Preparation method and application of antiphlogosis tablet

A technology of extracting and wild chrysanthemum, applied in the direction of medical preparations containing active ingredients, anti-inflammatory agents, pharmaceutical formulas, etc., can solve the problems of many impurities, backwardness, and impact on clinical application

Active Publication Date: 2013-03-27
房新冰
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of anti-inflammatory tablets, but the method of powdering and de...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and application of antiphlogosis tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Get 446g of dandelion, 446g of Viola chinensis, 446g of wild chrysanthemum, and 446g of Scutellaria baicalensis, add wild chrysanthemum into CO2 supercritical extractor, ethanol is used as entrainer, and the volume percentage of entrainer accounting for the total extraction solvent is 4%, and the extraction pressure is 15MPa , temperature 30°C, CO2 flow rate 1m1 / g crude drug·min, extraction time 150min, supercritical extract was obtained, and set aside; the rest of the traditional Chinese medicine was taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, extraction power 400W, extract 2 times, 4 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and Dry to obtain the microwave extract and set aside; mix the above supercritical extract and microwave ...

Embodiment 2

[0028] Take dandelion 446g, viola 446g, wild chrysanthemum 446g, and scutellaria baicalensis 446g, add wild chrysanthemum to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , set aside; mix the above supercritical extract...

Embodiment 3

[0031] Take dandelion 446g, viola 446g, wild chrysanthemum 446g, and scutellaria baicalensis 446g, add wild chrysanthemum to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , set aside; mix the above supercriti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a preparation method of an antiphlogosis tablet which is prepared from crude drugs including 446g of dandelion, 446g of herba violae, 446g of wild chrysanthemum and 446g of radix scutellariae through supercritical extraction and microwave extraction, so that the content of baicalein is greatly improved. The invention also provides the application of the antiphlogosis tablet in preparing a medicine for restraining proliferation of human acute promyelocytic leukemia cell, NB4 cell.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of anti-inflammatory tablets. Background technique [0002] Anti-inflammatory tablets are recorded in the standard WS3-B-0809-91 of the Ministry of Health. It is made of 446g of dandelion, 446g of Viola chinensis, 446g of wild chrysanthemum, and 446g of Scutellaria baicalensis as raw materials. For respiratory tract infection, fever, pneumonia, bronchitis, cough with phlegm, boils, etc. [0003] In the prior art, there is no report about the use of supercritical and microwave technology in the extraction and preparation of anti-inflammatory tablets. However, the method of powdering and boiling in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. Seriously affected the clinical application of this product. Contents of the inv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/86A61K9/20A61P29/00A61P31/04A61P35/02
Inventor 不公告发明人
Owner 房新冰
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap