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Systems and methods for improving motor function with assisted exercise

A technology of motor function and exercise, applied in sports accessories, passive exercise equipment, physical therapy, etc., can solve the problems of small drug effect and weakening the ability of patients to exercise

Active Publication Date: 2012-09-26
THE CLEVELAND CLINIC FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, in the later stages of certain neurological disorders, including PD, medications are less effective, thus further impairing the patient's ability to exercise

Method used

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  • Systems and methods for improving motor function with assisted exercise
  • Systems and methods for improving motor function with assisted exercise
  • Systems and methods for improving motor function with assisted exercise

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Ten patients (8 men and 2 women; age 61.2±6.0 years, Table 1) with idiopathic PD were randomly assigned to complete an 8-week forced exercise (FE) or voluntary (VE) intervention. After the 8-week intervention, patients were instructed to return to their pre-enrollment activity levels; compliance with this requirement was tracked for patient return instructions. Patients in the FE group exercised on a stationary cascaded bicycle with the training machine ( Figure 4 a), however the VE group (Schoberer Rad Me βtechnik (SRM)) was exercised on a stationary single bicycle. The work performed by the patient and the trainer on the cascade bicycle was measured independently with 2 commercially available power meters (SRM PowerMeter; Jülich, Germany).

[0081] Table 1

[0082] group statistics a

[0083]

[0084] Abbreviations: bpm, heartbeat per minute; EOT, end of training; EOT+4, 4 weeks after EOT; kJ, kilojoules; PD, Parkinson's disease; rpm, revolutions per minute; U...

Embodiment 2

[0112] Using an MRI protocol including whole-brain MPGR anatomical images, diffuse tensor muscle imaging, and functional MRI (fMRI), the effects of vigorous compulsive exercise on brain activation patterns were investigated in six patients with mild to moderate PD. For all scanning sessions, patients were "off" anti-Parkinsonian medications. Patients were scanned under two conditions, no exercise and after forced exercise. The order of these scans was randomized among the six patients and the scans were separated by 5-7 days. Over two days, patients reported to the laboratory at approximately 9 am and completed UPDRS and biomechanical testing, and completed a familiarization test with a motor task to be performed within the scanner. On forced exercise days, patients performed 40 minutes of forced exercise (same as demonstrated in Example 1) and were clinically assessed with UPDRS, blinded assessment. After completing these activities, the patient rested and was offered a sna...

Embodiment 3

[0120] In a situation similar to that described in Example 2, mean fMRI data from ten patients in three different groups (drug off, on drug, and off drug and underwent forced exercise) were obtained at Figure 9 shown in . This fMRI data demonstrates activation of supplementary motor areas of the cortex (top image) and basal ganglia (bottom image) after forced exercise.

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Abstract

One embodiment of the present invention includes a system and method for alleviating symptoms of a medical disorder of a patient by forced exercise. The system includes an exercise machine having movable portions that move in response to a first contribution by a patient and in response a second contribution by a motor. The system further includes at least one mechanical sensor and a control system programmed to alter the second contribution by the motor in response to the sensed data.

Description

[0001] Statement Regarding Federally Sponsored Research or Development [0002] This invention was made with government support under Grant No.: R21 HD056316 from the National Institutes of Health and the National Institute of Neurological Disorders and Stroke. The United States Government has certain rights in this invention. [0003] References to related applications [0004] This application claims priority to U.S. Provisional Application No. 61 / 248,515, filed October 5, 2009, and U.S. Application No. 12 / 635,220, filed December 10, 2010, the entire contents of which are incorporated herein by reference middle. technical field [0005] The present invention generally relates to systems and methods for medical treatment. In particular embodiments, the present invention relates to systems and methods for improving motor function in patients suffering from neurological disorders. Background technique [0006] Neurological disorders, including those neuromotor and neuroco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61H1/02A63B24/00
Inventor 杰伊・L・艾伯茨
Owner THE CLEVELAND CLINIC FOUND
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