solution in an eggplant-shaped bottle, remove methylene chloride and isopropanol under reduced pressure in a 45°C water bath, and form a uniform transparent film on the wall of the bottle;
[0095] (3) Add 1200ml of phosphate buffer solution with a pH value of 7.0 to the eggplant-shaped bottle, and continue to rotate in a water bath at 45°C under normal pressure to swell and hydrate the film;
[0096] (4) Filter the above solution with a 0.45 μm microporous membrane, p...
Embodiment 2
[0100] Example 2 Bisoprolol / Hydrochlorothiazide Liposomal Tablets
[0101]
[0102]
[0103] Adopt the following production process to prepare bisoprolol / hydrochlorothiazide liposome tablet:
[0104] (1) Accurately weigh 5g bisoprolol fumarate, 6.25g hydrochlorothiazide, 80g hydrogenated soybean lecithin, 20g dilauroylphosphatidylcholine, 50g cholesterol, 120g Tween 60, dissolve in 1500ml volume ratio of 2:1 In the mixed solvent of dichloromethane and isopropanol, stir to dissolve it;
[0105] (2) Place the above solution in an eggplant-shaped bottle, remove methylene chloride and isopropanol under reduced pressure in a 45°C water bath, and form a uniform transparent film on the wall of the bottle;
[0106] (3) Add 1500ml of phosphate buffer solution with a pH value of 7.0 to the eggplant-shaped bottle, and continue to rotate in a 45°C water bath under normal pressure to swell and hydrate the film;
[0107] (4) Filter the above solution with a 0.45 μm microporous mem...
Embodiment 3
[0111] Example 3 Bisoprolol / Hydrochlorothiazide Liposomal Tablets
[0112] The raw and auxiliary materials used are as follows:
[0113]
[0114]
[0115] Adopt the following production process to prepare bisoprolol / hydrochlorothiazide liposome tablet:
[0116] (1) Accurately weigh 5g bisoprolol fumarate, 6.25g hydrochlorothiazide, 320g hydrogenated soybean lecithin, 80g dilauroylphosphatidylcholine, 200g cholesterol, 120g Tween 60 and dissolve in 2000ml volume ratio of 2:1 In the mixed solvent of methyl chloride and isopropanol, stir to dissolve it;
[0117] (2) Place the above solution in an eggplant-shaped bottle, remove methylene chloride and isopropanol under reduced pressure in a 45°C water bath, and form a uniform transparent film on the wall of the bottle;
[0118] (3) Add 2000ml of phosphate buffer solution with a pH value of 7.0 to the eggplant-shaped bottle, and continue to rotate in a water bath at 45°C under normal pressure to swell and hydrate the film;...
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