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A kind of traditional Chinese medicine composition for treating chronic prostatitis

A technology for chronic prostatitis and composition, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve problems such as the effect is not as good as in vitro test, question of microbial pathogenicity, difficult for drugs to pass through the blood-prostate barrier, etc., and achieve a good society. Beneficial, low cost, and the effect of promoting long-term application

Active Publication Date: 2015-12-02
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect of anti-infective drug treatment is far less than in vitro tests, on the one hand, it is difficult for drugs to pass through the blood-prostate barrier; on the other hand, the pathogenicity of many microorganisms is still questioned

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh raw materials: cooked aconite 12g, gentian 9g, lychee core 6g, tangerine plum 6g, green peel 6g, mountain gardenia 6g, flavescens 6g.

[0017] Decocting and extracting the above-mentioned crude drug twice with water, the amount of water added for the first extraction is 15 times of the amount of medicine, and the extraction time is 3 hours; the amount of water added for the second extraction is 10 times of the amount of medicine, and the extraction time is 3 hours; Add ethanol for alcohol precipitation, adjust the alcohol content to 30%, filter, and concentrate the alcohol precipitation solution; use vacuum drying to dry, and the vacuum drying temperature is controlled at 50°C; after drying, the water content of the medicinal extract is controlled below 5%; Add an appropriate amount of auxiliary materials micropowder silica gel, dextrin, and starch; mix the above materials, adopt wet granulation, dry, fill the granules after granulation, and pack them into bags, ea...

Embodiment 2

[0019] Weigh raw materials: cooked aconite 15g, gentian 3g, lychee core 5g, citrus plum 3g, green skin 3g, mountain gardenia 6g, flavescens 4.5g.

[0020]Decoction and extraction of the above-mentioned crude drug twice with water, the first time the amount of water added is 10 times the amount of medicine, and the extraction time is 2 hours; the second time the amount of water added is 7 times the amount of medicine, and the extraction time is 2 hours; filter, Combine the filtrates and concentrate; use vacuum drying to dry, and the vacuum drying temperature is controlled at 70°C; the moisture content of the medicinal extract after drying is controlled below 5%; add appropriate amount of auxiliary materials micropowder silica gel, starch, and microcrystalline cellulose to the medicinal extract; The above materials are mixed, granulated by wet method, dried, pressed into tablets after granulation, and made into tablets, each tablet is 0.5 g.

Embodiment 3

[0022] Weigh raw materials: cooked aconite 3.0g, gentian 6.0g, litchi core 5g, citrus plum 3.0g, green bark 3.0g, Shanzhi 6.0g, flavescens 4.5g.

[0023] Decocting and extracting the above-mentioned crude drug twice with water, the amount of water added for the first extraction is 6 times of the amount of medicine, and the extraction time is 0.5 hour; the amount of water added for the second extraction is 4 times of the amount of medicine, and the extraction time is 0.5 hour; Filtrate, combine the filtrates, and concentrate; use spray drying to dry, and spray drying is to concentrate the medicinal solution to 1.1g / ml (60°C thermal measurement), the inlet air temperature is controlled at 150°C, and the outlet air temperature is controlled at 80°C; After drying, the water content of the medicinal extract is controlled below 5%; add appropriate amount of auxiliary materials micro-powdered silica gel and dextrin to the medicinal extract; mix the above materials, use wet granulation...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic prostatitis. The traditional Chinese medicine composition comprises water extract or water-extraction alcohol-precipitation extract of 5.26 to 37.97wt% of prepared monkshood, 4.54 to 19.67wt% of gentiana scabra bunge, 7.81 to 30.77wt% of lychee seed, 4.76 to 26.86wt% of trifoliate orange, 4.84 to 28.99wt% of pericarpium citri reticulatae viride, 9.23 to 31.75wt% of cape jasmine fruit and 6.98 to 28.12wt% of lightyellow sophora root. The extract obtained by water-extraction or water-extraction alcohol-precipitation is prepared into the traditional Chinese medicine composition for oral administration. The traditional Chinese medicine composition can effectively treat chronic prostatitis and has an important meaning for satisfying medical clinical demands and market demands.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating chronic prostatitis. Background technique [0002] Chronic prostatitis is a clinical syndrome mainly manifested by lower urinary tract symptoms and pain in the genital area of ​​the bladder. , CPS). Chronic prostatitis (CP) is a common disease in adult males, with an estimated prevalence of 9% to 14% among males worldwide. In our country, its pathological incidence rate is 24.3%. It is estimated that 50% of men may have had symptoms of prostatitis in their lifetime. Due to the lack of in-depth understanding of the etiology and pathogenesis of CP, the effect of treatment is not satisfactory. In 1995, the National Institutes of Health (NIH) of the United States proposed to divide prostatitis into: type I is acute bacterial prostatitis; type II is chronic bacterial prostatitis; type III is chronic nonbacterial p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/77A61P13/08
Inventor 彭煜彭培初汤秀珍樊敏伟杜晨捷胡蓉婉瞿敏明
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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