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Method for preparing pH-sensitive photocrosslinkable hydrogel

A technology of cross-linked hydrogel and photo-cross-linking agent, which is applied in the field of preparation of pH-sensitive photo-cross-linked hydrogel, can solve the problem that glutaraldehyde and carboxymethyl chitosan aqueous solution are difficult to mix uniformly and gel Weak pH sensitivity or even no problems, to achieve the effect of being suitable for industrial production, convenient dosage form molding, and increasing water solubility

Inactive Publication Date: 2011-02-09
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are two defects in this method: one, because the cross-linking reaction of glutaraldehyde and the amino groups on chitosan is extremely rapid, it is difficult to mix homogeneously with glutaraldehyde and carboxymethyl chitosan aqueous solution.
However, the gel synthesized by this photocrosslinking method has only weak pH sensitivity, because the amino group on chitosan, which determines the pH sensitivity of the gel, is esterified, making the pH sensitivity of the gel very weak or even non-existent.

Method used

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  • Method for preparing pH-sensitive photocrosslinkable hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Dissolve 0.4 g of the synthesized 4-azidobenzaldehyde in 0.1 g of absolute ethanol to prepare a photocrosslinking agent solution with a weight concentration of 80%, and store it away from light. The carboxymethyl substitution degree is 0.8, the viscosity average molecular weight is 5.5×10 5 Add 0.15 g of carboxymethyl chitosan into 15 g of distilled water, stir at room temperature until completely dissolved, and obtain a carboxymethyl chitosan aqueous solution with a weight concentration of 1%. Under the condition of protecting from light, 0.03 g of the above-mentioned photocrosslinking agent solution was added dropwise to the obtained carboxymethyl chitosan aqueous solution, and then the temperature was controlled at 25° C. and the reaction was stirred in the dark to make it completely mixed evenly. After vacuum degassing, spread the reaction solution on a glass plate, and irradiate with ultraviolet light (20w, 253.7nm) to form a pH-sensitive hydrogel.

Embodiment 2

[0023] Dissolve 0.4 g of the synthesized 4-azidobenzaldehyde in 0.1 g of absolute ethanol to prepare a photocrosslinking agent solution with a weight concentration of 80%, and store it away from light. The carboxymethyl substitution degree is 1.0, the viscosity average molecular weight is 5.5×10 5 Add 0.15 g of carboxymethyl chitosan into 7.5 g of distilled water, stir at room temperature until completely dissolved, and obtain a carboxymethyl chitosan aqueous solution with a weight concentration of 2%. Under the condition of protecting from light, 0.03 g of the above-mentioned photocrosslinking agent solution was added dropwise to the obtained carboxymethyl chitosan aqueous solution, and then the temperature was controlled at 25° C. and the reaction was stirred in the dark to make it completely mixed evenly. After vacuum degassing, spread the reaction solution on a glass plate, and irradiate with ultraviolet light (20w, 253.7nm) to form a pH-sensitive hydrogel.

Embodiment 3

[0025] Dissolve 0.4 g of the synthesized 4-azidobenzaldehyde in 0.1 g of absolute ethanol to prepare a photocrosslinking agent solution with a weight concentration of 80%, and store it away from light. The carboxymethyl substitution degree is 1.2, the viscosity average molecular weight is 5.5×10 5 Add 0.15 g of carboxymethyl chitosan into 5 g of distilled water, stir at room temperature until completely dissolved, and obtain a carboxymethyl chitosan aqueous solution with a weight concentration of 3%. Under the condition of protecting from light, 0.03 g of the above-mentioned photocrosslinking agent solution was added dropwise to the obtained carboxymethyl chitosan aqueous solution, and then the temperature was controlled at 25° C. and the reaction was stirred in the dark to make it completely mixed evenly. After vacuum degassing, spread the reaction solution on a glass plate, and irradiate with ultraviolet light (20w, 253.7nm) to form a pH-sensitive hydrogel.

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Abstract

The invention relates to a method for preparing pH sensitive photo-crosslinking hydrogel, comprising the steps as follows: dissolving 4-nitrine benzaldehyde in organic solution to be prepared into photo-crosslinking agent solution; stirring and mixing evenly carboxymethyl chitosan aqueous solution with weight concentration of 0.5-10% and photo-crosslinking agent solution following the weight ratio of 100:0.1-0.8 at 30 DEG C or below while keeping out of the sun; simultaneously reacting to generate photo-crosslinking carboxymethyl chitosan giant molecule aqueous solution; then, carrying out vacuum defoamation on the carboxymethyl chitosan giant molecule aqueous solution and tiling the aqueous solution on a glass sheet or injecting the aqueous solution in a mould; carrying out ultraviolet light irradiation to trigger cross linking reaction, thus obtaining the hydrogel: the method of the invention not only solves the problems that glutaric dialdehyde has much too fast reaction velocity as cross linking agent, the solution is not mixed evenly prior to cross linking and bubbles are numerous; in addition, in the preparation process, drug loading in situ can be realized, thus facilitating forming of preparation formulation; the hydrogel prepared by the method of the invention not only features an even structure but also relatively good pH sensitivity, thus making a sustained release carrier of medicine.

Description

technical field [0001] The invention relates to a gel material, in particular to a preparation method of a pH-sensitive photocrosslinked hydrogel. Background technique [0002] pH-sensitive hydrogels are polymer hydrogels containing ionizable acidic or basic groups (carboxyl, sulfonic acid or amino groups) in the network structure, and these groups will ionize as the pH value of the medium changes. , resulting in different ionization strengths, leading to changes in the network structure and charge density, resulting in discontinuous swelling volume changes. Utilizing this property of the pH-sensitive hydrogel, it can be used as a drug carrier to conveniently adjust and control the diffusion and release rate of the drug in the gel, and realize the controlled release of the drug. [0003] Carboxymethyl chitosan (CMCS), a derivative of chitosan, is an amphoteric polyelectrolyte with water solubility, good biocompatibility and biodegradability, and is widely used in pharmaceut...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/16A61K9/00A61K47/36
Inventor 殷以华吕祥兰徐莎郑化
Owner WUHAN UNIV OF TECH
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