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Device for cultivating cells and/or microorganisms

A reactor and container technology, applied in the field of reactors, can solve problems such as insufficient gas supply for cells and/or microorganisms

Inactive Publication Date: 2012-08-22
BAYER IP GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] When the gas is introduced into the reactor only by surface aeration, there is a risk of insufficient gas supply to the cells and / or microorganisms through the reduced surface-to-volume ratio with increasing reactor size, especially in larger reactors

Method used

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  • Device for cultivating cells and/or microorganisms
  • Device for cultivating cells and/or microorganisms
  • Device for cultivating cells and/or microorganisms

Examples

Experimental program
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Embodiment Construction

[0108] figure 1 A preferred embodiment of the container 1 according to the invention is shown schematically in a perspective view from the front (a) and obliquely from above (b). The container has a base 20 that is arched pyramidally into an interior 40 . The vessel has an interior space 40 for accommodating the reactor and lateral channels 30 for guiding connecting lines.

[0109] figure 2 (a) shows the cross-section from above figure 1 in the container. figure 2 (b) along the figure 2 The container 1 is shown in cross-section between points A and B with dashed lines shown in (a).

[0110] image 3 (a) shows a preferred embodiment of the container 1 according to the invention in a perspective view. A web 50 is arranged in the region of the container bottom. The area of ​​the container 1 comprising the gusset 50 is at image 3 It is shown enlarged in (b). In the embodiment shown, the connecting plate 50 includes a connecting point 52 which is connected to the re...

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Abstract

The invention relates to a reactor designed as a disposable element, a container for receiving the reactor, a device comprising a reactor, and a drive unit for generating a rotating-oscillating motion of the reactor, and the use of the device for cultivating cells and / or microorganisms.

Description

technical field [0001] The object of the invention is a reactor preferably embodied as a disposable element, a container for accommodating the reactor, a device comprising the reactor and a drive unit for generating a rotational vibratory movement of the reactor, and for culturing cells and / or microorganisms use of the device. Background technique [0002] In highly controlled (regulieren) pharmaceutical production processes, considerable time, technical and personnel expenditure falls on providing clean and sterile bioreactors. In order to reliably avoid cross-contamination in multi-purpose plants or in the event of product changes between two product batches (Produktcharge), in addition to the cleaning unit, a very complex cleaning validation (Reinigungsvalidierung) is required, which is included in the process adaptation (Prozessadaption) should be repeated if possible. [0003] This applies not only to Upstream-Processing USP, ie the production of biological products i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/28C12M1/00B01J15/00B01F11/00
CPCB01J19/285C12M23/26C12M27/10G06K19/0716B01F31/10B01F35/53B01J19/28C12M1/00B01J15/00B01F31/00
Inventor J·考林B·莫伊泽A·布劳恩S·肖森W·卡勒特
Owner BAYER IP GMBH
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