A kind of synthesis and separation and purification method of high molecular polymer
A high molecular polymer, separation and purification technology, applied in the field of synthesis and separation and purification of sevelamer carbonate, can solve the problems of difficult separation and purification, high molecular polymer swelling with water, etc.
Active Publication Date: 2016-06-29
CP PHARMA QINGDAO CO LTD
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Problems solved by technology
[0005] The purpose of the present invention is to overcome the problem that high molecular polymers swell with water and difficult to separate and purify during the synthesis process of sevelamer carbonate. The present invention provides a method for the synthesis, separation and purification of high molecular polymers, which is simple and easy to implement , fast, efficient, energy-saving, suitable for large-scale industrial production
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[0011] The present invention will be described in further detail below in conjunction with the examples.
[0012] The process route is as follows:
[0013]
[0014] Steps:
[0015] Add a certain volume of "allylamine hydrochloride" (SV-0) into the reaction kettle, stir, and heat under nitrogen protection, add 2,2-azobis(2-methylpropylimidium ) dihydrochloride, keep the reaction system at 50°C-60°C, stir the reaction, stop heating, naturally cool down to room temperature, remove the nitrogen, add purified water, then add to the methanol solution, maintain the stirring speed at 100rpm, stir, and centrifuge , suction filtration, to obtain granular solids, dry to obtain white solids (SV-1); add SV-1 to the reaction kettle, add purified water, keep warm, stir, after completely dissolving, add alkaline substances to adjust the pH to 10 , then add epichlorohydrin, stir slowly, keep warm and react until it is jelly-like, solidify, then add it into methanol solution, keep the stir...
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The invention relates to a high-molecular polymer synthesis and separation and purification method, in particular to sevelamer carbonate synthesis and separation and purification, which belongs to the technical field of medicine synthesis and organic compound synthesis and preparation. The invention aims to provide a novel high-molecular polymer synthesis and separation and purification method with rapidity, high efficiency and energy saving to overcome the defects of the existing synthesis and separation and purification technology. According to the method, osmotic pressure difference of an organic solvent and water and influence of acid and base on a hydrate are utilized to creatively solve the problem that a high-molecular polymer swells in water and is difficult to separate and purify in the process of synthesis. The method has the advantages of rapidity, high efficiency, energy saving, simplicity and easiness in implementation, the reaction period is shortened, and the method is suitable for industrial production.
Description
technical field [0001] The invention belongs to the technical field of medicine synthesis and organic compound synthesis preparation. It is a method for the synthesis, separation and purification of high molecular polymers, and particularly relates to the synthesis, separation and purification of sevelamer carbonate. Background technique [0002] Sevelamer carbonate is a non-absorbable phosphorus-binding, cross-linked polymer that is free of metals and calcium. Sevelamer carbonate can reduce the concentration of phosphorus in serum by combining with phosphorus in the gastrointestinal tract and reducing the absorption of phosphorus. It is suitable for controlling serum phosphorus levels in patients with chronic kidney disease (CKD) on dialysis. At present, it is the drug of choice for reducing blood phosphorus clinically in Europe and the United States. [0003] The synthesis, separation and purification of Sevelamer Carbonate have been reported in several literatures (Pro...
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IPC IPC(8): C08F126/02C08F8/44C08J3/24C08J3/00A61P3/12
Inventor 王明刚任莉陈阳生孙桂玉翟翠云刘晓霞
Owner CP PHARMA QINGDAO CO LTD