Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy

A technology of skeletal muscle and diaphragm, applied in the field of aromatic cationic peptide composition, which can solve the problems of incomplete defense

Inactive Publication Date: 2012-12-19
UNIV OF FLORIDA RES FOUNDATION INC +1
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, inhibition of xanthine oxidase activity does not fully protect against the effects of skeletal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy
  • Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy
  • Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0244] A. Test design

[0245] The purpose of this experiment was to demonstrate the role of mitochondrial ROS emission in MV-induced diaphragmatic weakness and to demonstrate the effect of a mitochondrial-targeted antioxidant peptide (SS-31) on mitochondrial function and rat diaphragm. Two different groups of rats (1 and 2) were treated as follows.

[0246] 1. Conscious and spontaneously breathing rats

[0247] To determine the effect of a mitochondrial-targeted antioxidant (SS-31) on diaphragmatic contractile function, fiber cross-sectional area (CSA), and mitochondrial function in conscious, spontaneously breathing rats, animals were treated as follows. Animals (n = 6 / group) were randomly assigned to one of two test groups: (1) control group - injected (intraperitoneal, i.p.) saline every 3 hours for 12 hours; and (2) Mitochondrial antioxidant group - Injection (intraperitoneal, i.p.) of SS-31 every 3 hours for 12 hours. Diaphragmatic contractile function, fibrous CSA, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide.

Description

[0001] governmental support [0002] This invention was made with Government support under Grant R01HL08783 awarded by the National Institutes of Health. The US Government has certain rights in this invention. [0003] Cross References to Related Applications [0004] This application claims priority to US Provisional Application No. 61 / 308508, filed February 26, 2010, which is incorporated herein by reference in its entirety. technical field [0005] Disclosed herein are methods and compositions comprising aromatic-cationic peptides for preventing and treating skeletal muscle weakness (eg, weakness, dysfunction, and / or muscle wasting). In particular, disclosed herein are methods and compositions for the prevention and treatment of mechanical ventilation (MV)-induced diaphragmatic weakness and disuse-induced skeletal muscle weakness. Background technique [0006] The following descriptions are provided for the reader's convenience. None of the information provided or ref...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K38/05
CPCA61K38/06A61P39/06A61P21/00
Inventor 黑兹尔·H·司徒斯科特·克莱恩·鲍尔斯
Owner UNIV OF FLORIDA RES FOUNDATION INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap