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Method for preparing chewable tablets of drug for treating unstable angina pectoris

A technology for instability and angina pectoris, applied in the field of drug chewable tablet preparation, can solve the problems of cumbersome inconvenience and difficulty for patients to adhere to, and achieve the effect of convenient dosage form, convenient taking, and reduced volume

Inactive Publication Date: 2014-02-19
TANGSHAN VOCATIONAL & TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the course of treatment is 4 weeks, and the decoction form is taken continuously for 28 days, which is cumbersome and inconvenient, and it is difficult for patients to persist

Method used

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  • Method for preparing chewable tablets of drug for treating unstable angina pectoris
  • Method for preparing chewable tablets of drug for treating unstable angina pectoris

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1, the weight ratio of raw materials: 10 parts of cassia twig, 6 parts of Codonopsis radix, 3 parts of aconite, 6 parts of astragalus, 3 parts of kudzu root, 6 parts of salvia miltiorrhiza, 3 parts of longan, 15 parts of Jiangxiang, 15 parts of mussels, 6 parts of Galangal, 5 parts of Crab Seven, 6 parts of Corydalis Corydalis, 6 parts of Chishi Zhi, 3 parts of Huoxue Pill, 1 part of Dried Blood. It can be prepared as follows:

[0036] (1) Extract the volatile oil from the coarse powder of cassia twig, longum longum, jiangxiang, and galangal by steam distillation, and collect the dregs for later use;

[0037] (2) Wash pueraria root, mussels, and crab powder, add 2 times the water to decoct, keep stirring, gradually concentrate, dry, crush the mature powder, and pass through an 80-mesh sieve;

[0038] (3) Pulverize dried blood and pass through a 150-mesh sieve to obtain a fine powder for later use;

[0039] (4) Mix the dregs obtained in step 1 with Codonopsis p...

Embodiment 2

[0042] Example 2, raw material drug weight ratio: 20 parts of cassia twig, 10 parts of Codonopsis radix, 6 parts of aconite, 10 parts of astragalus, 6 parts of kudzu root, 10 parts of salvia miltiorrhiza, 6 parts of longan, 20 parts of Jiangxiang, 20 parts of mussels, 12 parts of Galangal, 6 parts of Crab Seven, 10 parts of Corydalis Corydalis, 10 parts of Chishi Zhi, 6 parts of Huoxue Pill, 2 parts of Blood Dragon. It can be prepared as follows:

[0043] (1) Extract the volatile oil from the coarse powder of cassia twig, longum longum, jiangxiang, and galangal by steam distillation, and collect the dregs for later use;

[0044] (2) Wash pueraria root, mussels, and crab powder, add 2 times the water to decoct, keep stirring, gradually concentrate, dry, crush the mature powder, and pass through a 100-mesh sieve;

[0045] (3) Crush dried blood and pass through a 200-mesh sieve to obtain a fine powder for later use;

[0046] (4) Mix the dregs obtained in step 1 with Codonopsis ...

Embodiment 3

[0049] Example 3, the weight ratio of raw materials: 30 parts of cassia twig, 12 parts of Codonopsis radix, 10 parts of aconite, 12 parts of astragalus, 10 parts of kudzu root, 12 parts of salvia miltiorrhiza, 10 parts of Piper longum, 30 parts of Jiangxiang, 30 parts of mussels, 15 parts of Galangal, 9 parts of Crab Seven, 12 parts of Corydalis Corydalis, 12 parts of Chishi Zhi, 9 parts of Huoxue Pill, and 3 parts of Dried Blood. It can be prepared as follows:

[0050] (1) Extract the volatile oil from the coarse powder of cassia twig, longum longum, jiangxiang, and galangal by steam distillation, and collect the dregs for later use;

[0051] (2) Wash pueraria root, mussels, and crab powder, add 2 times the water to decoct, keep stirring, gradually concentrate, dry, crush the mature powder, and pass through a 150-mesh sieve;

[0052] (3) Pulverize dried blood and pass through a 150-mesh sieve to obtain a fine powder for later use;

[0053] (4) Mix the dregs obtained in step...

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Abstract

The invention discloses a method for preparing chewable tablets of a drug for treating unstable angina pectoris, and aims to solve the problem of treatment of unstable angina pectoris. The preparation method is characterized by comprising the steps as follows: (1), cassia twigs, long pepper, dalbergia wood and coarse galangal powder are subjected to steam distillation for extracting volatile oil for standby; (2), kudzuvine root, edible mussel and arisaema fargesii are decocted, condensed, dried and crushed to obtain cooked powder; (3), sanguis draconis is crushed to obtain fine powder for standby; (4), medicinal residue obtained in step 1 is mixed and decocted with radix codonopsitis, milk vetch, radix aconite lateralis preparata, radix salviae miltiorrhizae, corydalis tuber, red halloysite and glechoma longituba, the decoction solution is filtered and condensed to thick extractum, and the thick extractum is dried and crushed to obtain dry extractum powder; (5), the dry extractum powder, the cooked powder and the volatile oil are mixed uniformly, granulated and stabilized to obtain dry granules; and (6), the dry granules are added in the fine powder obtained in step 3, mixed uniformly and compressed into tablets. Clinical trial proves that the chewable tablets prepared with the method provided by the invention have the characteristics of good curative effect and high safety when being used for treating unstable angina pectoris, thereby being worthy of clinical application and popularization.

Description

【Technical field】 [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of a chewable tablet of medicine for treating unstable angina pectoris. 【Background technique】 [0002] Unstable angina (UA) is a clinical manifestation between exertional stable angina and acute myocardial infarction. It mainly includes initial angina pectoris, worsening exertional angina pectoris, rest angina pectoris with ischemic changes in ECG, and early angina pectoris after myocardial infarction. It is characterized by a progressive increase in angina symptoms, new onset of resting or nocturnal angina or prolonged angina. Compared with stable angina, pain in unstable angina is more intense, lasts longer, can be induced by lower levels of activity, can occur spontaneously at rest (supine angina), and is progressive (exacerbating) in nature , these changes can be combined arbitrarily. UA is usually the precursor of acute myocardial infarc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61P9/10A61K33/26A61K35/56A61K35/618
Inventor 杨殿福徐泊文温丽雅刘士生刘雅馨冯晓昕刘志凤姜淑凤
Owner TANGSHAN VOCATIONAL & TECHN COLLEGE
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