Composite acne removing lipid nanoparticle emulsion and preparation method thereof
A lipid nanoparticle and nanoparticle technology, which is used in drug combinations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of inconvenience, large odor, and difficulty in entering the deep layers of the skin, and achieves inhibition of acne bacillus, peculiar smell, etc. Small, improve the effect of acne
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Embodiment 1
[0020] A preparation method of compound acne-removing lipid nanoparticle emulsion, comprising the steps of:
[0021] A. Take by weighing 1.2g Vitex paniculata extract, 1.2g Centella asiatica extract, 0.6g tetrahydropiperine to form a composite acne-removing active substance;
[0022] B. Weigh 0.5g poloxamer 188, 0.5g poloxamer 407, 5.0g polyglycerol-10 myristate, 30.0g monoglyceride stearate, and carry out the compound anti-acne active substance obtained in step A Mix, then heat to 75°C, and stir with a propeller stirrer at a speed of 600 rpm for 10 minutes to obtain a liquid oil phase;
[0023] C. Weigh 61.0 g of distilled water at 85° C., mix the distilled water with the liquid oil obtained in step B to obtain a mixed solution, and stir the mixed solution evenly with a propeller stirrer at a speed of 600 rpm;
[0024] D. Pour the mixed solution obtained in step C into a high-pressure homogenizer for emulsification, control the pressure at 70 MPa, and the temperature at 85° ...
Embodiment 2
[0033] A preparation method of compound acne-removing lipid nanoparticle emulsion, comprising the steps of:
[0034] A. Weigh 1.0g Vitex paniculata extract, 1.6g Centella asiatica extract, 0.1g tetrahydropiperine to form a compound acne-removing active substance;
[0035] B. Weigh 0.25g poloxamer 188, 0.25g poloxamer 407, 1.0g polyglycerol-10 myristate, 3.0g monoglyceride stearate, and carry out the compound anti-acne active substance obtained in step A. Mix, then heat to 85°C, and stir with a propeller stirrer at a speed of 600 rpm for 10 minutes to obtain a liquid oil phase;
[0036] C. Weigh 92.8g of distilled water at 75°C, mix the distilled water with the liquid oil obtained in step B to obtain a mixed solution, and stir the mixed solution evenly with a propeller stirrer at a speed of 600 rpm;
[0037] D. Pour the mixed solution obtained in step C into a high-pressure homogenizer for emulsification, control the pressure at 150 MPa, and the temperature at 75° C., and circ...
Embodiment 3
[0046] A preparation method of compound acne-removing lipid nanoparticle emulsion, comprising the steps of:
[0047] A. Take by weighing 2.5g Vitex paniculata extract, 5.0g Centella asiatica extract, 0.5g tetrahydropiperine to form a compound acne-removing active substance;
[0048] B. Weigh 1.0g poloxamer 188, 3.0g poloxamer 407, 4.0g polyglycerol-10 myristate, 16g monoglyceride stearate, and mix them with the compound acne active substance obtained in step A , then heated to 82°C, and stirred with a propeller stirrer at a speed of 600 rpm for 10 minutes to obtain a liquid oil phase;
[0049] C. Weigh 68.0 g of distilled water at 82°C, mix the distilled water with the liquid oil obtained in step B to obtain a mixed solution, and stir the mixed solution evenly with a propeller agitator at a speed of 600 rpm;
[0050] D. Pour the mixed solution obtained in step C into a high-pressure homogenizer for emulsification, control the pressure at 120 MPa, and the temperature at 85° C....
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