Dopamine prodrug composition and preparation method thereof
A dopamine and composition technology is applied in the field of pharmaceutical compositions containing dopamine prodrugs and the preparation thereof, and can solve stability problems such as complex composition components and preparation methods, the quality of finished products cannot meet quality standards, product discoloration and other stability problems masking, etc. problem, to achieve the effect of cheap and easy-to-obtain excipients, excellent stability and low cost
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Embodiment 1
[0083]
[0084] Preparation:
[0085] The hypromellose was configured as a 5% aqueous solution, and anhydrous citric acid was added and stirred until dissolved. Put levodopa, benserazide hydrochloride, and starch into a PMA-25 high-speed stirring granulator (GEA Company, Germany) after crushing and sieving, start mixing, add slurry soft materials, and pass through a YK-60 oscillating granulator (Shanghai) Tianxiang Jiantai Pharmaceutical Machinery Co., Ltd.) sieves the wet granules, then the wet granules are dried on the FL-5 type fluidized granulator (Shanghai Huafa Pharmaceutical Machinery Complete Set Development Company), granulated, and magnesium stearate is added. After mixing by a V-type high-efficiency mixer (Shanghai Tianhe Pharmaceutical Machinery Co., Ltd.), GKF-120 capsule filling machine (Bosch Packaging Technology (Hangzhou) Co., Ltd.) fills the capsules.
Embodiment 2
[0087]
[0088] Preparation:
[0089] The hypromellose was configured as a 4% aqueous solution, and anhydrous citric acid was added and stirred until dissolved. Put levodopa, benserazide hydrochloride, and starch into a PMA-25 high-speed stirring granulator (GEA Company, Germany) after crushing and sieving, start mixing, add slurry soft materials, and pass through a YK-60 oscillating granulator (Shanghai) Tianxiang Jiantai Pharmaceutical Machinery Co., Ltd.) sieves the wet granules, then the wet granules are dried on the FL-5 type fluidized granulator (Shanghai Huafa Pharmaceutical Machinery Complete Set Development Company), granulated, and magnesium stearate is added. After mixing by a V-type high-efficiency mixer (Shanghai Tianhe Pharmaceutical Machinery Co., Ltd.), GKF-120 capsule filling machine (Bosch Packaging Technology (Hangzhou) Co., Ltd.) fills the capsules.
Embodiment 3
[0091]
[0092]
[0093] Preparation:
[0094] The hypromellose was configured as a 3% aqueous solution, and anhydrous citric acid was added and stirred until dissolved. Put levodopa, benserazide hydrochloride, and starch into a PMA-25 high-speed stirring granulator (GEA Company, Germany) after crushing and sieving, start mixing, add slurry soft materials, and pass through a YK-60 oscillating granulator (Shanghai) Tianxiang Jiantai Pharmaceutical Machinery Co., Ltd.) sieves wet granules, and then dries the wet granules in a DHG-9246A electric heating constant temperature blast drying oven (Shanghai Jinghong Experimental Equipment Co., Ltd.), granulates, and adds stearic acid Magnesium, after mixing by a V-type high-efficiency mixer (Shanghai Tianhe Pharmaceutical Machinery Co., Ltd.), GKF-120 capsule filling machine (Bosch Packaging Technology (Hangzhou) Co., Ltd.) to fill the capsules.
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Abstract
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