Novel noninvasive measuring method for left ventricular end diastolic pressure

Abstract

The invention provides a novel noninvasive measuring method for a left ventricular end diastolic pressure, which belongs to the field of medical cardiovascular systems and can be applied to fundamental research of the field and clinical diagnosis and treatment of related diseases. At prevent, a noninvasive left ventricular end diastolic pressure measuring method is lacked in clinics and screening and accurate diagnosis of patients with suspicious and asymptomatic left ventricular end diastolic dysfunctions are restricted. The invention provides a method capable of non-invasively, accurately, simply and conveniently measuring the left ventricular end diastolic pressure; on the basis of the human body hemodynamic principle and the relation between pressure in each chamber of the heart and pressure in the lung, a pulmonary valve is open in diastole in advance by means of intrapulmonic pressure variation caused by Muller action; transpulmonary valvular pressure at the moment is non-invasively measured through a self-made face mask and an ultrasonic cardiograph; and right ventricular diastolic pressure can be non-invasively measured, so that the left ventricular end diastolic pressure is obtained.

Description

Technical field [0001] The patent of the present invention relates to a new method for non-invasive measurement of left ventricular end diastolic pressure, and the non-invasive measurement of left ventricular end diastolic pressure can be realized by using the patent of the present invention. This patent is a new invention in the field of medical cardiovascular system, which can be applied to basic research in this field and clinical diagnosis and treatment of related diseases. Background technique [0002] Left ventricular diastolic dysfunction is the most common and earliest abnormal cardiac function, which can be an independent cause of death. It is of great significance to improve the prognosis if the diagnosis can be made before the patient has symptoms. The American College of Cardiology Guidelines for the Diagnosis and Treatment of Chronic Heart Failure (ACC / AHA Practice Guidelines) point out that the early detection of asymptomatic left ventricular diastolic dysfunction ...

AI Technical Summary

Problems solved by technology

At present, most of the left ventricular end-diastolic pressure is measured clinically through invasive cardiac catheterization. This method is expensive, has many complications, and is invasive, and its clinical application is also greatly limited.

In addition, according to the ultrasonic Doppler pulmonary regurgitation velocity, the method of calculating the transpulmonary valve pressure by simplifying the Bernoulli equation and adding the right atrial diastolic pressure to roughly calculate the left ventricular diastolic pressure also has great limitations. Depends on the presence of pulmonary regurgitation, clinically about 1 / 4 to 1 / 5 of the patients do not have pulmonary regurgitation, and the calculated value is only an approximation

However, there is currently a lack of non-invasive, accurate, and simple methods for measuring left ventricular end-diastolic pressure clinically, which limits the screening and accurate diagnosis of patients with suspected and asymptomatic left ventricular diastolic dysfunction

The accuracy and specificity of the existing evaluation methods for left ventricular end-diastolic pressure are not ideal, and there is an urgent need for a non-invasive, accurate and simple method for measuring left ventricular end-diastolic pressure in clinic