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Preparation method of Zhidai tablets

A technology of taking tablets and extracting, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, plant raw materials, etc., can solve the problems of large dosage, rough process, and many impurities for patients, and achieve the effect of reducing dosage.

Inactive Publication Date: 2012-12-26
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Zhidai Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affected the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 195g of tomb head, 195g of Sophora flavescens, 260g of golden cherry, 130g of Anemarrhena fried with salt, and 130g of fried Atractylodes, add the fried Atractylodes to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; take Mutouhui, Sophora flavescens, Fructus Rosa, and fried Anemarrhena anemarrhena, crush them, add 2L of 70% ethanol, and put them into a microwave extraction device Microwave extraction was carried out in a medium with an extraction power of 400W, and the extraction was performed twice for 4 minutes each time. The extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, and 5 times the volume of the elu...

Embodiment 2

[0026] Take 195g of tomb head, 195g of Sophora flavescens, 260g of golden cherry, 130g of Anemarrhena fried with salt, and 130g of fried Atractylodes, add the fried Atractylodes to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, supercritical extract is obtained, and it is used for later use; take Mutouhui, Sophora flavescens, Fructus Rosa, and Anemarrhena fried with salt, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device Microwave extraction was carried out in a medium with an extraction power of 600W, and the extraction was performed twice, each time for 8 minutes. The extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, and 5 times the volum...

Embodiment 3

[0029] Take 195g of tomb head, 195g of Sophora flavescens, 260g of golden cherry, 130g of Anemarrhena fried with salt, and 130g of fried Atractylodes, add the fried Atractylodes to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, and it is used for later use; take Mutouhui, Sophora flavescens, Rosa chinensis, and salt-fried Anemarrhena, pulverize, add 2L of 70% ethanol, and put it into a microwave extraction device Microwave extraction was carried out in a medium with an extraction power of 500W, and the extraction was performed twice for 6 minutes each time. The extracts were combined, concentrated, added to a D101 macroporous adsorption resin column, eluted with 50% ethanol, and 5 times the column ...

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PUM

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Abstract

The invention provides a preparation method of Zhidai tablets. The Zhidai tablets are prepared by taking 195g of diversifolious patrinia root, 195g of radix sophorae flavescentis, 260g of cherokee rose fruit, 130g of salt-fried common anemarrhena rhizome and 130g of fried atractylodes rhizome as active pharmaceutical ingredients and carrying out supercritical extraction and microwave extraction. By adopting the preparation method, the content of matrine is greatly increased.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of Zhidai tablets. Background technique [0002] Zhidai tablet is recorded in the standard WS3-B-0102-89 of the Ministry of Health. It is made of 195g tomb head, 195g flavescens, 260g golden cherry, 130g fried anemarrhena and 130g fried atractylodes as raw materials. It can clear away dampness and heat , stop belt. Betting for hot and humid, red belt, leucorrhea, yellow belt. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Zhidai Tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , Seriously affecting the clinical application of this product. Contents of the invention [0004] Purpose of the inv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61K9/20A61P15/00
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH