Antibodies binding to an intracellular PRL-1 OR PRL-3 polypeptide

A PRL-1, antibody technology, applied in the medical field, can solve the problem that the antibody cannot pass through the cell membrane and cannot approach the antigen, etc.
CN102847148AInactive Publication Date: 2013-01-02AGENCY FOR SCI TECH & RES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
AGENCY FOR SCI TECH & RES
Publication Date
2013-01-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

We provide an antibody capable of binding to an intracellular PRL-I or PRL-3 polypeptide, in which the antibody is capable of binding to an epitope bound by antibody 269, antibody 223 or antibody 318. Such anti-PRL antibodies may be capable of binding to intracellular PRL-I or PRL-3. They may be suitable for use as therapies against cancer or metastasis thereof, or in clinical diagnosis to identify PRL-3 or PRL-I positive patients.
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Description

[0001] This application is a divisional application of an invention patent application with an application date of May 3, 2008, an application number of 200880023052.3, and an invention title of "antibody that binds to intracellular PRL-1 polypeptide or PRL-3 polypeptide". technical field

[0002] The invention relates to the fields of medicine, cell biology, molecular biology and biochemistry. The invention also relates to the medical field.

[0003] In particular, the invention relates to the treatment and diagnosis of diseases, especially cancer, and compositions for such use. Background technique

[0004] Cancer is a serious health problem worldwide. In 2007, an estimated 7.6 million people worldwide died of cancer. In the UK, for example, cancer kills 126,000 people every year. One in four people die from cancer.

[0005] Known treatments for cancer include surgery, chemotherapy and radiation therapy. Many cancers can be cured if detected early enough.

[0006] 10...

Claims

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