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Noninvasive method for determining iron content in brain tissue

A technology of iron content and brain tissue, applied in the directions of diagnostic recording/measurement, medical science, diagnosis, etc., can solve the problems of inaccurate measurement of brain regions and the influence of different parameters, and achieve the effect of simple operation process

Inactive Publication Date: 2012-10-24
ZHEJIANG UNIV
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Problems solved by technology

[0003] In order to overcome the limitations of some specific brain regions that exist in the existing measurement of brain iron content indicators, such as inaccurate measurement, being affected by different parameters, and requiring specific workstations, the purpose of the present invention is to provide a method for non-invasive measurement of brain tissue iron content

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  • Noninvasive method for determining iron content in brain tissue
  • Noninvasive method for determining iron content in brain tissue

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Embodiment

[0030] 1) Recruit 30 cases of healthy people aged 30-100 and sign the informed consent.

[0031] 2) A magnetic resonance instrument (Signa Excite HD, General Electric Medical System, Milwaukee, USA) produced by GE with a magnetic field strength of 3.0 Tesla was used to collect T2*-weighted three-dimensional gradient echoes from the whole brain of the participants. wave sequence (Enhanced gradient echo T2* weighted angiography, ESWAN), and save the magnitude images (magnitude images) in the resulting image data. The set parameters are as follows: using three-dimensional multi-echo gradient echo, a total of 11 equal time interval echoes: the first echo time = 4.5 milliseconds, echo interval time = 4.5 milliseconds, repetition time = 58 milliseconds, deflection Angle = 20°, matrix = 256 × 256, field of view = 240 × 240 mm2, layer thickness = 2.0 mm, layer spacing = 0 mm, resolution = 0.4688 × 0.4688 mm / pixel.

[0032] 3) Measure the signal intensity of caudate nucleus 1, putamen...

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Abstract

The invention discloses a noninvasive method for determining iron content in brain tissue. The method comprises the steps of performing whole brain magnetic susceptibility imaging on participator with magnetic resonance instrument, and storing amplitude image in obtained image data; measuring average signal intensities of caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra, frontal lobe white matter and medulla oblongata in brain region of each participator, and dividing with the average signal intensity of medulla oblongata as internal reference respectively, to obtain relative amplitude signal intensity data; performing normal distribution conversion on the obtained relative amplitude signal intensity data, performing Pearson linear correlation analysis with brain region iron content distribution data of population of same age group published by autopsy research, and fitting to obtain a simple relation equation according to correlation analysis result. The method can non-invasively accurately estimate iron content in brain, only needs measurement and calculation on a simple third-party image processing software during measurement, and needs no special workstation.

Description

technical field [0001] The present invention relates to a method for the non-invasive measurement of brain iron content in medical neuroimaging. Background technique [0002] Iron deposition in the brain is related to some neurodegenerative diseases. With the development of medical imaging, many magnetic resonance parameter values ​​are used to evaluate the iron content of brain tissue. The more recognized ones include: phase value, effective lateral Relaxation rate (R2*), quantitative susceptibility (quantitative susceptibility), etc. However, these parameters have certain defects in the reflection of iron content: for example, because of the directionality of phase information, the iron content in certain specific brain regions (such as globus pallidum) is inaccurate; R2* also includes Magnetic field and brain tissue information, different tissue components have a certain influence on its value; at the same time, various magnetic resonance parameters, such as echo time (e...

Claims

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Application Information

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IPC IPC(8): A61B5/055
Inventor 严慎强楼敏孙建忠
Owner ZHEJIANG UNIV
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