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Film-spraying agent for treating acute soft tissue injuries

A soft tissue injury and film-spraying technology, which is applied in the direction of non-central analgesics, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low utilization rate of medicinal materials, easy to stain clothes or slip off , black” and other problems, to improve the effect of acute soft tissue injury, inhibition of increased permeability, and improvement of local microcirculation

Inactive Publication Date: 2012-08-01
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Shuangbai powder is commonly used in two dosage forms: powder and vaseline ointment, both of which have many disadvantages, "thick, large, black", rough production, waste of medicinal materials, poor air permeability, easy to stain clothes or slip off, and even a few patients have Skin allergic reaction etc.; Disclosed in Chinese patent CN1276763C " a kind of compound Chinese medicine composition for the treatment of decubitus, acute soft tissue injury ", it is prepared by rhubarb, arborvitae leaf, Phellodendron Phellodendri, Eupatorium, peppermint 5 taste Chinese medicinal materials, but its The process is cumbersome and the utilization rate of medicinal materials is low. Every 1000ml of liniment needs 286g rhubarb, 286g arborvitae leaves, 143g cork, 143g eupatorium, and 143g mint. The finished product cannot form a film when rubbed on the skin, so the loss is large and the dosage is also large

Method used

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  • Film-spraying agent for treating acute soft tissue injuries
  • Film-spraying agent for treating acute soft tissue injuries
  • Film-spraying agent for treating acute soft tissue injuries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Weigh the following raw materials: 40g of rhubarb, 40g of orientalis leaves, 20g of Cortex Phellodendri, 20g of Eupatorium, 20g of peppermint, 5g of borneol, 1g of menthol; auxiliary materials: 5g of chlorobutanol, 50g of polyvinylpyrrolidone, hydroxypropylmethyl Cellulose 4g,

[0120] Take rhubarb, arborvitae leaves, Phellodendron officinalis, eupatorium, peppermint, add 8 times the amount of 75% ethanol, heat and reflux extract for 1 hour, filter; add 5 times the amount of 75% ethanol solution to the filter residue, heat and reflux extract for 1 hour, filter; Add 5 times the amount of 75% ethanol solution, heat and reflux for extraction for 1 hour, filter; combine the three filtrates, concentrate at 80°C to a relative density of 0.920 (50°C heat test), add polyvinylpyrrolidone, hydroxypropyl methylcellulose, mix Evenly, let stand, pour out the supernatant, and set aside; Dissolve borneol, menthol and chlorobutanol in 20ml of 95% ethanol, add to the supernatant, stir w...

Embodiment 2

[0124] Weigh the following raw materials: 20g of rhubarb, 20g of orientalis leaves, 10g of Phellodendron arborvitae, 10g of Eupatorium, 10g of mint, 2g of borneol, 0.4g of menthol; auxiliary materials: 2g of chlorobutanol, 30g of polyvinylpyrrolidone, hydroxypropyl methyl Base cellulose 1g,

[0125] Take rhubarb, arborvitae leaves, Phellodendron officinalis, eupatorium, peppermint, add 8 times the amount of 75% ethanol, heat and reflux extract for 1 hour, filter; add 5 times the amount of 75% ethanol solution to the filter residue, heat and reflux extract for 1 hour, filter; Add 5 times the amount of 75% ethanol solution, heat and reflux for extraction for 1 hour, filter; combine the three filtrates, concentrate at 80°C to a relative density of 0.920 (50°C heat test), add polyvinylpyrrolidone, hydroxypropyl methylcellulose, mix Evenly, let stand, pour out the supernatant, and set aside; Dissolve borneol, menthol and chlorobutanol in 20ml of 95% ethanol, add to the supernatant,...

Embodiment 3

[0129] Weigh the following raw materials: 60g of rhubarb, 60g of arborvitae leaves, 30g of Phellodendron arborvitae, 30g of Eupatorium, 30g of mint, 6g of borneol, 1.2g of menthol; auxiliary materials: 6g of chlorobutanol, 60g of polyvinylpyrrolidone, hydroxypropyl methyl Base cellulose 8g,

[0130] Take rhubarb, arborvitae leaves, Phellodendron officinalis, eupatorium, peppermint, add 8 times the amount of 75% ethanol, heat and reflux extract for 1 hour, filter; add 5 times the amount of 75% ethanol solution to the filter residue, heat and reflux extract for 1 hour, filter; Add 5 times the amount of 75% ethanol solution, heat and reflux for extraction for 1 hour, filter; combine the three filtrates, concentrate at 80°C to a relative density of 0.920 (50°C heat test), add polyvinylpyrrolidone, hydroxypropyl methylcellulose, mix Evenly, let stand, pour out the supernatant, and set aside; Dissolve borneol, menthol and chlorobutanol in 20ml of 95% ethanol, add to the supernatant,...

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Abstract

The invention relates to an external preparation made from Chinese herbal medicines, specifically to a film-spraying agent for treating acute soft tissue injuries. 1000ml of the film-spraying agent in the invention is composed of the following raw materials: a Chinese herbal extract extracted from 20-60g of rheum officinale, 20-60g of Cacumen Platycladi, 10-30g of Cortex Phellodendri amurensis, 10-30g of Herba Lycopi and 10-30g of mint by ethanol, 2-6g of borneol, 0.4-1.2g of menthol, 2-6g of chlorobutanol, 30-60g of polyvinylpyrrolidone, 1-8g of hydroxypropyl methyl cellulose, and the rest ethanol water with a volume concentration of 30-40%. During application, the film-spraying agent of the invention is directly sprayed on the injured part and can form a film in 8 minutes. With good anti-inflammation, pain easing, stasis removing, acute soft tissue injury improving and microcirculation improving, as well as antibacterium effects, the film-spraying agent provided in the invention has an obvious effect in treating acute soft tissue injuries such as sprains, contusions and other local injuries, and redness, swelling, heat, pain, wound surface infection, as well as other aspects.

Description

technical field [0001] The invention relates to an external preparation made of Chinese medicinal materials, in particular to a film-spraying agent for treating acute soft tissue injury. [0002] Background technique [0003] Shuangbai powder is widely used in surgery, orthopedics and traumatology by Guangzhou University of Traditional Chinese Medicine. It is composed of five medicinal materials: rhubarb, arborvitae, cork, euphemum, and mint. The effect. More than 40 years of clinical practice have shown that it has significant curative effects on soft tissue injuries, fractures, sores, and swelling. In addition, it is also used for acute appendicitis, pelvic inflammatory disease, and pleurisy. As early as 1964, Shuangbaisan was included in the trial textbook "Lecture Notes on Traumatology of Traditional Chinese Medicine" of the College of Traditional Chinese Medicine, and it was promoted and used throughout the country. Later, it was included in the textbooks "Chinese Me...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/08A61K47/38A61P29/00A61K31/045
Inventor 魏刚刘东辉黄月纯何坦朱小凤欧阳伟珊陈国留刘翠玲
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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