Propranolol-eugenol type basil oil nano-emulsion medicament and preparation method thereof

A technology of clove basil oil and nanoemulsion, which is applied in the field of medicine, can solve the problems that propranolol and clove basil oil cannot be used, the action of propranolol is slow, and the dissolution rate of the drug is slow, so as to maintain blood drug Concentration and pharmacological effects, reducing first-pass effects, and improving bioavailability
CN102657697AInactive Publication Date: 2012-09-12NORTHWEST A & F UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHWEST A & F UNIV
Publication Date
2012-09-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a propranolol-eugenol type basil oil nano-emulsion medicament, which consists of the following raw materials in percentage by mass: 1-10 percent of propranolol, 10-30 percent of surfactant, 0-25 percent of cosurfactant, 1-15 percent of eugenol type basil oil and the balance of distilled water, wherein the mass percentage sum of the raw materials is 100 percent. A nano-emulsion has the characteristics of small emulsion drop particles, uniform distribution, low viscosity and high flowability. In a nano-emulsion dosage form, propranolol serving as a water-soluble medicament is organically combined with fat-soluble eugenol type basil oil, so that the dissolving and permeation capabilities of eugenol type basil oil are increased, and the stability and medicament effect of propranolol are enhanced. After the propranolol and the eugenol type basil oil are prepared into a nano-emulsion dosage form, the advantages of the propranolol and the eugenol type basil oil are combined, the hypertension resisting effect is enhanced remarkably, the half-life period of a medicament is prolonged, and the administration times are reduced.
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Description

technical field

[0001] The invention belongs to the field of medicine and relates to a new dosage form of antihypertensive medicine propranolol and clove basil oil, in particular to a propranolol and clove basil oil nanoemulsion medicine and a preparation method thereof. Background technique

[0002] Propranolol. Chemical name: 1-isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride. Its levorotatory activity is stronger than that of dextrorotatory. Its racemate is used clinically. This product is the earliest beta-receptor blocker used in clinical practice. After oral administration, it can be quickly and completely absorbed in the gastrointestinal tract, but the clearance rate in the liver is very high, and only about 30% enter the blood circulation. The drug concentration in plasma varies greatly, so there are significant individual differences in clinical dosage. It is mainly metabolized in the liver, and most of it is excreted by the kidneys.

[0003] Competes...

Claims

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