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Digital adjustable microinjection method

A syringe and adjustable technology, applied in the field of syringes, can solve the problems of large tissue damage, blockage of syringe needles, and increase the operational complexity of traditional micro-injection methods, and achieve the effects of convenient injection volume and convenient control.

Inactive Publication Date: 2015-01-07
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional micro-injection is carried out by pushing the piston of the micro-injection syringe with one hand, the injection speed cannot be kept constant, the tissue damage is large, and the interpretation of the experimental results is affected; the syringe needle is often blocked, which affects the experimental process, and the operation accuracy cannot meet the above requirements
Some reagents require voltage iontophoresis, which increases the operational complexity of traditional microinjection methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Such as figure 1 As shown, a digital adjustable micro-injection method at least includes a tube body, the tube body is composed of a piston tube body 1 and a syringe tube body 20, the lower end of the syringe tube body 20 is the syringe liquid outlet 4, and the piston chamber of the piston tube body 1 The chamber 14 is divided into an upper chamber 16 and a lower chamber 17 by a piston 18, and the upper chamber 16 and the lower chamber 17 have an air input / output port 11 and an air output / input port 12 respectively. The gas input / output port 11 can be the gas input port or the gas output port; similarly, the gas output / input port 12 can be the gas output port or the gas input port; the lower end of the syringe piston 2 extends into the syringe tube The injection chamber 3 of the body 20, the injection chamber 3 sucks the injection through the syringe outlet 4; the upper chamber 16 has a pressure sensor interface, and the pressure sensor 7 is connected through the pressu...

Embodiment 2

[0021] Such as image 3 As shown, a digitally adjustable micro-injector at least includes a tube body, the tube body is composed of a piston tube body 1 and a syringe tube body 20, the piston tube body 1 and the syringe tube body 20 are an integrated tube body structure, and the tube body is composed of a sealing port 13 is divided into a piston chamber 14 and an injection chamber 15, the lower end of the injection chamber 15 is the syringe outlet 4, the piston chamber 14 is divided into an upper chamber 16 and a lower chamber 17 by a piston 18, and the upper chamber 16 and the lower chamber The cavity 17 has an air input / output port 11 and an air output / input port 12 respectively. The gas input / output port 11 can be the gas input port or the gas output port; similarly, the gas output / input port 12 can be the gas output port or the gas input port; the injection chamber 15 has Syringe piston 2, the injection liquid chamber 3 is formed at the lower end of the syringe piston 2, ...

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Abstract

The invention relates to a digital adjustable microinjection method. An injector at least comprises a pipe body, wherein the pipe body consists of a piston pipe body and an injector pipe body; an injector liquid outlet is arranged at the lower end of the injector pipe body; the piston cavity of the piston pipe body is divided into an upper cavity and a lower cavity through a piston; the upper cavity and the lower cavity are provided with a gas inlet / outlet and a gas outlet / inlet respectively; the lower end of the injector piston stretches into an injection chamber of the injector pipe body; the injection chamber sucks in injection through the injector liquid outlet; the upper cavity is provided with a pressure sensor interface and is connected with a pressure sensor through the pressure sensor interface; the lower cavity is provided with a displacement sensor interface and is connected with a displacement sensor through the displacement sensor interface; the gas inlet / outlet and the gas outlet / inlet are connected with a proportional reversing valve; and the proportional reversing valve is connected with a gas pump and a gas source. The digital adjustable microinjection method has the characteristics of being a stereotactic micro-delivery system which is small in tissue injury, convenient and quick in use and high in reproducibility; and the injection device integrates mechanical injection and voltage iontophoresis.

Description

technical field [0001] The invention relates to a syringe, in particular to a digitally adjustable micro-injection method, which is used to control the amount of liquid entering a laboratory. Background technique [0002] Research in neuroscience is in the ascendant. Stereotaxic drug administration to animal brains is a frequently used experimental method in neuroscience research. Such as brain nuclei localized injection of beam tracers, active drugs, receptor agonists, receptor antagonists, etc. This micromanipulation requires precise injection volume (0.1 microliter), constant injection speed, good repeatability, and minimal tissue damage. Traditional microinjection is carried out by pushing the plunger of the microsyringe with one hand. The injection speed cannot be kept constant, and the tissue damage is large, which affects the interpretation of the experimental results. Moreover, the syringe needle is often blocked, which affects the experimental process, and the ope...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D7/00A61M5/20
Inventor 朱超孙莉莉王文高昌俊每晓鹏陈磊董玉琳李辉武胜昔李云庆
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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