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Sodium pyruvate nasal spray and preparation method thereof

A technology of sodium pyruvate and nasal spray, applied in the medical field, can solve the problems of difficulty in air selection, increase in acute and chronic rhinitis, allergic rhinitis, colds, nasal mucosa damage, etc., to achieve the effect of increasing flushing, improving residence time, optimizing effect of prescription

Active Publication Date: 2012-09-12
JIANG SU PHARMAMAXCORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] People have choices about the drinking water they need every day, but it is difficult to choose the air they need, especially dust, viruses, bacteria and mold-causing pollution sources in the air, etc., have no choice, often accompanied by respiratory transmission and infection, which greatly Increased the incidence of acute and chronic rhinitis, allergic rhinitis, colds, and respiratory diseases, causing great damage to the nasal mucosa

Method used

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  • Sodium pyruvate nasal spray and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Name of raw material Dosage (grams) Proportion(%) sodium pyruvate 22 0.22 Pyruvate 5 0.05 Sodium chloride 45 0.45 Benzalkonium chloride 1 0.01

[0017] Preparation Process:

[0018] Slowly add the prescribed amount of sodium pyruvate, pyruvic acid, and sodium chloride into 9500 grams of purified water, heat to 40-50°C and stir to dissolve, then cool down to 25-35°C, add the prescribed amount of benzalkonium chloride, and stir evenly. Use 0.1mol / l sodium hydroxide to adjust the pH of the solution to 6, then use the remaining water to make up to 10,000 grams, filter and fill. The preparation contains 0.22% sodium pyruvate and 0.05% pyruvate, and is mainly used to clean the environment in the nasal cavity.

Embodiment 2

[0020] Name of raw material Dosage (grams) Proportion(%) sodium pyruvate 22 0.22 Pyruvate 5 0.05 potassium chloride 45 0.45 Benzalkonium chloride 3 0.03

[0021] Preparation Process:

[0022] Slowly add the prescribed amount of sodium pyruvate, pyruvic acid, and potassium chloride to 9500 grams of purified water, heat to 40-50°C and fully stir to dissolve, cool down to 25-35°C, add the prescribed amount of benzalkonium chloride, and stir evenly. Use 0.1mol / l hydrochloric acid to adjust the pH of the solution to 5.5, then use the remaining water to make up to 10,000 grams of the total volume, filter, and fill it. The preparation contains 0.22% sodium pyruvate and 0.05% pyruvate, and is mainly used to clean the environment in the nasal cavity.

Embodiment 3

[0024] Name of raw material Dosage (grams) Proportion(%) sodium pyruvate 16 0.16 Pyruvate 11 0.11 glucose 30 0.3 Benzalkonium chloride 25 0.25

[0025] Preparation Process:

[0026] Slowly add the prescribed amount of sodium pyruvate, pyruvate, and glucose into 9500 g of purified water, heat to 40-50°C and fully stir to dissolve, cool down to 25-35°C, add benzalkonium chloride, stir evenly, and use 0.1mol / l hydrochloric acid to adjust the pH of the solution to 4.5, then use the remaining water to make up the volume to 10,000 grams, filter, and fill. The preparation contains 0.16% sodium pyruvate and 0.03% pyruvate, and is mainly used to clean the environment in the nasal cavity.

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Abstract

The present invention relates to a nasal spray containing sodium pyruvate and a preparation method thereof, belonging to the field of medical technology, being characterized in that: the nasal spray containing sodium pyruvate comprises the following components: sodium pyruvate, pyruvic acid, an isoosmotic adjusting agent, a preservative and water. Because the sodium pyruvate is capable of alleviating nasal obstruction and inflammation caused by rhinitis, a medical fluid provided in the invention can be made into a nasal spray medical fluid which is capable of entering nasal cavities by adopting a portable spraying device. The nasal spray medical fluid is particularly suitable for cleaning and removing harmful pollutants in nasal passages, paranasal sinuses and mucosal cilia and is capable of being used in nursing after a nasal cavity operation, relieving rhinostegnosis and reducing respiratory tract irritation and risks of infection. By adding the pyruvic acid to form a buffer solution, tingling caused by using the flushing fluid to wash the cavities can be reduced, and inflammation is alleviated. Allergic symptoms can be prevented or gradually alleviated for the people of special professional who often use the product provided in the invention to wash and care nasal cavities.

Description

technical field [0001] The invention relates to a nasal spray containing sodium pyruvate and a preparation method thereof, belonging to the field of medical technology. Background technique [0002] Breathing is the foundation of life. Breathing is completed by the upper respiratory tract and the lower respiratory tract. The nasal cavity, nasal sinuses and nasopharynx are the main components of the upper respiratory tract, and are the necessary places for the human body to exchange materials with nature. Sodium pyruvate is a normal component of all human and animal bodies, and is the basic metabolism of organisms. Sodium pyruvate has a significant protective effect on multi-cell and multi-organ functions, especially for important organs: heart, liver, brain and kidney. Blood / reperfusion injury is repaired without toxic side effects. [0003] People have choices about the drinking water they need every day, but it is difficult to choose the air they need, especially dust, vi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/19A61K47/12A61P11/02
Inventor 蒋志君阿兰·马丁曹家祥黄小棠
Owner JIANG SU PHARMAMAXCORP
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