Combinations of preservatives for ophthalmic compositions

A composition and antiseptic technology, which is applied in the direction of drug combination, animal repellent, plant growth regulator, etc., can solve the problems of reducing the concentration of preservatives and failing to pass through
CN102883708AInactive Publication Date: 2013-01-16ALLERGAN INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ALLERGAN INC
Publication Date
2013-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides a preservative composition for protecting ophthalmic solutions from microbial attack comprising a combination of benzalkonium ion and polyhexamethylene biguanide (PHMB) wherein the combined concentrations of benzalkonium ion and polyhexamethylene biguanide (PHMB) in said composition is sufficient to provide protection against microbial attack when said composition is added to an ophtalmic solution as compared to said ophthalmic soulution having the same concentration of benzalkonium ion and polyhexamethylene biguanide (PHMB), alone.
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Description

[0001] cross reference

[0002] This application claims the benefit of US Provisional Application Serial No. 61 / 321,701, filed April 7, 2010, which is hereby incorporated by reference in its entirety. technical field

[0003] The present invention relates to the field of preservatives for ophthalmic solutions, especially aqueous ophthalmic solutions, which are prone to spoilage by exposure to the environment. More particularly, the present invention relates to ophthalmic compositions, including those used for drug delivery to the eye, those used for the treatment of dry eye and for eye care, contact lens care compositions, and the like, which may benefit from preservation. Background technique

[0004] Ophthalmic compositions often utilize at least one preservative, depending on the type of composition. Certain therapeutic agents included in these compositions are often irritating to the eyes. This side effect may be reduced or eliminated in some cases if reduced concentra...

Claims

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